A Multi-Modal Investigation of Neurophysiological Deficits in PTSD

PTSD 神经生理缺陷的多模式研究

• 批准号: 10762150
• 负责人: Antonia Seligowski
• 金额: $ 10.78万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2023-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10762150
• 关键词: Address; Administrative Supplement; Anterior; Biological Assay; Brain region; Diagnosis; Disease; Dorsal; Estradiol; Exhibits; Fright; Gender; Goals; Gonadal Steroid Hormones; Investigation; Knowledge; Parents; Post-Traumatic Stress Disorders; Prefrontal Cortex; Progesterone; Research; Rest; Risk; Role; Sampling; Sex Differences; Strategic Planning; Testing; Testosterone; United States National Institutes of Health; Woman; Women' s Health; cingulate cortex; insight; men; multimodality; neurophysiology; recruit; sex

Project Summary Women are twice as likely as men to be diagnosed with posttraumatic stress disorder (PTSD), and sex hormones have been implicated in this difference. While research has begun to elucidate neurophysiological contributions to PTSD, there is a dearth of knowledge regarding how sex hormones influence these dynamics to confer greater risk among women. For example, while PTSD is generally associated with increased resting state activity of the dorsal anterior cingulate cortex (dACC) and decreased activity of the ventromedial prefrontal cortex (vmPFC), women may exhibit lower activity in these regions compared to men. Other research has shown that PTSD is associated with decreased functional connectivity of frontal brain regions. However, no prior research has tested dACC-vmPFC functional connectivity in men versus women, which could provide insight into mechanisms underlying PTSD sex differences. Further, low estradiol and high progesterone have been associated with worse fear inhibition in women with PTSD, and testosterone levels have been implicated in PTSD among men, though findings are mixed. No prior studies have examined how sex hormone levels modulate dACC-vmPFC activity or functional connectivity in PTSD, and no studies have compared these effects in men versus women. This proposed supplement will directly address these gaps by adding a new sample of men to the ongoing Parent K23 study, as well as by adding testosterone assays to existing assays of estradiol and progesterone. By examining the effects of sex hormones (estradiol, progesterone, testosterone) in both men and women, this proposal will characterize the role of sex in the neurophysiological deficits seen in PTSD. The proposed supplement will be embedded within the existing Parent K23 study, which has recruited 60 women thus far. The supplement will include a new sample of 30 men with PTSD. The goals of the Parent K23 and this proposed supplement are directly in line with Strategic Goal 1 of the 2019-2023 Trans- NIH Strategic Plan for Women's Health Research: “Advance rigorous research that is relevant to the health of women.” In particular, Objective 1.2 is to “Investigate the influence of sex and gender on disease presentation,” and the proposed supplement will probe the role of three different sex hormones (sex) on neurophysiological deficits in both men and women with PTSD.

项目摘要 女性被诊断为创伤后应激障碍（PTSD）和性激素的可能性是男性的两倍 在研究开始阐明神经栖息地的贡献时，已经与此差异有关。 对于PTSD，关于性激素如何影响这些动力以赋予更大的知识缺乏知识 例如，女性的风险。 背前扣皮酸酯皮层（DACC）和腹侧前额叶皮层（VMPFC）的活性降低 在这些地区，妇女可能表现出较低的活性。 与额叶区域的功能连接降低相关。 在男性与女性中测试过的DACC-VMPFC功能连接连接器 PTSD性别差异的基础机制。 与PTSD女性和睾丸激素水平的恐惧率更严重有关 男性中的PTSD，尽管没有研究结果。 PTSD中连接的模块化DACC-VMPFC活性或功能性，没有研究比较这些 男性与女性的影响。 对正在进行的父母K23研究的男性样本，以及通过在现有测定中添加睾丸激素测定法 雌二醇和孕酮。 男性和女人，该提议都将表征性别在神经生理缺陷中的作用 在PTSD中可见。 到目前为止，招募了60名女性 父级K23和支撑型糖果直接与2019 - 2023年Trans-的战略目标1一致 NIH妇女健康研究的战略计划：“与健康健康有关的严格研究” 女性。 而支撑的补充剂将探究不同性激素（性别）在 具有PTSD的男性和女性的神经生理学缺陷。