Subtypes of Schizophrenia: ERPs During Memory Processing

精神分裂症的亚型：记忆处理过程中的 ERP

• 批准号: 7155495
• 负责人: GERARD E BRUDER
• 金额: $ 35.28万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155495
• 关键词: Adult; Appendix; Attention; Auditory Perception; Behavioral; Biologic Characteristic; Biological; Brain; Cerebrum; Characteristics; Clinical; Cognitive; Cognitive deficits; Data; Episodic memory; Event-Related Potentials; Face; Functional disorder; Genetic Predisposition to Disease; Gur; Handedness; Heterogeneity; Hippocampal Formation; Learning; Left; Measures; Medial; Memory; Memory impairment; Mitochondrial Carnitine Palmitoyltransferase Pathway; Modeling; Neurocognitive; Neuropsychological Tests; Numbers; Patients; Perception; Performance; Pharmaceutical Preparations; Phase; Phenotype; Positioning Attribute; Problem Solving; Process; Relative (related person); Research Personnel; Resolution; Retrieval; Schizophrenia; Screening procedure; Series; Short-Term Memory; Site; Specificity; Staging; Standards of Weights and Measures; Stimulus; Subgroup; Symptoms; Testing; Validation; atypical antipsychotic; behavior measurement; episodic memory impairment; executive function; face perception; memory process; memory recognition; millisecond; neurocognitive test; programs; response

DESCRIPTION (provided by applicant): Working memory and episodic memory impairments are present in patients with schizophrenia and their relatives, suggesting that it may represent a "cognitive phenotype" of schizophrenia. This project proposes to use brain event-related potentials (ERPs) and behavioral measures to study both working memory and recognition memory for words and faces in patients with schizophrenia. The fine temporal resolution of ERPs will aid in determining the specific stages of processing (encoding, storage and retrieval) associated with abnormalities on these memory tests. Preliminary ERP findings during a word serial position test suggest that a left-frontal slow wave associated with short-term storage of words is reduced in schizophrenia patients, and abnormalities during a word recognition memory test are evident as early as 100 to 200 milliseconds after stimulus onset. Recording ERPs to both words and faces will provide additional information concerning material-specificity of abnormalities of memory function and cerebral laterality in schizophrenia. ERPs of 60 unmedicated schizophrenic patients, 60 patients receiving an atypical antipsychotic, and 60 healthy controls will be recorded during serial position tests and recognition memory tests with word and face stimuli. Patients and controls will also be tested on standard neurocognitive tests of attention (CPT), learning and memory (WMS-R), and problem solving (WCST). Unmedicated patients, medicated patients and healthy controls will be compared to determine whether differences in their performance and brain ERPs on these tests are related to medication status. In addition, ERP and behavioral data for patient subgroups and controls will be compared so as to contribute toward the identification and validation of "cognitive subtypes" with more homogeneous clinical and biological characteristics. A series of studies has identified a subgroup of patients who perform as well as healthy adults on a screening test of attention and tonal perception, but who have a selective deficit in verbal memory (discriminators, Dsz), while a second subgroup of patients, who perform poorly on the screening test, show evidence of a generalized cognitive deficit (non-discriminators, NDsz). The project aims to further validate these subgroups by testing hypothesized differences in their material-specific memory function, ERP abnormalities during different phases of memory processing, deficits on standard neurocognitive tests, and symptom features.

描述（由申请人提供）：精神分裂症及其亲戚患者存在工作记忆和情节记忆障碍，这表明它可能代表了精神分裂症的“认知表型”。该项目建议使用与大脑事件相关的电位（ERP）和行为措施研究精神分裂症患者的单词和面孔的工作记忆和识别记忆。 ERP的精细时间分辨率将有助于确定与这些内存测试中异常相关的处理（编码，存储和检索）的特定阶段。在单词串行位置测试中的初步ERP发现表明，精神分裂症患者中与单词短期存储相关的左额慢波会减少，并且在刺激发作后，单词识别记忆测试期间的异常早在100至200毫秒内就显而易见。将ERP记录到单词和脸上将提供有关记忆功能异常和精神分裂症大脑侧向的材料特异性的其他信息。在串行位置测试中，将记录60名未药物精神分裂症患者的ERP，60名接受非典型抗精神病药的患者以及60例健康对照的ERP，并记录使用单词和面部刺激的识别记忆测试。患者和对照组还将在标准的注意力（CPT），学习和记忆（WMS-R）和解决问题（WCST）上进行测试。将比较未药物的患者，药物患者和健康对照组，以确定其性能差异和这些测试的大脑ERP是否与药物状态有关。此外，将比较患者亚组和对照组的ERP和行为数据，以促进具有更均匀的临床和生物学特征的“认知亚型”的识别和验证。一系列研究已经确定了在注意力和色调感知的筛查测试中表现和健康成年人的子组，但他们在言语记忆中有选择性赤字（鉴别剂，DSZ），而第二个子组在筛查测试中表现较差，在筛查测试中表现较差，证明了一般性认知性不足的证据。该项目旨在通过测试其材料特异性记忆功能的假设差异，内存处理不同阶段的ERP异常，对标准神经认知测试的缺陷以及症状特征的缺陷来进一步验证这些亚组。