Nitric oxide Releasing Ultra-Slippery Antibacterial Surfaces for Urological Catheter Applications

用于泌尿导管应用的一氧化氮释放超光滑抗菌表面

• 批准号: 10759903
• 负责人: Ronald J. Shebuski
• 金额: $ 33.74万
• 依托单位: NYTRICX INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10759903
• 关键词: Adhesions; Affect; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Therapy; Bacteremia; Bacteria; Bacterial Adhesion; Bacteriuria; Biocompatible Materials; Biological; Businesses; Cannulas; Catheterization; Catheters; Cell Line; Cell Survival; Chronic; Clinical; Data; Development; Devices; Disinfection; Elderly; Ensure; Escherichia coli; Formulation; Fortune; Goals; Growth; Guidelines; Health Care Costs; Hospitalization; Hospitals; Human; In Vitro; Industrialization; Indwelling Catheter; Infection; Inflammation; Infusion procedures; Kidney; Lead; Length of Stay; Letters; Liquid substance; Malignant neoplasm of urinary bladder; Mammalian Cell; Marketing; Mechanics; Medical; Medical Device; Methods; Microbial Biofilms; N-acetylpenicillamine; Nitric Oxide; Nitric Oxide Donors; Nursing Homes; Operative Surgical Procedures; Patients; Peritoneal Dialysis; Phase; Polymers; Population; Probability; Procedures; Property; Proteins; Proteus mirabilis; Pyelonephritis; Risk; Silicone Oils; Small Business Innovation Research Grant; Surface; Surface Properties; Technology; Tube; United States National Institutes of Health; Urinary Catheterization; Urinary Incontinence; acute pyelonephritis; aging population; antimicrobial; catheter associated UTI; commercialization; cooking; cytotoxic; endotracheal; experience; healthcare-associated infections; infection risk; insight; interest; mechanical properties; medical complication; prevent; response; urinary; urologic

Abstract Urinary catheters are one of the most widely used medical devices in a hospital setting and are expected to only increase in growth due to the aging population. Out of all the various biomedical devices that are frequently used in a clinical setting, urinary catheters are associated with the largest portion of medical complications related to infection. Catheter associated urinary tract infections (CAUTIs) account for nearly 40% of all healthcare associated infections (HAIs) and can lead to extended hospital stays for patients which in turn leads to higher healthcare costs. To overcome this risk of infection, a catheter surface that is able to prevent bacterial adhesion and biofilm formation while simultaneously eliminating planktonic bacteria present in the vicinity is highly desirable. However, no long-term catheter solution has been able to accomplish this goal. Nytricx, Inc. has developed proprietary methods and know-how developing anti-infective nitric oxide (NO) releasing interfaces capable of effectively eliminating a wide variety of bacterial strains while being able to elicit no cytotoxic response from mammalian cell lines. Nytricx, Inc. has also demonstrated that the liquid-infusion of silicone oil to create a super slippery surface is able to prevent the adhesion of proteins and bacteria and thus eliminate biofilms. A synergistic antimicrobial response is achieved by combining liquid-infused strategy and NO releasing polymers (LINORel). The overall objective of this Phase I SBIR application is to create a long-term highly antimicrobial urinary catheter through a combination of impregnating Foley catheters with a NO donor, S-nitroso-N- acetylpenicillamine (SNAP), with a liquid-infused silicone oil interface and to evaluate commercialization feasibility in terms of mechanical and biological properties.

抽象的 尿导管是医院环境中使用最广泛的医疗设备之一，预计仅 由于人口老龄化而增加的增长。在所有经常使用的生物医学设备中 在临床环境中，尿导管与与 感染。导管相关的尿路感染（CAUTIS）占所有医疗保健的近40％ 相关感染（HAI），可能导致患者的住院延长，从而导致更高 医疗保健费用。为了克服这种感染的风险，能够防止细菌粘附的导管表面 生物膜形成同时消除附近存在的浮游细菌 理想。但是，没有长期导管解决方案能够实现这一目标。 Nytricx，Inc。拥有 开发的专有方法和专有技术发展抗感染一氧化氮（NO）释放界面 能够有效消除各种细菌菌株，同时不引起细胞毒性反应 来自哺乳动物细胞系。 Nytricx，Inc。还证明了硅油的液体输注以创建 超滑面能够防止蛋白质和细菌的粘附，从而消除生物膜。一个 通过结合液体注入策略和无释放聚合物来实现协同抗菌反应 （布线）。该阶段I SBIR应用的总体目标是创建长期高度抗菌剂 通过浸渍Foley导管与无供体S-硝基-N-的结合结合的尿导管 乙酰苯丙胺（SNAP），具有液态硅油界面并评估商业化 在机械和生物学特性方面的可行性。