2018 Myelin Gordon Research Conference and Gordon Research Seminar

2018年髓磷脂戈登研究会议暨戈登研究研讨会

• 批准号: 9471150
• 负责人: Patrizia Casaccia
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9471150
• 关键词: Academia; Address; Adolescence; Adolescent; Adult; Affect; Age; Aging; American; Area; Attention; Biologic Development; Biology; Biotechnology; Brain; Brain Neoplasms; Cell Therapy; Cells; Central Nervous System Diseases; Cerebral Palsy; Child; Childhood; Clinical Investigator; Clinical Trials; Collaborations; Consensus; Dementia; Demyelinating Diseases; Deterioration; Development; Disabled Persons; Disease; Drug Industry; Elements; Emotional; Equilibrium; Europe; Evolution; Female; Funding; Future; Gender; Genes; Genetic; Glioma; Goals; Hereditary Disease; Human; Impaired cognition; Industry; Infant; Life Cycle Stages; Medicine; Mental disorders; Mentors; Molecular; Multiple Sclerosis; Myelin; Myelin Sheath; Neural Conduction; Oral; Outcome Measure; Participant; Pathogenicity; Pathologic; Pathology; Peripheral; Peripheral Nervous System; Peripheral Nervous System Diseases; Physiological; Physiology; Positioning Attribute; Postdoctoral Fellow; Production; Research; Research Personnel; Scientist; Senile dementia; Stratification; Stroke; Structure; Technology; Therapeutic; Time; Training; Transcriptional Regulation; Travel; Underrepresented Groups; Woman; age related; base; career; cost; dysmyelination; epigenetic regulation; fetal; functional restoration; graduate student; human disease; improved; innovation; interest; male; meetings; myelination; neurotransmission; new technology; next generation; novel; oligodendrocyte precursor; oligodendrocyte progenitor; planetary Atmosphere; posters; pre-clinical; prevent; programs; racial and ethnic; racial minority; regenerative; repaired; response to injury; screening; small molecule; social; success; symposium; therapeutic effectiveness; white matter

Project Summary This application is to request support for the 2018 Gordon Research Seminars (GRS; March 17, 18) and Conference (GRC, March 18-23) on Myelin to be held in Ventura, CA, USA. These meetings bring together researchers and trainees at the cutting edge of myelin development, physiology, pathology and treatment. This meeting uniquely focuses on central and peripheral myelin and is timely given growing interest in myelin biology and human disease and major advances since the last meeting in Europe in 2016. These advances include: developmental origins of oligodendrocyte precursors in the human fetal brain; genetic, epigenetic and transcriptional regulation of myelin production; an enhanced understanding of neuronal signals triggering myelination; new technologies to study myelin; the definition of myelination changes during human adolescence and its relevance in psychiatric disorders; mechanisms of age-dependent deterioration of myelin in dementia and stroke; progress in treating multiple sclerosis, as well as regenerative strategies to restore myelin. These and other advances position the field to go beyond the molecular, cellular and structural studies covered in previous meetings to address key research gaps in our understanding of myelin function at various key developmental stages, how these manifest as human disease, and the development of biologic, small molecule, gene and cell-based therapeutic approaches that will comprise the “therapies of the future.” The scientific program of the 14th GRC “Myelin Through the Ages” covers evolution and functions of myelin in the child, adolescent and adult, as well as diseases affecting myelin formation and integrity at these stages . The meeting will bring together basic and clinical investigators from academia and industry—almost a quarter of which have never spoken at a Myelin GRC before. We included an equal proportion of senior leaders and trainees/early career scientists and we have prioritized diversity and gender balance among the roster of speakers. All participants will contribute an oral or poster presentation, which serve as key elements to promote productive interactions amongst participants. These and other GRC activities will stimulate and accelerate progress in the field of myelin biology and medicine. The 2018 format will begin with the “Myelin GRS” building on the exceptional success of preceding meetings (2012-16). The GRS will provide a privileged venue for young investigators to interact, present their most current research and develop collaborations, as well as informal social activities. We expect more than 60 graduate students and postdoctoral fellows to attend the GRS and the GRC. We request funds to support travel and registration costs for invited PIs and trainees.

项目概要 此申请旨在请求对 2018 年戈登研究研讨会（GRS；2018 年 3 月 17 日）的支持，以及 髓磷脂会议（GRC，3 月 18 日至 23 日）将在美国加利福尼亚州文图拉举行。 处于髓磷脂发育、生理学、病理学和治疗前沿的研究人员和学员。 会议特别关注中枢和外周髓磷脂，鉴于人们对髓磷脂的兴趣日益浓厚，会议恰逢其时 生物学和人类疾病以及自 2016 年欧洲上次会议以来的重大进展。 包括：人类胎儿大脑中少突胶质细胞前体的发育起源； 髓磷脂生成的转录调控；增强对神经信号触发的理解； 髓鞘形成；研究髓鞘质变化的新技术； 青春期及其与精神疾病的相关性；年龄依赖性髓磷脂退化的机制 痴呆症和中风的治疗进展以及恢复的再生策略 这些和其他进展使该领域超越了分子、细胞和结构研究。 在之前的会议中讨论过，以解决我们对不同领域的髓磷脂功能理解中的关键研究差距 关键的发育阶段，这些阶段如何表现为人类疾病，以及生物、小型药物的发展 基于分子、基因和细胞的治疗方法将构成“未来的疗法”。 第14届GRC“髓磷脂穿越时代”的科​​学计划涵盖了髓磷脂在人体中的进化和功能 儿童、青少年和成人，以及影响这些阶段髓磷脂形成和完整性的疾病。 会议将汇集来自学术界和工业界的基础和临床研究人员——近四分之一 我们以前从未在髓磷脂集选区发表过讲话，其中包括同等比例的高级领导人和 受训者/早期职业科学家，我们优先考虑名单中的多样性和性别平衡 所有人都将进行口头或海报演示，这是演讲的关键要素。 这些活动和其他 GRC 活动将促进和促进参与者之间的富有成效的互动。 加速髓磷脂生物学和医学领域的进展 2018年的格式将从“髓磷脂”开始。 GRS”以之前会议（2012-16 年）取得的巨大成功为基础，GRS 将提供特权。 年轻研究人员互动、展示最新研究和发展合作的场所， 我们预计将有 60 多名研究生和博士后参加。 我们请求资金来支持受邀 PI 和学员的差旅费和注册费。