Columbia University Skin Disease Resource-Based Center (epiCURE)

哥伦比亚大学皮肤病资源中心 (epiCURE)

• 批准号: 9087989
• 负责人: DAVID RINSEY BICKERS
• 金额: $ 80万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9087989
• 关键词: Academic Medical Centers; Address; Adopted; Algorithms; Area; Awareness; Basic Science; Biology; Biomedical Research; Charge; Clinic; Clinical; Clinical Research; Clinical effectiveness; Collaborations; Communities; Core Facility; Country; Cutaneous; Dermatology; Development; Disease; Disease model; Elements; Environment; Feasibility Studies; Fostering; Future; Goals; Immunity; Institute of Medicine (U.S.); Institution; International; Investigation; Mission; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nerve; New York; Pathologic; Patients; Phase; Pilot Projects; Pre-Clinical Model; Quality of life; Research; Research Personnel; Research Project Grants; Research Training; Resources; Scientist; Services; Skin; Staging; Stem cells; Strategic Planning; Structure; Training and Education; Translating; Translational Research; Universities; base; cellular imaging; clinical efficacy; community based participatory research; design; education research; fundamental research; improved; innovation; meetings; metropolitan; multidisciplinary; pre-clinical; pre-clinical research; precision medicine; programs; public health relevance; response; skin disorder; sound; success; translational medicine

 DESCRIPTION (provided by applicant): This application proposes the creation of a Skin Disease Resource-Based Core center at Columbia University (epiCURE). The epiCURE is designed to address critical roadblocks on the Continuum of Translational research as defined by the Institute of Medicine. The continuum defines three critical translational phases in biomedical research: basic science into pre-clinical efficacy into clinical effectiveness. The Cores of the epiCURE center have been strategically configured to address these critical phases in skin disease research, and provide a unique set of services and resources to facilitate advancement of the Research Community along the translational continuum pipeline that is driven by a Precision Medicine-based algorithm and is responsive to the NIAMS mission. The epiCURE Center, and the Institutional Commitment that accompanies it, can accomplish this goal by providing a uniquely effective service-based vehicle for investigator interactions that further education, training and research in cutaneous biology and skin disease. The configuration of the epiCURE represents a natural, logical progression built on the previous successes of our existing SDRC over the past 18 years, in bridging basic discoveries and translational research, and catalyzing their entry into the clinic. We have given very careful consideration to selecting the service and resource components of the epiCURE so that they bolster the existing research excellence at Columbia University and the broader Research Community, which is comprised of 37 investigators at Columbia University as well as 37 investigators at other 18 institutions in the New York metropolitan area and across the country. In addition to an Administrative Core and innovative Enrichment Program, the epiCURE is structured around three Service Cores that span a continuum of basic, pre-clinical and translational research: 1) Skin Stem Cell Imaging and Manipulation (SCIM); 2) Skin Immunity, Integrity and Disease Models (SIND); and 3) Translational and Precision Medicine Resources (TRAP). The overall goal of the epiCURE center is to break down barriers to translational research, and accelerate the progress of investigation in skin disease research to rapidly advance from basepairs to bedside.

 描述（由申请人提供）：本申请建议在哥伦比亚大学创建一个基于皮肤疾病资源的核心中心（epiCURE）。epiCURE 旨在解决医学研究所定义的连续转化研究的关键障碍。该连续体定义了生物医学研究的三个关键转化阶段：从基础科学到临床前疗效再到临床有效性 EpiCURE 中心的核心经过战略配置来解决这些关键问题。皮肤病研究的各个阶段，并提供一套独特的服务和资源，以促进研究社区沿着基于精准医学的算法驱动并响应 NIAMS 使命的连续转化管道的发展。随之而来的机构承诺可以通过为研究者互动提供独特有效的基于服务的工具来实现这一目标，从而进一步促进皮肤生物学和皮肤病的教育、培训和研究。epiCURE 的配置代表了自然、合乎逻辑的进展。建立在我们现有 SDRC 过去 18 年的成功基础上，在桥接基础发现和转化研究并促进其进入临床方面，我们非常仔细地考虑了 EpiCURE 的服务和资源组成部分，以便它们能够实现。加强哥伦比亚大学和更广泛的研究社区的现有研究成果，该社区由哥伦比亚大学的 37 名研究人员以及纽约大都会区和全国其他 18 个机构的 37 名研究人员组成。作为行政核心和创新丰富计划，epiCURE 围绕三个服务核心构建，涵盖一系列基础、临床前和转化研究：1) 皮肤干细胞成像和操作 (SCIM)；2) 皮肤免疫、完整性和疾病模型； (SIND)；3) 转化和精准医学资源 (TRAP)。epiCURE 中心的总体目标是打破转化研究的障碍，以及加快皮肤病研究进展，从基础对快速推进到临床。