Pilot Projects and Trans-Network Activities Core

试点项目和跨网络活动核心

基本信息

批准号：
9446709
负责人：
John F. Dipersio
金额：
$ 25.44万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9446709
关键词：
Advisory Committees Advocate Applied Research Award Basic Science Biological Markers Cancer Center Cancer Therapy Evaluation Program Clinical Trials Conflict of Interest Development Early Therapeutic-Clinical Trials Network Electronic Mail Fostering Funding Goals Grant Institution Leadership Life Malignant Neoplasms Mentors Mission Modeling Newsletter Patients Phase Pilot Projects Pre-Clinical Model Process Recommendation Recruitment Activity Reproducibility Request for Applications Research Research Methodology Research Personnel Research Project Grants Review Committee Scientist Solid Neoplasm Testing Translating Translational Research Underrepresented Minority Universities Validation Washington Woman Work anticancer research base human disease innovation member minority investigator patient subsets pre-clinical programs research and development

项目摘要

Project Summary/Abstract: Pilot Projects and Trans-Network Activities Core The goal of the Pilot Projects and Trans-Network Activities Core is to support the development of research projects using PDX models that will advance the mission of the PDTC and PDXNet. The core will help to foster collaborative, translational research using well-characterized PDX models that recapitulate human disease. Projects will expand the scope of translational research and increase the number of investigators committed to testing CTEP agents using PDX models for developing the preclinical justification needed for Phase I/II clinical trials. Requests for Application (RFA) for two awards of $50,000 dollars a year will be solicited. One within the PDTC and one that is open to non-PDXNet members. The goal of these projects will be to support the translational goals of the PDTC to advance translational research through the use of PDX models or, research methods to enhance experimental validation and reproducibility across PDTCs. Requests for Applications (RFA) for PDX based projects will be requested annually. All developmental research project applications will be reviewed by Pilot Research Program Advisory Committee consisting of scientists (representing basic and applied science) with expertise in solid tumor cancers, a biostatistician, a patient advocate, and ad hoc members, as necessary (special expertise, no conflict of interest). This committee will make recommendations to the PDTC Leadership Committee, which will make final funding decisions. Relevance The work proposed will lead to increased utilization of PDXs as models of human disease that can be used as the preclinical justification for testing CTEP agents in patient sub-populations based on biomarkers.

项目摘要/摘要：试点项目和跨网络活动核心试点项目和跨网络活动核心的目标是支持研究的发展使用 PDX 模型的项目将推进 PDTC 和 PDXNet 的使命。核心将有助于培育使用表征人类疾病的特征良好的 PDX 模型进行协作转化研究。项目将扩大转化研究的范围并增加致力于研究的研究人员数量使用 PDX 模型测试 CTEP 药物，以开发 I/II 期临床所需的临床前论证试验。将征集两项每年 50,000 美元奖励的申请请求 (RFA)。内一 PDTC 以及向非 PDXNet 成员开放的一个。这些项目的目标是支持 PDTC 的转化目标是通过使用 PDX 模型或研究来推进转化研究增强 PDTC 实验验证和重现性的方法。申请请求基于 PDX 的项目每年都会请求 (RFA)。所有开发研究项目申请将由科学家组成的试点研究计划咨询委员会（代表基础和应用科学），具有实体瘤癌症方面的专业知识、生物统计学家、患者倡导者和特设人员必要时的成员（特殊专业知识，无利益冲突）。该委员会将提出建议提交给 PDTC 领导委员会，该委员会将做出最终的资助决定。关联拟议的工作将导致更多地利用 PDX 作为人类疾病模型，可用作基于生物标志物在患者亚群中测试 CTEP 药物的临床前理由。