FASEB SRC on Acute Kidney Injury: from beside to bench (and back again)

FASEB SRC 关于急性肾损伤：从旁边到替补（然后再回来）

• 批准号: 9752908
• 负责人: Mark P. de Caestecker
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9752908
• 关键词: Academia; Acute Renal Failure with Renal Papillary Necrosis; Age; American; Area; Back; Basic Science; Biological Markers; Career Choice; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Comorbidity; Complex; Development; Diabetes Mellitus; Discipline; Doctor of Philosophy; Drug Screening; Educational workshop; Environment; Female; Fibrosis; Fostering; Functional disorder; Goals; Government; Government Agencies; Hearing; Heterogeneity; Human; Industry; International; Kidney; Marines; Medicine; Molecular; Morbidity - disease rate; Nephrology; Patients; Phenotype; Pre-Clinical Model; Recovery; Research; Research Design; Research Personnel; Risk; Scientist; Societies; Testing; Time; Tissues; Work; Workforce Development; base; bench to bedside; career; clinical phenotype; clinically relevant; data integration; design; drug development; drug discovery; evidence base; human disease; human tissue; injury and repair; innovation; interest; investigator training; meetings; mortality; new technology; novel strategies; novel therapeutic intervention; novel therapeutics; posters; precision medicine; prevent; programs; response; symposium; therapeutic development; translational approach

6. Project Summary/Abstract Acute kidney injury (AKI) is an increasingly prevalent worldwide problem that has a significant impact on patient mortality and morbidity, including a marked increased risk of progressive chronic kidney disease (CKD). AKI is also an active area of basic and clinical research. Despite this, no therapies have been definitively shown to accelerate recovery or prevent progression to CKD in patients with AKI. There are a number of reasons for this, but a major factor is the lack of effective collaborative pipelines between bench researchers studying the mechanisms and new therapeutic approaches to treat AKI, and clinical scientists studying the human disease and implementing hypothesis testing clinical trials to evaluate new therapeutics in patients with AKI. However, aside from the annual scientific meeting of the American Society of Nephrology (ASN), there are few established forums that promote direct exchange of ideas across the clinical and basic science AKI research communities in academia and industry. The concept of this new conference is therefore to develop scientific interactions and collaborations across the bench to bedside divide, and to use this as a forum to help develop a pipeline of investigators trained to think in a more translational way about the problem of AKI. To achieve this, the organizers have designed a three and a half day FASEB Scientific Research Conference. Experts from academic medicine and industry have been invited to provide state of the art talks on key, topical aspects of research in both the basic and clinical science of AKI, as well as recent advances in drug and therapeutic development for AKI. This will also provide the first evidence-based forum to discuss new approaches to study human AKI, and to develop better pre-clinical modeling that reflects the observed cellular and molecular heterogeneity of AKI in humans. We anticipate that this meeting will attract investigators and trainees from academia, industry and government agencies involved in different aspects of AKI research, and as such will provide a unique opportunity to foster new collaborative interactions between these stakeholders.

6. 项目总结/摘要 急性肾损伤（AKI）是一个日益普遍的世界性问题，对患者产生重大影响 死亡率和发病率，包括进行性慢性肾病（CKD）的风险显着增加。 AKI 是 也是基础和临床研究的活跃领域。尽管如此，目前还没有明确的治疗方法可以证明 加速 AKI 患者的康复或预防进展为 CKD。造成这种情况的原因有很多， 但一个主要因素是研究该领域的实验室研究人员之间缺乏有效的合作渠道 治疗 AKI 的机制和新治疗方法，以及研究人类疾病的临床科学家 实施假设检验临床试验来评估 AKI 患者的新疗法。然而， 除了美国肾脏病学会 (ASN) 的年度科学会议外，很少有既定的会议 促进临床和基础科学 AKI 研究社区直接交流思想的论坛 在学术界和工业界。因此，这次新会议的理念是发展科学 跨工作台到床边的互动和协作，并以此为论坛来提供帮助 培养一批经过培训的调查人员，以更加转化的方式思考 AKI 问题。 为了实现这一目标，主办方设计了为期三天半的FASEB科学研究会议。 来自医学界和工业界的专家受邀就关键、专题提供最先进的演讲 AKI 基础和临床科学研究的各个方面，以及药物和治疗的最新进展 AKI 的治疗开发。这也将提供第一个基于证据的论坛来讨论新的 研究人类 AKI 的方法，并开发更好的临床前模型来反映观察到的细胞 以及人类 AKI 的分子异质性。我们预计这次会议将吸引调查人员和 来自学术界、工业界和政府机构的学员参与 AKI 研究的不同方面，以及 因此，这将为促进这些利益相关者之间新的协作互动提供独特的机会。