Metabolic Adaptations to Two Year Caloric Restriction

对两年热量限制的代谢适应

基本信息

批准号：
7364619
负责人：
Eric Ravussin
金额：
$ 109.46万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-03-15 至 2009-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7364619
关键词：
Address Adipose tissue Adrenal Glands Adult Affect Aging Animal Model Autonomic nervous system Behavioral Birth Body Temperature Body Weight Body Weight decreased Caloric Restriction Candidate Disease Gene Carbohydrates Cardiovascular Diseases Cardiovascular system Chronic Chronic Disease Circadian Rhythms DNA Diabetes Mellitus Disease Drops Eating Disorders Endocrinologist Energy Intake Energy Metabolism Exercise Food Gene Expression Hemostatic function Homocysteine Homocystine Human Hypothalamic structure Inflammation Insulin Investigation Leptin Life Lipids Longevity Lower Organism Macaca mulatta Maintenance Measurement Measures Metabolic Metabolic Diseases Metabolism Molecular Moods Neurosecretory Systems Non-Insulin-Dependent Diabetes Mellitus Outcome Overweight Oxidative Stress Physical Fitness Physical activity Primates Production Proteins Psychologist Quality of life Rate Reaction Time Records Relative (related person)Rest Risk Risk Factors Rodent Signal Transduction Single-Blind Study Skeletal Muscle Surrogate Markers Sympathetic Nervous System Testing Thyroid Function Tests Tissues age related cardiovascular disorder risk cognitive function diabetes risk energy balance fitness improved interest longevity gene mortality multidisciplinary neuronal cell body nonhuman primate protein metabolism repaired research study response sedentary sensory neuron specific sodium channel size volunteer

项目摘要

DESCRIPTION: (provided by applicant) Calorie restriction (CR) is known to extend the lifespan of rodents and several ?lower? species, and to improve surrogate markers for longevity and mortality in rhesus monkeys. There is, however, a paucity of reliable information on whether this is the case in humans as well. In response to a specific RFA from the NIA for descriptive experiments to address this issue, we propose a controlled, single-blinded study of several adaptive responses pertinent to this question in overweight volunteers imposed an initial 25% negative energy balance for two years by CR alone or by CR with additional physical activity. These responses include changes in energy metabolism, surrogate markers of oxidative stress and risks for cardiovascular disease and type-2 diabetes mellitus, neuroendocrine functions and autonomic nervous system activity, expression of candidate genes involved in energy metabolism, oxidative stress and longevity, and quality of life and physical fitness. In addition to descriptive information, we will test the hypotheses that CR with weight loss and maintenance of energy balance at a new body weight: 1. Lowers absolute and relative rates of energy expenditure and body temperature and decreases evidence of tissue oxidative stress. 2. Improves surrogate markers for cardiovascular disease and type-2 diabetes mellitus. 3. Affects the diurnal secretion of leptin leading to adaptations in the neuroendocine and autonomic nervous system enhance soma maintenance. 4. Alters the expression of genes involved in energy/protein metabolism, the production and clearance of reactive species, and ?longevity? genes in a fashion consistent with animal models of CR. 5. Improves the quality of life and metabolic fitness. A multidisciplinary team, including physiologists, behavioral psychologists, endocrinologists, molecular biologists and geneticists will conduct this study.

描述：（由申请人提供）已知卡路里限制 (CR) 延长啮齿类动物的寿命并降低数倍？种，并改进恒河猴寿命和死亡率的替代标记。有，然而，缺乏关于这是否属于这种情况的可靠信息。人类也是如此。回应 NIA 的具体 RFA 描述性内容为了解决这个问题，我们提出了一种受控的、单盲的实验对与超重问题相关的几种适应性反应的研究 CR 志愿者在两年内施加了初始 25% 的负能量平衡单独或通过 CR 结合额外的体力活动。这些回应包括能量代谢的变化、氧化应激和风险的替代标志物用于心血管疾病和2型糖尿病、神经内分泌功能和自主神经系统活动，候选基因的表达参与能量代谢、氧化应激和长寿以及生命质量生活和身体素质。除了描述性信息外，我们还将测试 CR 具有减肥和维持能量平衡的假设新体重： 1. 降低能量消耗和身体的绝对和相对率温度并减少组织氧化应激的证据。 2. 改善心血管疾病和2型糖尿病的替代标志物梅利图斯。 3. 影响瘦素的昼夜分泌，从而导致适应神经内分泌和自主神经系统增强躯体维持。 4. 改变参与能量/蛋白质代谢的基因的表达，活性物质的产生和清除以及“寿命”基因在一个时尚与CR的动物模型一致。 5. 提高生活质量和代谢健康。多学科团队，包括生理学家、行为心理学家、内分泌学家、分子生物学家和遗传学家将进行这项研究。

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss.

DOI：
10.1371/journal.pone.0004377
发表时间：
2009
期刊：
PloS one
影响因子：
3.7
作者：
Redman LM;Heilbronn LK;Martin CK;de Jonge L;Williamson DA;Delany JP;Ravussin E;Pennington CALERIE Team
通讯作者：
Pennington CALERIE Team

Calorie restriction and bone health in young, overweight individuals.

DOI：
10.1001/archinte.168.17.1859
发表时间：
2008-09-22
期刊：
ARCHIVES OF INTERNAL MEDICINE
影响因子：
0
作者：
Redman, Leanne M.;Rood, Jennifer;Anton, Stephen D.;Champagne, Catherine;Smith, Steven R.;Ravussin, Eric
通讯作者：
Ravussin, Eric

The effect of caloric restriction interventions on growth hormone secretion in nonobese men and women.

DOI：
10.1111/j.1474-9726.2009.00530.x
发表时间：
2010-02
期刊：
Aging cell
影响因子：
7.8
作者：
Redman LM;Veldhuis JD;Rood J;Smith SR;Williamson D;Ravussin E;Pennington CALERIE Team
通讯作者：
Pennington CALERIE Team

Impact of 6-month caloric restriction on autonomic nervous system activity in healthy, overweight, individuals.

DOI：
10.1038/oby.2009.408
发表时间：
2010-02
期刊：
OBESITY
影响因子：
6.9
作者：
de Jonge, Lilian;Moreira, Emilia A. M.;Martin, Corby K.;Ravussin, Eric
通讯作者：
Ravussin, Eric

In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets.

DOI：
10.1371/journal.pone.0003211
发表时间：
2008-09-15
期刊：
PloS one
影响因子：
3.7
作者：
Allard JS;Heilbronn LK;Smith C;Hunt ND;Ingram DK;Ravussin E;Pennington CALERIE Team;de Cabo R
通讯作者：
de Cabo R