ACTIVE Cognitive Training Trial: 20-Yr Follow-up of Functioning, Health, & Dementia

主动认知训练试验：20 年功能、健康、

基本信息

批准号：
9754732
负责人：
GEORGE W. REBOK
金额：
$ 73.81万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9754732
关键词：
Accounting Acute Address Affect Age Age of Onset Aging Algorithms Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Ambulatory Care Automobile Driving Caring Cause of Death Cessation of life Code Cognition Comorbidity Data Data Set Dementia Disease Drug Prescriptions Elderly Event Financial Hardship Financial cost Follow-Up Studies Growth Health Health Care Costs Health Care Visit Health care facility Healthcare Home Care Services Hospitalization Impaired cognition Incidence Independent Living Individual Intervention Life Link Maintenance Medicaid Medicaid eligibility Medicare claim Medicare/Medicaid Memory Mental Depression Methods Morbidity - disease rate Outcome Participant Personal Satisfaction Population Prevention Preventive care Primary Health Care Public Health Public Policy Randomized Clinical Trials Records Reporting Resources Sampling Speed Testing Training Visit base cognitive ability cognitive benefits cognitive training combat cost daily functioning depressive symptoms disability disability burden evidence base falls follow-up frailty functional loss health care service utilization health service use improved indexing innovation instrumental activity of daily living medical supply mortality novel nursing home length of stay physical conditioning prevent processing speed randomized trial therapy design treatment effect treatment group

项目摘要

Abstract The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study is the largest randomized clinical trial (N = 2802) to examine whether cognitive training enhanced both cognitive abilities and everyday functioning in normal older adults. Subjects trained on memory, reasoning, or processing speed performed significantly above controls at 5- and 10-year follow-ups. In addition, trained subjects reported less difficulty in performing IADL tasks at 10-year follow-up. Speed and reasoning training was associated with reduction in auto crashes and in driving cessation. Recent preliminary, but promising findings suggest an effect of training on incidence of Alzheimer's and related dementias. While these findings provide strong support for the benefits of cognitive training, the results focus on only short-term outcomes. This proposed 20-year follow-up would allow us to address questions highly relevant to health care and public policy that can only be addressed when the majority of the sample is deceased: Is training-related enhancement of cognition and everyday functioning associated with a long-term reduction in disability, loss of independence, and incident dementia in advanced old age and a reduction in associated financial costs? We propose to employ a wide range of linked data including: Medicare and Medicaid Claims, National Death Index, driving records, and credit reports. This study will assess the long-term impact and sustainability of the ACTIVE interventions on critical real life outcomes and related costs in advanced old age, including 1) Maintenance of independent functioning; 2) Physical health, disability, frailty, and mortality; 3) Incidence and duration of Alzheimer's and related dementias and depression.

抽象的针对独立和活力老年人的高级认知训练 (ACTIVE) 研究是规模最大的随机研究临床试验（N = 2802）检验认知训练是否增强认知能力和日常能力正常老年人的功能。受过记忆、推理或处理速度训练的受试者 5 年和 10 年随访时显着高于对照。此外，受过训练的受试者报告说， 10 年随访时执行 IADL 任务。速度和推理训练与减少汽车碰撞和停车。最近初步但有希望的发现表明培训的效果阿尔茨海默病和相关痴呆症的发病率。虽然这些发现为这些好处提供了强有力的支持认知训练的结果只关注短期结果。这项拟议的 20 年后续行动将让我们能够解决与医疗保健和公共政策高度相关的问题，这些问题只有在以下情况下才能解决：大多数样本已去世：与训练相关的认知和日常功能是否得到增强与长期减少残疾、丧失独立性和晚期痴呆症有关老年和相关财务成本的减少？我们建议使用广泛的链接数据包括：医疗保险和医疗补助索赔、国家死亡指数、驾驶记录和信用报告。这项研究将评估积极干预措施对现实生活中关键结果的长期影响和可持续性高龄的相关费用，包括 1) 维持独立功能； 2) 身体方面健康、残疾、虚弱和死亡； 3) 阿尔茨海默病和相关痴呆症的发病率和持续时间以及沮丧。