Supplement to Biobehavioral Reward Responses Associated with Consumption of Nutritionally Diverse Ultra-Processed Foods

补充与食用营养多样化的超加工食品相关的生物行为奖励反应

• 批准号: 10764460
• 负责人: Erica M LaFata
• 金额: $ 7.56万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764460
• 关键词: Address; Appointment; Area; Behavioral; Biological; Biological Markers; Brain; Carbohydrates; Characteristics; Clinical; Consumption; Development; Eating; Eating Behavior; Eating Disorders; Environment; Fatty acid glycerol esters; Food; Foundations; Goals; Hyperphagia; Individual Differences; Intervention; Knowledge; Life Style; Mentored Patient-Oriented Research Career Development Award; Mentorship; Metabolic; Methodology; Methods; Nature; Nutritional; Obesity; Parents; Participant; Physiological; Predisposition; Process; Psychologist; Research; Rewards; Science; Supervision; Training; Training Activity; Universities; Weight; Weight maintenance regimen; Work; addiction; behavioral phenotyping; behavioral response; biobehavior; career; design; experience; food consumption; food environment; high reward; indexing; meetings; novel; professor; programs; psychologic; response; skills; sugar; symposium

PROJECT SUMMARY/ABSTRACT OF THE PARENT K23 AWARD My career goal is to develop an independent research program that utilizes a comprehensive, multi-method approach to investigate mechanisms by which ultra-processed foods (UPFs) directly contribute to overeating and obesity. My training as a clinical psychologist has provided me with a strong foundation in understanding behavioral responses that may contribute to overeating and individual differences in problematic eating behavior. However, I have had no formal training in biological underpinnings that may drive UPF consumption and am seeking advanced training in evaluating reward processes and identifying behavioral phenotypes within obesity. My training plan will build upon my skillsets and expand my knowledge in three areas: 1) adapting methods used to identify the reinforcing ingredients of rewarding substances to assess which attributes of UPFs contribute to their high reward potential; 2) investigating biological markers of individual differences in food reward and physiological and metabolic responses to UPF consumption; and 3) identifying behavioral phenotypes within obesity in order to better understand differential susceptibility to UPF reward. In order to achieve these objectives, I will engage in a variety of training activities, guided by my mentorship team, including regular supervision meetings, directed readings, attendance at classes, seminars, and scientific conferences, and in-lab methodological training. The proposed study will use a within-subjects design to address these training goals by evaluating differences in biobehavioral reward responses to UPFs high in both fat + refined carbohydrates, compared to UPFs high in fat only or refined carbohydrates only or minimally processed foods. Participants will each attend four food consumption appointments, one for each aforementioned food type, where subjective indices of reward and metabolic responses will be assessed while anticipating and eating the food. The present work is the first to elucidate the biological and behavioral experiences of consuming nutritionally diverse UPFs that may mechanistically contribute to overeating. Understanding which ingredients in UPFs are most reinforcing and the biobehavioral underpinnings will inform novel intervention targets for weight management and problematic eating behavior. The environment at the Center for Weight, Eating, and Lifestyle Science and state-of-the-art coursework and seminars at Drexel University are ideal for my training goals. My mentorship team will be led by Dr. Evan Forman (Professor, Department of Psychological and Brain Sciences; Director, Center for Weight, Eating, and Lifestyle Science) and includes training from Dr. Kelly Allison (Professor, Weight and Eating Disorders) in the biological underpinnings of food reward and Dr. Janet Audrain-McGovern (Professor, Addictions) in methodology used to assess the reinforcing nature of substances. This interdisciplinary team will facilitate successful implementation of the proposed research and training plan and the development of an R01 application based on the findings from the present work.

项目摘要/父级 K23 奖项摘要 我的职业目标是开发一个独立的研究项目，利用全面的、多种方法 研究超加工食品（UPF）直接导致暴饮暴食的机制的方法 和肥胖。我作为临床心理学家的培训为我的理解打下了坚实的基础 可能导致暴饮暴食的行为反应以及问题饮食的个体差异 行为。然而，我没有接受过可能推动 UPF 消费的生物基础方面的正式培训 正在寻求评估奖励过程和识别行为表型的高级培训 肥胖内。我的培训计划将建立在我的技能基础上并扩展我在三个领域的知识：1) 调整用于识别奖励物质的增强成分的方法，以评估哪些 UPF 的属性有助于其高回报潜力； 2）调查个体的生物标志物 食物奖励以及对 UPF 消耗的生理和代谢反应的差异； 3) 识别 肥胖内的行为表型，以便更好地了解对 UPF 奖励的不同易感性。在 为了实现这些目标，我将在我的导师的指导下从事各种培训活动 团队，包括定期监督会议、定向阅读、参加课程、研讨会和 科学会议和实验室方法培训。拟议的研究将采用受试者内设计 通过评估对高 UPF 的生物行为奖励反应的差异来实现这些培训目标 脂肪 + 精制碳水化合物，相比之下，UPF 仅富含脂肪或仅含精制碳水化合物或很少 加工食品。参与者每人将参加四次食品消费预约，每人一次 上述食物类型，将评估奖励和代谢反应的主观指数，同时 期待并吃食物。目前的工作是第一个阐明生物学和行为学的工作 食用营养丰富的 UPF 的经历可能会导致暴饮暴食。 了解 UPF 中的哪些成分最具强化作用以及生物行为基础将提供信息 体重管理和有问题的饮食行为的新干预目标。现场环境 德雷塞尔大学的体重、饮食和生活方式科学中心以及最先进的课程和研讨会 大学对于我的训练目标来说是理想的选择。我的导师团队将由 Evan Forman 博士（教授， 心理与脑科学系；体重、饮食和生活方式科学中心主任） 并包括凯利·艾利森博士（体重和饮食失调教授）在生物方面的培训 食物奖励的基础以及 Janet Audrain-McGovern 博士（成瘾教授）的方法论 评估物质的增强性质。这个跨学科团队将促进成功实施 拟议的研究和培训计划以及基于研究结果开发 R01 应用程序 从现在的工作来看。