Ethnicity and Nativity in Cancer - Latino & Asian Enclaves: The ENCLAVE Study

癌症中的种族和出生地 - 拉丁裔

基本信息

批准号：
9885937
负责人：
Sandi Leigh Pruitt
金额：
$ 62.92万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9885937
关键词：
Address Adopted American Asian Americans Asians Attention Automobile Driving Breast Businesses California Cancer Center Cancer Control Cause of Death Cervix Uteri Chinese People Collaborations Colorectal Colorectal Cancer Communities Community Outreach Country Cuban Data Development Diagnosis Early Diagnosis Ensure Environment Ethnic Origin Ethnic group Filipino Florida Funding Future Geography Health Health Promotion Healthcare Heterogeneity Immigrant Immigration Incidence Individual Infrastructure Intervention Japanese Population Joints Koreans Latina Latino Leadership Linguistics Link Literature Malignant Neoplasms Malignant neoplasm of cervix uteri Measures Methodology Methods Mexican NCI-Designated Cancer Center Neighborhoods New Jersey New York Outcome Patients Pattern Population Population Growth Procedures Puerto Rican Race Research Personnel Resources Role Science South Asian Stage at Diagnosis Subgroup Texas Time cancer health disparity cancer prevention cancer site cancer type data registry design disadvantaged population disparity reduction ethnic minority population evidence base experience health disparity improved improved outcome indexing malignant breast neoplasm mortality multilevel analysis neighborhood disadvantage neoplasm registry novel population based programs racial and ethnic residence resilience response social social capital socioeconomic disadvantage stressor surveillance data

项目摘要

Project Summary/Abstract Cancer is the leading cause of death for Latinos and Asian Americans, who are among the fastest growing populations in the U.S. A large proportion of Latinos and Asian Americans live in ethnic enclaves—distinct neighborhoods with high concentrations of individuals of the same ethnic origin (“co-ethnic residents”) that are also characterized by recent immigration and linguistic isolation. The existing literature is mixed, with some studies showing that ethnic enclave residence (vs. non-enclave residence) and foreign- (vs. U.S.-) birthplace are associated with both better and/or worse outcomes across the cancer continuum. In this study, we will pool cancer registry data across five states (CA, FL, NJ, NY, TX) comprising the majority of Latinos and Asian Americans in the U.S. and link these data to contextual data characterizing the social, built and healthcare environments. We will determine whether and how ethnic enclave residence and foreign-birthplace are associated with three cancer outcomes (incidence, stage at diagnosis, survival) experienced by nine of the largest Latino and Asian ethnic groups (Cuban, Mexican, Puerto Rican, Chinese, Filipino, Japanese, Korean, South Asian, Vietnamese) diagnosed with three cancer types (breast, cervical, and colorectal cancers). Specifically, we aim to define and characterize ethnic enclaves, and examine cancer incidence by enclave residence (Aim 1) and determine independent and joint associations of ethnic enclave residence and nativity (foreign vs. US birthplace) on stage at diagnosis (Aim 2) as well as on mortality (Aim 3). With over 200,000 Latino and Asian American breast, colorectal, and cervical cancer cases, we will use multilevel models to understand the impact of ethnic enclaves on cancer outcomes for these understudied populations. In doing so, our study will accelerate discovery about the intersections between neighborhoods, ethnicity, nativity, and cancer and will improve data and methods used by central cancer registries across the U.S. Findings have potential to inform development of multilevel interventions to leverage enclave attributes that promote health and to address any barriers to reduce disparities and improve outcomes for our fastest growing ethnic minority and immigrant communities. We will disseminate our enclave measure and imputation procedures for missing data to the North American Association of Central Cancer Registries (NAACCR). In doing so, our methods will improve completeness of cancer registry data for surveillance of the growing Latino and Asian American populations. Our dissemination plan with collaboration from NAACCR leadership as well as the Offices of Community Outreach and Engagement at NCI Designated Cancer Centers in five states will ensure 1) methods are readily adopted by cancer registries and health disparities researchers across the nation; and 2) findings inform community-engaged efforts to address multilevel cancer disparities among Latino and Asian populations.

项目概要/摘要癌症是拉丁裔和亚裔美国人死亡的主要原因，他们是增长最快的人群之一美国人口中很大一部分拉丁裔和亚裔美国人生活在不同的种族飞地具有相同种族血统的个人（“同族居民”）高度集中的社区另一个特点是最近的移民和语言隔离。现有的文献是混合的，有一些。研究表明，种族飞地居住地（与非飞地居住地相比）和外国出生地（与美国出生地相比）与整个癌症连续体的更好和/或更差的结果相关。在这项研究中，我们将汇集。五个州（加利福尼亚州、佛罗里达州、新泽西州、纽约州、德克萨斯州）的癌症登记数据，其中大多数为拉丁裔和亚裔居住在美国的美国人将这些数据与描述社会、建筑和医疗保健的背景数据联系起来我们将确定民族飞地居住地和外国出生地是否以及如何。与九名患者所经历的三种癌症结果（发病率、诊断分期、生存率）相关最大的拉丁美洲和亚洲民族（古巴人、墨西哥人、波多黎各人、中国人、菲律宾人、日本人、韩国人、南亚裔、越南裔）被诊断患有三种癌症（乳腺癌、宫颈癌和结直肠癌）。具体来说，我们的目标是定义和表征种族飞地，并按飞地检查癌症发病率居住地（目标 1）并确定民族飞地居住地和出生地的独立和联合关联（外国与美国出生地）在诊断阶段（目标 2）以及死亡率（目标 3）超过 200,000 人。对于拉丁美洲和亚裔美国人的乳腺癌、结直肠癌和宫颈癌病例，我们将使用多级模型来了解种族聚居地对这些未被充分研究的人群的癌症结果的影响。我们的研究将加速发现社区、种族、出生地和文化之间的交叉点癌症并将改进美国各地中央癌症登记处使用的数据和方法为多层次干预措施的发展提供信息的潜力，以利用飞地属性促进健康并解决任何障碍，以减少差距并改善我们增长最快的少数民族的成果我们将传播我们的飞地措施和失踪人员估算程序。在此过程中，我们的方法将向北美中央癌症登记协会 (NAACCR) 提供数据。提高癌症登记数据的完整性，以监测不断增长的拉丁裔和亚裔美国人我们的传播计划与 NAACCR 领导层以及以下办公室合作。五个州 NCI 指定癌症中心的社区外展和参与将确保 1) 全国各地的癌症登记处和健康差异研究人员很容易采用这些方法；2) 研究结果为社区参与解决拉丁裔和亚裔之间多层次癌症差异的努力提供了信息人口。