Power Analysis for Meta Analysis

元分析的功效分析

• 批准号: 7452499
• 负责人: Michael Borenstein
• 金额: $ 44.34万
• 依托单位: BIOSTATISTICAL PROGRAMMING ASSOC, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7452499
• 关键词: Address; Adolescence; Analysis of Variance; Applications Grants; Attention; Behavioral; Books; Budgets; Case Study; Childhood; Clinical; Code; Complex; Computer Simulation; Computer software; Data; Databases; Decision Making; Development Plans; Discipline; Disease; Disease regression; Educational workshop; Effect Modifiers (Epidemiology); Ensure; Funding; Funding Agency; Goals; Grant; Graph; Hand; Heterogeneity; Humor; Intervention; Investments; Journals; Logic; Medicine; Mentors; Meta-Analysis; Methodology; Modeling; New Jersey; Numbers; Odds Ratio; Operative Surgical Procedures; Paper; Pharmaceutical Preparations; Play; Policies; Prevalence; Prevention; Process; Publishing; Range; Rate; Relative (related person); Reporting; Research; Research Personnel; Resources; Review, Systematic (PT); Risk; Role; Sample Size; Series; Social Sciences; Standards of Weights and Measures; Statistically Significant; Subgroup; Substance abuse problem; Testing; Text; Thinking; Time; Today; Trademark; United States National Institutes of Health; Update; Work; Writing; addiction; base; computer program; cost; cost effectiveness; design; handbook; hazard; inclusion criteria; indexing; novel; programs; size; social; software development; success; symposium; treatment effect

DESCRIPTION (provided by applicant): Meta-analysis plays a key role in setting policy and in planning new research. In the field of substance abuse prevention, meta-analyses have been used to determine the relative impact of competing treatments for addiction, to estimate prevalence of addiction-related diseases, to plan targeted interventions, to assess the cost-effectiveness of competing treatments, and to assist in planning more effective research. A systematic review and meta-analysis requires a substantial investment of time and resources. The time required is typically a year or more, and the cost can exceed a million dollars. Therefore, before embarking on a systematic review the researcher should conduct a power analysis to ensure that the review will have appropriate statistical power to yield a meaningful result. At present however, while the formulas for this kind of power analysis have been published, no mechanism exists for actually applying these formulas. The goal of this project is to develop software to compute power for meta-analysis. The program would be used to plan a new systematic review, to understand the implications of a completed review, to make decisions about updating a review with the inclusion of new studies, and to plan a set of primary studies that would be synthesized by meta-analysis. It will incorporate a sophisticated user interface to address the kinds of real-world issues that must be addressed in a power analysis. Meta-analysis plays a key role in setting policy and in planning new research. In the field of substance abuse prevention, for example, meta-analyses have been used to determine the relative impact of competing treatments for addiction. The goal of this project is to develop software to compute power for meta-analysis. The program would be used to plan a new systematic review and to understand the implications of a completed review.

描述（由申请人提供）：荟萃分析在制定政策和计划新研究中起关键作用。在预防药物滥用领域，荟萃分析已被用来确定竞争性治疗对成瘾的相对影响，估计成瘾相关疾病的普遍性，以计划有针对性的干预措施，评估竞争治疗的成本效益，并协助计划更多有效的研究。系统的审查和荟萃分析需要大量时间和资源投资。所需的时间通常是一年或更长时间，成本可能超过一百万美元。因此，在进行系统评价之前，研究人员应进行功率分析，以确保审查具有适当的统计能力以产生有意义的结果。然而，目前，尽管已经发布了这种功率分析的公式，但尚无实际应用这些公式的机制。该项目的目的是开发软件以计算荟萃分析的功率。该计划将用于计划一项新的系统审查，以了解完整的审查的含义，以决定在包含新研究的情况下更新审查，并计划通过荟萃分析综合的一系列主要研究。它将结合一个复杂的用户界面，以解决功能分析中必须解决的现实世界问题。荟萃分析在制定政策和计划新研究中起着关键作用。例如，在预防药物滥用领域中，荟萃分析已用于确定竞争性治疗对成瘾的相对影响。该项目的目的是开发软件以计算荟萃分析的功率。该计划将用于计划新的系统审查，并了解完成的审查的含义。