2019 Cancer Genetics and Epigenetics GRC/GRS

2019年癌症遗传学和表观遗传学GRC/GRS

• 批准号: 9754282
• 负责人: Jonathan D. Licht
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754282
• 关键词: Biological Assay; CRISPR screen; Cancer Control; Chromatin; Chromatin Structure; Collaborations; Complement; Computer Analysis; Data; Epigenetic Process; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Genetic Heterogeneity; Genome; Goals; Inter-tumoral heterogeneity; Knowledge; Lead; Malignant Neoplasms; Modernization; Molecular; Mutation; Pathway interactions; Play; Predisposition; RNA; Research; Research Personnel; Role; Scientist; Surveys; Systems Analysis; Tail; Tumor Biology; Untranslated RNA; Work; actionable mutation; cancer diagnosis; cancer genetics; cancer genome; cancer heterogeneity; cancer therapy; epigenome; experimental study; genome-wide; inhibitor/antagonist; meetings; posters; single cell technology; symposium; targeted treatment; tumor

Summary The 2019 Conference on Cancer Genetics and Epigenetics will focus on newly emerging aspects of the field including the genetic heterogeneity of cancer, the “long tail” of less frequent cancer mutations and the importance of intertumoral heterogeneity as assayed by single cell technologies. The importance of the non-coding genome in cancer will be highlighted as well as the rapidly evolving field of RNA epigenetics. Sessions on the lessons learned from genome wide surveys of cancer susceptibility as assayed by CRISPR screens and descriptions of cancer epigenomes will be complemented by talks on basic mechanism of gene regulation relevant to cancer and how genetically and epigenetically targeted therapies can be applied to specific tumor types. It has become increasingly apparent that the organization of the genome across temporal and spatial domains plays a large role in the control of cancer gene expression patterns and tumor biology and a session on the “4-D Nucleome” and cancer is planned. The large amounts of data generated by modern cancer genetic and epigenetic experiments require new modes of computational and systems analysis which will be discussed in sessions. This meeting should appeal to a wide range of cancer researchers and molecular biologists seeking to apply their work to cancer. In addition to an outstanding set of invited speakers there will be several interactive poster sessions, one-minute "poster preview" talks and several talks selected for platform presentation from the submitted abstracts.

概括 2019年癌症遗传学和表观遗传学会议将重点关注新兴方面 该领域的重点包括癌症的遗传异质性、不太常见的癌症的“长尾” 突变和单细胞检测肿瘤间异质性的重要性 非编码基因组在癌症中的重要性也将得到强调。 快速发展的 RNA 表观遗传学领域的会议，讨论从全基因组中吸取的教训。 通过 CRISPR 筛选和癌症描述进行的癌症易感性调查 表观基因组将通过有关基因调控基本机制的讨论来补充 癌症以及如何将遗传和表观遗传靶向治疗应用于特定肿瘤 跨时间的基因组组织已经变得越来越明显。 空间域在癌症基因表达模式和肿瘤的控制中发挥着重要作用 计划举办生物学和“4-D 核组”与癌症的会议。 现代癌症遗传学和表观遗传学实验产生的结果需要新的模式 本次会议将讨论计算和系统分析。 吸引广泛的癌症研究人员和分子生物学家寻求应用他们的工作 除了一组杰出的受邀演讲者外，还将有几位互动嘉宾。 海报会议、一分钟“海报预览”演讲以及精选平台演讲 提交的摘要的演示。