CALIFORNIA TEACHERS STUDY

加州教师研究

• 批准号: 7432634
• 负责人: LESLIE BERNSTEIN
• 金额: $ 248.27万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-25 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7432634
• 关键词: Accounting; Address; Administrator; Age; Alcohol consumption; Alcohol dehydrogenase; Alcohols; Anabolism; Benefits and Risks; Beverages; Blood; Blood specimen; Breast; Breast Cancer Prevention; California; Cancer Etiology; Cancer Patient; Candidate Disease Gene; Cardiovascular Diseases; Categories; Cause of Death; Cessation of life; Characteristics; Cohort Studies; Collection; Colon Carcinoma; Colorectal Cancer; Condition; Cytochrome P450; DNA; Data; Data Collection; Dementia; Diabetes Mellitus; Dietary intake; Disease; Drug Formulations; Ductal; Educational Background; Endometrial; Endometrial Carcinoma; Energy Intake; Epidemiology; Equation; Estrogen Receptors; Estrogen Therapy; Estrogens; Etiology; Event; Fracture; Funding; GSTM1 gene; GSTP1 gene; GSTT1 gene; GSTT1 protein; Genes; Genetic; Genotype; Glutathione S-Transferase; Haplotypes; Histology; Incidence; Individual; Invasive; Isothiocyanates; Life Style; Low Prevalence; Mails; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Menopausal Status; Metabolism; Methods; Modification; Myocardial Ischemia; Newsletter; Outcome; Ovarian; Ovarian Steroid Hormone; Participant; Pathway interactions; Pattern; Personal Satisfaction; Physical activity; Positioning Attribute; Prevention; Process; Progesterone; Progesterone Receptor Status; Progesterone Receptors; Progestins; Prospective Studies; Purpose; Questionnaires; Race; Rate; Recontacts; Reporting; Research; Research Infrastructure; Research Personnel; Retirement; Risk; Sampling; Schedule; School Teachers; Series; Smoking; Staging; Stroke; Suicide; System; Taxes; Testing; Tobacco; Transactivation; Transferase Gene; Update; Variant; Woman; Women' s Health; anticancer research; base; cancer risk; cohort; data management; design; energy balance; experience; follow-up; glutathione S-transferase M1; glutathione S-transferase pi; hormone therapy; innovation; interest; malignant breast neoplasm; melanoma; member; mortality; novel; programs; size; teacher; therapy duration; time use; tumor

DESCRIPTION (provided by applicant): The California Teachers Study (CTS) is a prospective study of 133,479 California teachers initiated in 1995 by a consortium of California research centers with expertise in epidemiology and cancer etiology. The study was designed to understand better the etiology and prevention of breast cancer and of other major women's health problems; as such, the initiation of the cohort was supported by California tobacco taxes targeted to breast cancer research. Members of the cohort were identified through their participation in the California State Teachers Retirement System (STRS) to which all public school teachers and administrators must belong. An early observation from the CTS cohort is the extraordinarily high breast cancer rates experienced by California teachers. Incidence rates for invasive breast cancer are approximately 51% higher than those expected among women of comparable age and race in California. Moreover we have reported that the CTS cohort has very high rates of endometrial and ovarian cancers as well as melanoma. Among the strengths of the CTS cohort are its size and the detailed exposure and lifestyle assessment made at baseline and through subsequent contacts with cohort members. We were able to gather more detailed data from participants in the CTS than are typically collected from members of other large healthy cohorts, primarily because of the uniformly high education levels of the CTS membership. The scientific specific aims for the next five years of the CTS are focused around a small series of detailed exposure characteristics, including various patterns of hormone therapy (HT) use, dietary intake of isothiocyanates, alcohol consumption, and physical activity/energy balance. Because of the size and excellent follow-up of the CTS, we will expand the cancer outcomes of interest for selected hypotheses to include not just breast cancer as in the previous funding period, but also colorectal cancer, endometrial cancer, ovarian cancer, and lung cancer. We also propose to target 2,500 incident breast cancer patients and an equal sample of healthy CTS participants for blood collection and DNA extraction to evaluate a series of hypotheses regarding genetically-based modification of or interactions with certain exposure/breast cancer relationships. Finally, we propose to maintain the sophisticated infrastructure already in place, to continue detailed follow-up and periodic recontact of CTS members, and to process new data and continue analysis of existing data on CTS participants.

描述（由申请人提供）：加州教师研究 (CTS) 是一项针对 133,479 名加州教师的前瞻性研究，由具有流行病学和癌症病因学专业知识的加州研究中心组成的联盟于 1995 年发起。该研究旨在更好地了解乳腺癌和其他主要女性健康问题的病因和预防；因此，该队列的启动得到了加州针对乳腺癌研究的烟草税的支持。该群体的成员是通过参与加州教师退休系统（STRS）而确定的，所有公立学校教师和管理人员都必须加入该系统。 CTS 队列的一项早期观察结果是，加州教师的乳腺癌发病率极高。加州同龄和种族女性的浸润性乳腺癌发病率比预期高出约 51%。此外，我们还报告称，CTS 队列的子宫内膜癌、卵巢癌以及黑色素瘤发病率非常高。 CTS 队列的优势在于其规模以及在基线时以及通过随后与队列成员的接触进行的详细暴露和生活方式评估。我们能够从 CTS 参与者那里收集到比通常从其他大型健康队列成员收集的数据更详细的数据，这主要是因为 CTS 成员的教育水平一致较高。 CTS 未来五年的科学具体目标集中于一系列详细的暴露特征，包括激素治疗 (HT) 使用的各种模式、异硫氰酸盐的饮食摄入量、酒精消耗和体力活动/能量平衡。由于 CTS 的规模和出色的随访，我们将扩大选定假设的感兴趣的癌症结果，不仅包括上一个资助期间的乳腺癌，还包括结直肠癌、子宫内膜癌、卵巢癌和肺癌癌症。我们还建议针对 2,500 名乳腺癌患者和健康 CTS 参与者的同等样本进行血液采集和 DNA 提取，以评估一系列关于基于基因的修改或与某些暴露/乳腺癌关系相互作用的假设。最后，我们建议维持现有的复杂基础设施，继续对 CTS 成员进行详细的跟进和定期重新联系，并处理新数据并继续分析 CTS 参与者的现有数据。