Cannabis Use and Proximal Immune Dysregulation (CUPID)

大麻使用和近端免疫失调（CUPID）

基本信息

批准号：
10760742
负责人：
Renessa Williams
金额：
$ 16.41万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-25 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10760742
关键词：
Acceleration Address Adolescent Age Anti-Inflammatory Agents Attenuated Biological Biological Markers Biological Process Black Populations Black race CD4 Lymphocyte Count Cannabis Cell Aging Chicago Chromosomes Chronic stress Cohort Studies Communities Complement Cross-Sectional Studies DNA Structure Data Demographic Survey Development Discrimination Disease Epidemic Exposure to Funding Gays Generations Goals HIV HIV Infections HIV disparities Health Homophobia Housing Immune Immune system Individual Inflammation Inflammatory Infrastructure Investigation Legal Length Lesbian Gay Bisexual Transgender Queer Leukocytes Life Life Cycle Stages Life Expectancy Link Measures Mental Health Mentors Mentorship Modeling Morbidity - disease rate Neighborhoods Neuroimmune Not Hispanic or Latino Occupations Outcome Parents Participant Pathogenesis Pathway interactions Patient Self-Report Persons Pharmacology Plasma Play Population Predisposition Process Property Research Research Activity Research Personnel Risk Role Sampling Severities Social Conditions Stress Stress and Coping Symptoms Therapeutic Training Training Activity United States National Institutes of Health Untranslated RNA Urine Victimization Violence Viral Load result Weather Work age related biobehavior black men career career development cohort comorbidity critical period early life exposure emerging adulthood experience fortification health disparity internalized stigma longitudinal analysis marijuana use men minority stress monocyte mortality physical conditioning preservation racial disparity racial minority racism sexual identity sexual minority group sexual minority men sexual minority stress sleep health social social health determinants social stigma sociodemographics stimulant use telomere therapy development

项目摘要

PROJECT SUMMARY/ABSTRACT Background. Black sexual minority men (SMM) experience profound HIV-related disparities compared to non- Hispanic White men, acquiring age-related diseases with greater symptom severity earlier in the life course and dying from HIV infection at higher rates. Early life exposure to stress is linked to key biological processes, specifically inflammation and shorter leukocyte telomere length, which are associated with HIV-related comorbidities and age-related diseases. It is well documented that young Black SMM experience multilevel sexual minority stress, such as sexual identity concealment, victimization, and community homophobia - products of stigma which further complicate health outcomes. Thus, understanding factors that may attenuate the effects of inflammation in younger ages is a critical period to mitigate HIV-related disparities later in life. Cannabis use is a noteworthy modifiable factor for investigation, given the substantial evidence of its role in anti- inflammatory processes and its rapidly accelerating legal and social acceptance; however, the rigor of prior research examining the influence of cannabis on inflammation and other key biological processes is limited because studies have mostly been cross-sectional, used self-reported measures of cannabis use, and are not generalizable to young Black SMM with HIV. To address these gaps, this K23 proposal – Cannabis Use and Proximal Immune Dysregulation (CUPID) – will fortify my Career Development efforts to (1) understand how biomarkers of cannabis may influence inflammation and leukocyte telomere length and (2) examine the modifying role of multilevel sexual minority stress. This K23 proposal will chart a pathway to achieve my long- term Career Goals of becoming an R01-funded investigator with expertise in multilevel determinants of biobehavioral processes underpinning HIV-related health disparities to guide the development of interventions with Black SMM with HIV. To accomplish my career goals, I will need training (1) to develop a comprehensive understanding of biomarkers of cannabis use, inflammation, and leukocyte telomere length; (2) to advance my understanding of multilevel sexual minority stress assessment in Black SMM; and (3) to develop expertise in analyzing longitudinal data. An accomplished, interdisciplinary Mentorship Team committed to supporting my transition to an independent investigator will provide guidance on the training and research activities. Specific Aims are (1) to determine the relationship between cannabis use and biomarkers of inflammation and leukocyte telomere length; and (2) to evaluate whether individual- interpersonal- community- and societal level sexual minority stress moderate the relationship of cannabis with inflammation and leukocyte telomere length. CUPID will inform the development of an R01 proposal for a more definitive cohort study to further elucidate the bio- behavioral pathways whereby cannabis use, and sexual minority stress are linked to inflammation and leukocyte telomere length in Black SMM with HIV.

项目概要/摘要背景：与非性少数群体相比，黑人性少数群体经历着与艾滋病毒相关的巨大差异。西班牙裔白人男性在生命历程的早期就患有与年龄相关的疾病，症状更严重，并且死于艾滋病毒感染的比率较高，生命早期暴露于压力与关键的生物过程有关，特别是炎症和白细胞端粒长度缩短，这些与 HIV 相关有据可查的是，年轻的黑人 SMM 会经历多层次的合并症和年龄相关疾病。性少数压力，例如隐瞒性身份、受害和社区恐同症 - 耻辱的产物使健康结果进一步复杂化，因此，了解可能减弱的因素。年轻时炎症的影响是减轻晚年与艾滋病毒相关的差异的关键时期。鉴于有大量证据表明大麻在抗击炎症过程及其迅速加速的法律和社会接受；然而，先前的严格性检验大麻对炎症和其他关键生物过程影响的研究有限因为研究大多是横断面的，使用自我报告的大麻使用措施，而不是为了解决这些差距，这项 K23 提案 – 大麻的使用和近端免疫失调（CUPID）——将加强我的职业发展努力，以（1）了解如何大麻的生物标志物可能会影响炎症和白细胞端粒长度，并且（2）检查改变多层次性少数压力的作用。这项 K23 提案将为实现我的长期目标指明道路。术语职业目标是成为一名 R01 资助的研究人员，具有多层次决定因素方面的专业知识支持艾滋病毒相关健康差异的生物行为过程，以指导干预措施的制定为了实现我的职业目标，我需要培训 (1) 来制定全面的计划。了解大麻使用、炎症和白细胞端粒长度的生物标志物（2）以提高我的水平；了解黑人 SMM 中的多层次性少数压力评估；以及 (3) 发展以下方面的专业知识：纵向分析数据。一个卓有成效的跨学科指导团队致力于支持我的工作。过渡为独立研究者将为培训和研究活动提供具体指导。目的是 (1) 确定大麻使用与炎症和白细胞生物标志物之间的关系 (2) 评估个人-人际-社区-和社会层面的性是否存在少数压力调节大麻与炎症和白细胞端粒长度的关系。将通知 R01 提案的制定，以进行更明确的队列研究，以进一步阐明生物- 大麻使用的行为途径和性少数压力与炎症和白细胞有关感染艾滋病毒的黑人 SMM 的端粒长度。