Comp A: Texas BD-STEPS III Core

比较 A：Texas BD-STEPS III 核心

• 批准号: 10765401
• 负责人: A.J. Agopian
• 金额: $ 60万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10765401
• 关键词: Comp; Texas; BD; STEPS; III

PROJECT SUMMARY Birth defects are a major contributor to infant mortality, morbidity, and healthcare costs in the U.S., but the etiologies of these conditions remain unknown for most individuals, which has hindered development of population-level prevention strategies. Thus, a critical next step in the national birth defect research agenda is to better understand the parental and infant determinants of these conditions to identify and implement strategies to reduce birth defect-related morbidity and mortality. As a founding member of the National Birth Defects Prevention Study (i.e., the predecessor of the Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS), the Texas Center for Birth Defects Research and Prevention has helped advance birth defects research and prevention since the founding of the Texas Birth Defects Registry in 1996. The Center represents a collaboration between the Texas Birth Defects Registry at the Texas Department of State Health Services, UTHealth School of Public Health, and Baylor College of Medicine. The addition of our geographic region to BD-STEPS recruitment pool would allow for increased diversity, particularly among Mexican Americans, one of the fastest-growing racial/ethnic groups in the U.S. By leveraging one of the largest birth defects registries in the world, our team has extensive experience in birth defects surveillance and epidemiology, and an exceptional track-record for both generating publications (N>500) that have contributed toward elucidation of birth defects risk factors and training the next generations of birth defects researchers. Building upon our strong infrastructure for patient recruitment, data collection, and epidemiologic analyses, we now propose to contribute our experience and resources to BD-STEPS by collaborating with our long-term partners from other states to advance the study’s data collection and impact, through research and training. Our Center’s particular research areas include 1) social determinants of health (led by the Texas Department of State Health Services); 2) genetic risk factors (led by Baylor College of Medicine); and 3) occupational exposures (led by UT Health School of Public Health). Thus, we are well-positioned to conduct, publish, and present at least seven proposed research studies designed to identify associations with these and other exposures in BD- STEPS and to improve understanding of the specific mechanisms that underlie risk for particular birth defects. At its conclusion, we expect this work will have expanded the list of potentially modifiable maternal exposures that are known to be associated with the risk of birth defects, contributed new knowledge that will aid in the design of risk reduction strategies, and empower the development of doctoral and post-doctoral trainees and junior faculty members. Most importantly, it is expected that these outputs will ultimately translate to a reduction in the prevalence of birth defects and improved health among infants born with these conditions.

项目概要 出生缺陷是美国婴儿死亡率、发病率和医疗费用的一个主要原因，但 对于大多数人来说，这些病症的病因仍然未知，这阻碍了 因此，国家出生缺陷研究议程的下一步关键是。 更好地了解这些情况的父母和婴儿决定因素，以识别和实施 作为国家出生组织的创始成员，制定了减少出生缺陷相关发病率和死亡率的策略。 缺陷预防研究（即评估妊娠暴露的出生缺陷研究的前身） (BD-STEPS)，德克萨斯州出生缺陷研究和预防中心帮助改善出生缺陷 自 1996 年德克萨斯州出生缺陷登记处成立以来，一直致力于研究和预防。该中心代表 德克萨斯州卫生服务部德克萨斯出生缺陷登记处之间的合作， UTHealth 公共卫生学院和贝勒医学院将我们的地理区域添加到其中。 BD-STEPS 招聘池将增加多样性，特别是在墨西哥裔美国人中，这是墨西哥裔美国人之一 通过利用美国最大的出生缺陷登记处之一， 在世界范围内，我们的团队在出生缺陷监测和流行病学方面拥有丰富的经验，并且 两人发表的出版物（N> 500）均拥有出色的记录，这些出版物为阐明 出生缺陷风险因素和培训下一代出生缺陷研究人员。 强大的患者招募、数据收集和流行病学分析基础设施，我们现在建议 通过与其他领域的长期合作伙伴合作，为 BD-STEPS 贡献我们的经验和资源 国家通过我们中心的特殊研究和培训来推进研究的数据收集和影响。 研究领域包括 1) 健康的社会决定因素（由德克萨斯州卫生部牵头） 2) 遗传风险因素（由贝勒医学院主导）和 3) 职业暴露（由贝勒医学院主导）； UT Health 公共卫生学院）因此，我们至少有能力进行、出版和展示。 拟议的研究旨在确定 BD-中这些和其他暴露的七种关联 步骤并提高对特定出生缺陷风险的具体机制的理解。 最后，我们预计这项工作将扩大潜在可改变的孕产妇暴露清单 已知与出生缺陷的风险有关，贡献了新的知识，将有助于 设计降低风险策略，赋能博士、博士后发展 最重要的是，预计这些成果最终将转化为 降低出生缺陷的发生率并改善患有这些疾病的婴儿的健康状况。