Leveraging CLEERE axial length data to improve myopia treatment

利用 CLEERE 眼轴长度数据改善近视治疗

• 批准号: 10725732
• 负责人: LISA A Jordan
• 金额: $ 43.31万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10725732
• 关键词: Address; Affect; Age; Benchmarking; Biological; Biometry; Child; Child Care; Childhood; Clinical; Clinical Trials; Communication; Cornea; Data; Data Analyses; Data Set; Development; Early treatment; Ethnic Origin; Ethnic Population; Evaluation; Eye; Eye Development; Future; Goals; Growth; Individual; Infant; Length; Longitudinal cohort; Modeling; Morbidity - disease rate; Myopia; Outcome Measure; Parents; Participant; Prevalence; Preventive treatment; Probability; Race; Radial; Refractive Errors; Reporting; Research; Research Project Grants; Risk; Risk Marker; Severities; Sports; Techniques; Testing; Time; Treatment Effectiveness; Vision; Vision research; Visual impairment; Work; clinical effect; design; disorder of macula of retina; effectiveness evaluation; expectation; improved; predictive modeling; prevent; primary outcome; protective effect; racial population; sex; tool

Project Summary/Abstract The dual objectives of myopia research are to prevent myopia onset and, barring that, to reduce myopia progression. The field currently has no way to communicate the effectiveness of the treatments being designed to slow myopia progression other than citing average effects from clinical trials. Clinicians want to be able to demonstrate to children and their parents the impact that a treatment is having on an individual child’s myopia. To do this, percentiles of the expected growth of the eye are necessary. Additionally, the goal of preventing or delaying onset requires being able to predict who will become myopic. Models currently use basic information from one time point to make a simple prediction of more likely than not to develop myopia. Clinicians need an improved model that can assign specific probabilities to individual children in order to properly identify those whose risk of future myopia justifies starting a preventive treatment. The CLEERE Study has the largest longitudinal cohort of ocular development across a variety of race/ethnic groups that will aid in answering these questions. CLEERE provided one of the first reports on the protective effect of time outdoors, but its effects on axial length have yet to be described. Using these data to accomplish the following aims will improve the care of these children. Specific Aim 1: To analyze axial length data and address critical clinical questions in myopia control, namely whom to treat and whether treatment is beneficial. Specific Aim 2: To determine the effect of time spent outdoors/sports activity on axial elongation before and after myopia onset. Specific Aim 3: To improve predictive models by determining whether the trajectory of change in axial length or other ocular components in non-myopic children is a better predictor of the risk of onset of myopia than spherical equivalent refractive error at a single point in time. This NEI Research Grant for Vision-related Secondary Data Analysis (PAR 22-141) will incorporate statistical techniques not routinely employed in vision research to leverage this large existing dataset to more fully explore how to give clinicians the tools they need to effectively treat and manage children’s refractive error.

项目摘要/摘要 近视研究的双重对象是防止近视发作并禁止这一点，以减少 近视进展。该领域目前无法传达 旨在减慢近视进展的治疗，而不是引用平均影响 临床试验。临床医生希望能够向孩子及其父母展示影响 一种治疗正在对个别孩子的近视进行。为此，预期的百分位数 眼睛的生长是必要的。此外，预防或延迟发作的目标需要 能够预测谁将变成近视。模型当前使用一个基本信息 时间点可以简单地预测更有可能发展近视。临床医生 需要一个改进的模型，可以为单个孩子分配特定的可能性才能 正确地确定那些开始预防治疗的未来近视理由的风险。 Cleer研究具有各种各样的眼部发育纵向队列 种族/种族将有助于回答这些问题。克莱尔提供了第一个 有关户外时间受保护作用的报告，但其对轴向长度的影响尚未 描述。使用这些数据完成以下目标将改善对这些目标的护理 孩子们。 特定目的1：分析轴向长度数据并解决关键的临床问题 近视控制，即治疗谁以及治疗是否有益。 特定目标2：确定所花费的时间在户外/运动活动对轴向的影响 近视发作之前和之后的伸长。 特定目的3：通过确定是否是否轨迹来改善预测模型 轴向长度的变化或非杂型儿童中的其他眼部成分更好 预测近视发作风险而不是球形等效折射率 单点。 这项与视觉相关的二级数据分析（Par 22-141）的NEI研究赠款将 合并的统计技术不常规地用于视觉研究中，以利用这一大型 现有数据集，以更充分的探索如何为临床医生提供有效的工具 治疗和管理儿童的折射率。