BRAIN ERPS AND COGNITIVE DEMAND IN SCHIZOPHRENIA

精神分裂症患者的大脑 ERPS 和认知需求

• 批准号: 2883371
• 负责人: GERARD E BRUDER
• 金额: $ 23.18万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2883371
• 关键词: audiometry; auditory discrimination; auditory stimulus; behavior test; brain electrical activity; cerebral dominance; clinical research; clozapine; cognition; electroencephalography; evoked potentials; family genetics; human subject; mental disorder chemotherapy; neural information processing; neuropsychological tests; risperidone; schizophrenia; sound perception; space perception; temporal lobe /cortex; visual perception; visual stimulus; audiometry; auditory discrimination; auditory stimulus; behavior test; brain electrical activity; cerebral dominance; clinical research; clozapine; cognition; electroencephalography; evoked potentials; family genetics; human subject; mental disorder chemotherapy; neural information processing; neuropsychological tests; risperidone; schizophrenia; sound perception; space perception; temporal lobe /cortex; visual perception; visual stimulus

DESCRIPTION (Adapted from applicant's abstract): Schizophrenic patients have shown a reduction in amplitude of the P3 brain ERP to tones, which was maximal over left temporal lobe sites. In the initial project period, the investigator replicated this finding in a dichotic complex tone task and found reduced N2 amplitude and asymmetry in schizophrenic patients in a dichotic syllable task. This suggests that left hemisphere dysfunction in schizophrenia for verbal processing occurs as early as 200 ms after stimulus onset. N2 abnormalities in schizophrenic patients were present in both auditory and visual tasks, whereas P3 abnormalities appear to be modality specific. The investigator proposes to conduct four studies to determine the task and patient characteristics necessary for producing these ERP abnormalities and to further resolve their neurophysiologic mechanisms. Study 1 will record ERPs in a large sample of schizophrenic patients (n=120) and normal controls (n=40) on verbal and nonverbal binaural oddball tasks, and will assess the influence of response mode (silent counting, right hand or left hand). These large samples will enable the investigator to examine the relation of ERP abnormalities in schizophrenia to symptom features, outcome of treatment with neuroleptics, familial history of schizophrenia, and neuroimaging measures. Study 2 will develop and apply new verbal and nonverbal tasks that incorporate advantages of dichotic listening procedures, but utilize a simple oddball paradigm. Study 3 compares ERPs of schizophrenic patients and controls in auditory and visual continuous word recognition tasks, which are thought to reflect left medial temporal lobe function. Study 4 continues the investigator's study of visuospatial processing in schizophrenia using a revised paradigm designed to disentangle effects of selective attention and later cognitive processing. Patients will be tested while off medication and again after six weeks of treatment with haloperidol or an atypical neuroleptic (clozapine or risperidone). A more long range clinical goal is to contribute toward the development of tests that could predict response to treatment with conventional or atypical neuroleptic medications for schizophrenia.

描述（改编自申请人的摘要）：精神分裂症患者 显示P3脑ERP振幅降低到音调，这是 最大的左颞叶位点。 在最初的项目期间， 研究人员在二分法复杂的语调任务中复制了这一发现， 发现精神分裂症患者的N2振幅降低和不对称性 Dichotic音节任务。 这表明在 刺激后200 ms的精神分裂症最早发生在200 ms 发作。 精神分裂症患者的N2异常均存在 听觉和视觉任务，而P3异常似乎是方式 具体的。 研究人员建议进行四项研究以确定 生产这些ERP所需的任务和患者特征 异常并进一步解决其神经生理机制。 研究1将记录大量精神分裂症患者样本中的ERP（n = 120） 以及口头和非语言双耳奇数球的正常对照（n = 40）， 并将评估响应模式的影响（无声计数，右手 或左手）。 这些大样本将使研究人员能够检查 精神分裂症中ERP异常与症状特征的关系， 神经疗法治疗的结果，精神分裂症的家族史， 和神经影像措施。 研究2将开发并应用新的口头和 非语言任务结合了Dichotic听力的优势 程序，但使用一个简单的奇数范式。 研究3比较ERP 精神分裂症患者和听觉和视觉连续单词的对照 识别任务，被认为反映了左侧颞叶 功能。 研究4继续研究者对视觉空间的研究 使用旨在解散的修订范式在精神分裂症中处理 选择性关注和后来的认知处理的影响。 患者 将在服药时进行测试，并在治疗六周后再次进行测试 与氟哌啶醇或非典型神经疗法（氯氮平或利培酮）。 一个 更长远的临床目标是为发展 可以预测常规或非典型治疗的反应的测试 精神分裂症的神经摄影药。