Pennington/Louisiana NORC - Admin Supplement for Pilot and Feasibility studies 2021

彭宁顿/路易斯安那州 NORC - 2021 年试点和可行性研究行政补充

• 批准号: 10399166
• 负责人: Eric Ravussin
• 金额: $ 14.8万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10399166
• 关键词: Address; Adult; Advertising; Age; Animal Model; Applications Grants; Area; Award; Back; Basic Science; Binding; Centers of Research Excellence; Childhood; Chronic Disease; Clinical; Clinical Sciences; Collaborations; Data; Development; Direct Costs; Discipline; Disease; Environment; Equipment; Faculty; Feasibility Studies; Felis catus; Fostering; Funding; Future; Goals; Grant; Health; Health Sciences; Human; Human Resources; Impairment; Incentives; Infant; Infrastructure; Institution; Intervention; Life Cycle Stages; Life Style Modification; Longevity; Louisiana; Malignant Neoplasms; Medical; Mentors; Mentorship; Metabolic; Metabolic syndrome; Methods; Minority; Minority Groups; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Nutritional Science; Nutritional status; Obesity; Phenotype; Physical Function; Pilot Projects; Population; Population Sciences; Positioning Attribute; Postdoctoral Fellow; Prevention; Prevention strategy; Qi; Research; Research Personnel; Research Proposals; Resources; Role; Scientist; Seeds; Sister; Sleep Apnea Syndromes; Translational Research; Translations; Underrepresented Minority; Underrepresented Populations; Universities; Work; base; cardiovascular disorder risk; career; clinical investigation; cognitive function; cost; cost effective; critical period; design; feasibility research; innovation; medical schools; member; mother nutrition; multidisciplinary; next generation; non-alcoholic fatty liver disease; novel; nutrition; obesity treatment; operation; practical application; preservation; programs; recruit; synergism; therapy development; tool; training opportunity; Address; Adult; Advertising; Age; Animal Model; Applications Grants; Area; Award; Back; Basic Science; Binding; Centers of Research Excellence; Childhood; Chronic Disease; Clinical; Clinical Sciences; Collaborations; Data; Development; Direct Costs; Discipline; Disease; Environment; Equipment; Faculty; Feasibility Studies; Felis catus; Fostering; Funding; Future; Goals; Grant; Health; Health Sciences; Human; Human Resources; Impairment; Incentives; Infant; Infrastructure; Institution; Intervention; Life Cycle Stages; Life Style Modification; Longevity; Louisiana; Malignant Neoplasms; Medical; Mentors; Mentorship; Metabolic; Metabolic syndrome; Methods; Minority; Minority Groups; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Nutritional Science; Nutritional status; Obesity; Phenotype; Physical Function; Pilot Projects; Population; Population Sciences; Positioning Attribute; Postdoctoral Fellow; Prevention; Prevention strategy; Qi; Research; Research Personnel; Research Proposals; Resources; Role; Scientist; Seeds; Sister; Sleep Apnea Syndromes; Translational Research; Translations; Underrepresented Minority; Underrepresented Populations; Universities; Work; base; cardiovascular disorder risk; career; clinical investigation; cognitive function; cost; cost effective; critical period; design; feasibility research; innovation; medical schools; member; mother nutrition; multidisciplinary; next generation; non-alcoholic fatty liver disease; novel; nutrition; obesity treatment; operation; practical application; preservation; programs; recruit; synergism; therapy development; tool; training opportunity

PROJECT SUMMARY/ABSTRACT (OVERALL PENNINGTON/LOUISIANA NORC) This is an application for a 5-year competitive renewal of the Pennington/Louisiana Nutrition Obesity Research Center (NORC). The role of the NORC is to promote, facilitate and enhance collaborative and multi-disciplinary interactions to foster new research ideas and programs in nutrition and obesity. In doing so, the NORC facilitates and enhances the translation of basic nutritional research findings into the clinical arena and ultimately into practical applications. Since its inception in 2005, our research base funding has steadily grown to >$44 million per year in direct costs and 146 members including 63 Regular Members (part of the research base funding), 70 Collaborating Members (collaborate with our regular members) and 13 Mentored Members (Early Stage Investigators working under the mentorship of NORC members). The Center provides a stable administrative infrastructure and exemplary facilities. NORC members have access to three state-of-the-art biomedical cores to conduct their research with the highest rigorous standards; a “Human Phenotyping Core”, a “Molecular Mechanism Core” and an “Animal Model and Phenotyping Core”. Moreover, our vibrant and successful Pilot & Feasibility Grant Program provides Early Career Investigators with seed funding to jump-start innovative research programs and generate the necessary preliminary data for larger grant applications. Finally, our NORC Enrichment Program provides outstanding training opportunities and mentoring activities to junior scientists which extends to nutrition and obesity researchers across the entire state of Louisiana. The central theme of our NORC is “Nutrition, Obesity and Metabolic Health through the Lifespan”. To impact the prevention and treatment of obesity and its metabolic complications across the lifespan (from maternal nutrition to older age physical/cognitive functionality) through better nutrition, lifestyle modifications, and medical treatments, we have developed three translational research teams. These Translational Research Teams will address big research questions from the basic science level, to clinical investigation and finally implementation to the population. In each of these teams, research focuses on the mechanisms involved in health and disease, the development of treatment interventions and the implementation of preventive strategies. After 15 years of operation, the Pennington/Louisiana NORC with unwavering institutional support has never been as well- positioned to advance the science of nutrition and obesity on so many fronts and to foster the next generation of leaders in this field.

项目摘要/摘要（整体Pennington/Louisiana Norc） 这是对Pennington/Louisiana Nutrition肥胖研究的5年竞争性更新的申请 中心（NORC）。 NORC的作用是促进，促进和增强协作和多学科 互动以培养营养和肥胖的新研究思想和计划。这样，NORC的最爱 并增强基本营养研究结果的转化为临床领域，并最终转化为 实际应用。自2005年成立以来，我们的研究基础资金已悄悄地增长到4400万美元 每年的直接费用和146名成员，其中包括63位常规成员（研究基础资金的一部分）， 70名合作成员（与我们的常规成员合作）和13位导师（早期阶段） 在NORC成员的心态下工作的调查人员）。该中心提供稳定的管理 基础设施和示例设施。 NORC成员可以使用三个最先进的生物医学核心 以最高严格的标准进行研究； “人类表型核”，“分子 机理核心和“动物模型和表型核心”。此外，我们的充满活力和成功 飞行员和可行性赠款计划为早期职业调查人员提供种子资金，以跳跃 创新的研究计划并为更大的赠款应用程序生成必要的初步数据。最后， 我们的NORC丰富计划为初级提供出色的培训机会和心理活动 扩展到整个路易斯安那州的营养和肥胖研究人员的科学家。中央 我们NOC的主题是“通过生命周期的营养，肥胖和代谢健康”。影响 预防和治疗肥胖症及其在整个生命周期的代谢并发症（来自Mater营养） 通过更好的营养，生活方式修改和医学 治疗方法，我们已经建立了三个翻译的研究团队。这些翻译研究团队将 从基础科学层面到临床调查并最终实施，解决了大型研究问题 对人口。在每个团队中，研究都集中在健康和疾病涉及的机制上， 治疗干预措施的发展和预防策略的实施。 15年后 行动，彭宁顿/路易斯安那州的诺克（Norc）拥有坚定不移的机构支持 定位于在许多方面推进营养和肥胖科学，并促进下一代 该领域的领导者。