Engineering Structural Tissues for Clinical Medicine

临床医学工程结构组织

• 批准号: 7076817
• 负责人: Alan Russell
• 金额: $ 23.12万
• 依托单位: PITTSBURGH TISSUE ENGINEERING INITIATIVE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7076817
• 关键词: Engineering; Structural; Tissues; Clinical; Medicine

DESCRIPTION (provided by applicant): The Pittsburgh Tissue Engineering Initiative (PTEI) is the applicant organization for this Institutional NRSA to support postdoctoral fellowship training in musculoskeletal tissue engineering (TE) for clinical applications in medicine and surgery. PTEI is a not-for-profit organization whose mission is to foster TE research and education regionally, nationally, and internationally. The major regional academic institutions (Allegheny General Hospital, Carnegie Mellon University, Children's Hospital of Pittsburgh, Duquesne University, University of Pittsburgh, and University of Pittsburgh Medical Center) are members of PTEI and provide the venues for TE academic research and development. PTEI supports these organizations through seed research grants and educational programs, including its Postdoctoral Fellowship Program. As well, PTEI fosters university-academic relationships with the burgeoning TE biotechnology commercial enterprise. The PTEI Postdoctoral Fellowship Program began in January 2000 and is special in that each fellow is assigned a primary and a secondary mentor, chosen from the member institutions and based on the correspondence between the mentors' expertise and the fellow's prior training and desired focus within TE. The two mentors may be in the same or different institutions. The mentors include M.D.s, D.M.D.s, D.D.S.s, Ph.D.s, and those with dual degrees; emphasis is on clinician-basic scientist pairing of mentors. The supporting facilities and didactic opportunities thus span the major academic institutions in Pittsburgh. The Fellowship is two years long, with an option for a third year. Each fellow spends 2/3-3/4 of the two-year fellowship in the primary mentor's laboratories and the rest with the secondary mentor; these assignments may be consecutive or concurrent. Additional ad hoc experiences are arranged as needed. An introductory course in starting a biotechnology company, taught at Carnegie Mellon University, and formal instruction in the responsible conduct of research are required didactic activities. The primary mentor's institution manages the administrative aspects of the fellowship, and PTEI contractually provides monetary support to that institution. The first two post-doctoral fellows began in early 2000, and the second two began in early 2001. Advertising for the third round will begin in February 2002. A local PTEI Executive Committee provides administrative oversight for the Fellowship Program, and a larger Scientific Advisory Committee is being established. Initial fellowship funding has been provided by both local and federal funding, but continuation and expansion of the program depends on wider extramural support. Musculoskeletal TE is the current major strength of PTEI's member institutions; this application, therefore, is focused on this area of TE and its clinical application.

描述（由申请人提供）：匹兹堡组织工程倡议 (PTEI) 是该机构 NRSA 的申请组织，旨在支持肌肉骨骼组织工程 (TE) 的博士后奖学金培训，以用于医学和外科临床应用。 PTEI 是一个非营利组织，其使命是促进地区、国家和国际范围内的 TE 研究和教育。主要地区学术机构（阿勒格尼总医院、卡内基梅隆大学、匹兹堡儿童医院、杜肯大学、匹兹堡大学和匹兹堡大学医学中心）都是 PTEI 的成员，并为 TE 学术研究和发展提供场所。 PTEI 通过种子研究补助金和教育计划（包括其博士后奖学金计划）来支持这些组织。此外，PTEI 还与新兴的 TE 生物技术商业企业建立大学学术关系。 PTEI 博士后奖学金计划于 2000 年 1 月开始，其特殊之处在于，每个研究员都被分配了一名主要导师和一名二级导师，这些导师是从成员机构中选出的，并根据导师的专业知识与研究员之前的培训以及 TE 内的期望关注点之间的对应关系进行选择。两位导师可以在同一机构，也可以在不同机构。导师包括M.D.、D.M.D.、D.D.S.、Ph.D.、双学位者；重点是临床医生与基础科学家的导师配对。因此，配套设施和教学机会遍布匹兹堡的主要学术机构。该奖学金为期两年，可以选择第三年。每个研究员两年的研究金中有 2/3-3/4 在初级导师的实验室度过，其余时间在二级导师的实验室度过；这些分配可以是连续的或同时的。根据需要安排额外的临时体验。卡内基梅隆大学教授的关于创办生物技术公司的入门课程以及负责任的研究行为的正式指导都是教学活动所必需的。主要导师的机构负责管理奖学金的行政事务，PTEI 按合同向该机构提供资金支持。前两名博士后研究员于 2000 年初开始，后两名于 2001 年初开始。第三轮的广告将于 2002 年 2 月开始。当地的 PTEI 执行委员会为奖学金计划提供行政监督，并提供更大的科学咨询委员会正在成立。最初的奖学金资金由地方和联邦资金提供，但该计划的继续和扩大取决于更广泛的外部支持。肌肉骨骼TE是目前PTEI成员机构的主要优势；因此，本应用重点关注 TE 领域及其临床应用。

项目成果

Prostaglandin E2 differentially regulates contraction and structural reorganization of anchored collagen gels by human adult and fetal dermal fibroblasts.

• DOI: 10.1111/j.1524-475x.2008.00445.x
• 发表时间: 2009-01
• 期刊: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
• 作者: Parekh A;Sandulache VC;Singh T;Cetin S;Sacks MS;Dohar JE;Hebda PA
• 通讯作者: Hebda PA

Three-dimensional imaging properties of rotation-free square and hexagonal micro-CT systems.

无旋转方形和六边形微型 CT 系统的三维成像特性。

• DOI: 10.1109/tmi.2009.2039799
• 发表时间: 2010
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6
• 作者: Quan,EnzhuoMichelle;Lalush,DavidS
• 通讯作者: Lalush,DavidS

Repair of the tympanic membrane with urinary bladder matrix.

• DOI: 10.1002/lary.20233
• 发表时间: 2009-06
• 期刊: LARYNGOSCOPE
• 影响因子: 2.6
• 作者: Parekh, Aron;Mantle, Belinda;Banks, Juliane;Swarts, J. Douglas;Badylak, Stephen F.;Dohar, Joseph E.;Hebda, Patricia A.
• 通讯作者: Hebda, Patricia A.