Analytical Biochemistry

分析生物化学

• 批准号: 9634852
• 负责人: Douglas Yee
• 金额: --
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9634852
• 关键词: 1,3-Butadiene; 2-butenal; Acetylcysteine; Acrolein; Analytical Biochemistry; Analytical Chemistry; Aromatic Polycyclic Hydrocarbons; Benzene; Biological; Biological Markers; Butanones; Cancer Center; Cancer Center Support Grant; Carcinogens; Cardiovascular system; Chemoprevention; Chromatography; Consult; Contract Services; Coupled; DNA Adducts; Doctor of Philosophy; Equipment; Ethylene Oxide; Etiology; Funding; Gas Chromatography; Glucuronides; Head; High Pressure Liquid Chromatography; Human Resources; Liquid Chromatography; Maintenance; Malignant Neoplasms; Mass Spectrum Analysis; Mission; N' -nitrosonornicotine; Nature; Nicotine; Nitrosamines; Nucleic Acids; Nucleosides; Oligonucleotides; Organic Chemistry; Peptides; Plasma; Prevention; Proteins; Proteomics; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Scientist; Services; Site; Techniques; Time; Tobacco; Tobacco-Associated Carcinogen; Universities; Urine; carcinogenesis; cost; cost effective; cost efficient; design; experience; instrument; instrumentation; mass spectrometer; member; method development; operation; programs; repaired; small molecule; tobacco toxicant; toxicant; urinary

The mission of the Analytical Biochemistry Shared Resource is to provide high-quality analytical services to members of the Masonic Cancer Center (MCC) by providing state-of-the-art chromatographic, mass spectrometric, and related techniques, in a timely and cost-efficient manner. The Resource provides • mass spectrometry services • analytical biochemistry services, emphasizing tobacco carcinogen and toxicant biomarker analyses • chromatography services: on-site consulting for the maintenance and service of high-performance liquid chromatography and gas chromatography equipment Stephen Hecht, PhD, the director of Analytical Biochemistry, has many years of experience in analytical organic chemistry and mass spectrometry. Four other staff members also bring decades of experience with mass spectrometry (Dr. Peter Villalta and Brock Matter), nicotine metabolites (Dr. Sharon Murphy), and chromatography (Steven Carmelia). Analytical Biochemistry remains an outstanding and extensively used resource that serves members of almost all of the MCC Programs as well as other researchers at the University. The specialized nature of the facility enables services to be provided at very cost-effective rates, while providing users access to equipment in a timely manner. Most instruments are maintained and repaired by Resource staff, avoiding the need for costly service contracts. Members of the MCC rely on Analytical Biochemistry staff for guidance on related projects, method development, and troubleshooting of instruments. This heavily used and technically outstanding facility continues to provide crucial services to its highly productive users.

分析生物化学共享资源的使命是提供高质量的分析服务 共济会癌症中心 (MCC) 的成员通过提供最先进的色谱、质量 该资源及时且经济高效地提供了光谱分析和相关技术。 • 质谱服务 • 分析生物化学服务，强调烟草致癌物和有毒生物标志物分析 • 色谱服务：高性能色谱仪维护和服务的现场咨询 液相色谱和气相色谱设备 Stephen Hecht 博士，分析生物化学主任，拥有多年分析经验 其他四名工作人员也拥有数十年的有机化学和质谱经验。 质谱分析（Peter Villalta 博士和 Brock Matter）、尼古丁代谢物（Sharon Murphy 博士）和 色谱法（Steven Carmelia）仍然是一种杰出且常用的方法。 为几乎所有 MCC 项目的成员以及该中心的其他研究人员提供服务的资源 大学的设施的专业性使得能够以非常具有成本效益的价格提供服务， 同时为用户提供及时使用设备的机会，并维护和修理大多数仪器。 由资源人员提供，避免了 MCC 成员依赖 Analytical 的昂贵服务合同。 生物化学人员为相关项目、方法开发和仪器故障排除提供指导。 这个使用率很高且技术卓越的设施继续为其高度重视的客户提供关键服务。 富有成效的用户。