The Rapid-Production of the High-Performance and Affordable Cadmium Telluride and Cadmium Zinc Telluride for Medical Imaging Applications.

快速生产用于医学成像应用的高性能且经济实惠的碲化镉和碲化镉锌。

• 批准号: 10761330
• 负责人: LARS R FURENLID
• 金额: $ 102.49万
• 依托单位: RADIATION DETECTION TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10761330
• 关键词: Acceleration; Businesses; CdZnTe; Chlorine; Clinical; Collection; Commercial grade; Densitometry; Dental; Detection; Devices; Diagnostic Imaging; Discipline of Nuclear Medicine; Gamma Rays; Government; Growth; Hour; Hybrids; Image; Imaging Device; Industrialization; Industry; Laboratory Research; Marketing; Medical; Medical Imaging; Methods; Oncology; Outcome; Pattern; Performance; Phase; Photons; Positron-Emission Tomography; Price; Process; Production; Property; Radiation; Radiation Dose Unit; Resolution; Roentgen Rays; Rotation; Security; System; Techniques; Temperature; Time; Travel; United States; United States National Institutes of Health; Validation; X-Ray Computed Tomography; X-Ray Medical Imaging; bone; cadmium telluride; commercialization; cost; crystallinity; design; imaging system; improved; instrumentation; interest; manufacture; melting; next generation; operation; prototype; radiation detector; technological innovation

1 The high spatial-resolution and energy-resolution of cadmium zinc telluride (CZT) and cadmium telluride 2 (CdTe), compared to that of scintillators, offers superior image quality in Nuclear medicine and X-ray 3 imaging applications, i.e. SPECT, PET, CT, Bone Densitometry, Oncology, Dental imaging, Airport 4 security, etc. CZT and CdTe remain the desired choice for room-temperature radiation detection, but it is 5 limited by high-cost and availability resulting from low yield and long production times associated with 6 commercial growth techniques, i.e. the Traveling Heater Method (THM). However, the application of the 7 Accelerated Crucible Rotation Technique (ACRT) growth method developed at WSU has proven to 8 produce industrial quality, high-performance CdTe/CZT. This recently developed growth method not only 9 allows CdTe/CZT to be grown with the same quality as material grown by THM, but also at growth rates 10 approximately 10-20 times faster than THM. Specifically, CdTe/CZT is grown by THM at a rate of 11 approximately 1-3 mm per day, whereas CdTe/CZT growth by ACRT can be accomplished at much faster 12 rates of approximately 1-3 mm per hour. THM-grown CdTe/CZT requires a lower growth temperature for 13 high-quality devices, which results in highly off-stoichiometric melts, thereby inducing the need for 14 postprocessing. These major challenges associated with the crystal growth of CdTe/CZT have been 15 overcome using ACRT. It is proposed here to further develop the ACRT growth process by introducing 16 crystal seeding in the ACRT system for CdTe and scale this process to commercial-grade levels while 17 continuing to improve the CdTe device properties for high-flux SPECT/CT applications. Chlorine doping 18 will be further explored and optimized to achieve high resistivity and high mobility-lifetime CdTe devices. 19 Numerous CdTe:Cl ingots will be grown, and devices will be produced from these ingots (cross strip and 20 commercial pixel patterns). Devices will be sent to commercial partners and customers for validation in 21 effort to integrate into commercial imaging systems. A prototype SPECT/CT system will be designed, built, 22 and images will be collected. The medical/diagnostic imaging market is projected to cross $55.7 billion by 23 2025. Stakeholders in the medical imaging market need CdTe/CZT devices now. The fruition of this project 24 will be a significant reduction (>3x) of industrial-grade material costs by increasing the yield, reducing the 25 growth time, and eliminating post-growth anneal treatments currently used by industry. With the fast- 26 production time and high-performance of the CdTe/CZT produced in this effort, (1) the medical imaging 27 market will finally have a fast turnaround time and consistent high-performance material that can easily be 28 obtained, (2) a >3x price reduction is projected for CdTe/CZT, and (3) Stakeholders will have access to an 29 affordable, high-performance CdTe/CZT material that can be obtained for imaging instrumentation and 30 other radiation detection applications.

1 碲化镉锌(CZT)和碲化镉的高空间分辨率和能量分辨率 2 (CdTe) 与闪烁体相比，在核医学和 X 射线领域提供卓越的图像质量 3 种成像应用，即 SPECT、PET、CT、骨密度测定、肿瘤学、牙科成像、机场 4 安全性等。CZT 和 CdTe 仍然是室温辐射检测的理想选择，但它 5 因产量低且生产时间长而导致高成本和可用性的限制 6 种商业生长技术，即移动加热器法 (THM)。然而，应用 7 华盛顿州立大学开发的加速坩埚旋转技术 (ACRT) 生长方法已被证明可以 8 生产工业品质的高性能CdTe/CZT。这种最近开发的生长方法不仅 9 允许 CdTe/CZT 的生长质量与 THM 生长的材料相同，而且生长速率也相同 10 大约比 THM 快 10-20 倍。具体来说，CdTe/CZT 通过 THM 以以下速率生长 11 每天大约 1-3 毫米，而 ACRT 的 CdTe/CZT 生长速度可以更快 12 速率约为每小时 1-3 毫米。 THM 生长的 CdTe/CZT 需要较低的生长温度 13 个高质量设备，导致高度偏离化学计量的熔体，从而导致需要 14 后处理。与 CdTe/CZT 晶体生长相关的这些主要挑战 15 使用 ACRT 克服。这里建议通过引入进一步发展 ACRT 生长过程 在 CdTe 的 ACRT 系统中进行 16 个晶种，并将该工艺扩展到商业级水平，同时 17 继续改进高通量 SPECT/CT 应用的 CdTe 器件性能。氯掺杂 18将进一步探索和优化，以实现高电阻率和高迁移率寿命的CdTe器件。 19 将生长大量的 CdTe:Cl 锭，并用这些锭生产器件（交叉带和 20 个商业像素图案）。设备将被发送给商业合作伙伴和客户进行验证 21 努力融入商业成像系统。将设计、建造原型 SPECT/CT 系统， 22 并且将收集图像。医疗/诊断成像市场预计到 2020 年将突破 557 亿美元 2025 年 23 日。医学成像市场的利益相关者现在需要 CdTe/CZT 设备。这个项目的成果 24 通过提高产量、降低 25 的生长时间，并消除了行业目前使用的生长后退火处理。随着快速- 26 本次工作中生产的 CdTe/CZT 的生产时间和高性能，(1) 医学成像 27 市场最终将拥有快速的周转时间和一致的高性能材料，可以轻松地 28 获得，(2) 预计 CdTe/CZT 价格将下降 3 倍以上，(3) 利益相关者将有机会获得 29 种经济实惠的高性能 CdTe/CZT 材料，可用于成像仪器和 30 种其他辐射检测应用。