Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease

慢性鼻窦炎病理生理学和疾病机制的指导

基本信息

批准号：
10723793
负责人：
Justin H Turner
金额：
$ 11.6万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-12 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10723793
关键词：
Academic Medical Centers Adult Affect Airway Disease Bacteria Biological Markers Biological Response Modifier Therapy Biological Specimen Banks Career Choice Caring Cells Characteristics Clinical Clinical Research Cohort Studies Collection Data Development Diagnosis Disease Educational Status Elderly Enrollment Environmental Risk Factor Extramural Activities Faculty Functional disorder Funding Goals Head and Neck Surgery Healthcare Heterogeneity IL4 gene Immune Immunologics Inflammation Inflammation Mediators Inflammatory Institution Interferons Interleukin-13 Interleukin-5 Interleukin-6 Intervention Knowledge Link Measurement Mediator Medical Students Mentors Mentorship Midcareer Investigator Award in Patient-Oriented Research Mucous body substance Natural Immunity Nature Operative Surgical Procedures Otolaryngology Outcome Measure Paranasal Sinus Diseases Pathogenesis Pathway interactions Patient Outcomes Assessments Patient-Focused Outcomes Patients Pattern Physicians Population Postdoctoral Fellow Prevalence Productivity Publications Quality of life Recording of previous events Research Research Personnel Research Project Grants Resources Sampling Scientific Advances and Accomplishments Scientist Seasons Sinus Specimen Structure Surgeon Time Tissue Banks Tissues Translational Research United States National Institutes of Health Work airway inflammation aspirin-exacerbated respiratory disease career chronic respiratory disease chronic rhinosinusitis clinical practice experience immunoregulation improved improved outcome individual patient interest member microbial colonization microbial community mid-career faculty minimally invasive multiple omics next generation novel novel therapeutics patient oriented patient oriented research patient population personalized approach personalized care physical conditioning programs prospective skills targeted treatment transcriptomics translational research program translational scientist translational study undergraduate student

Academic Medical Centers Adult Affect Airway Disease Bacteria Biological Markers Biological Response Modifier Therapy Biological Specimen Banks Career Choice Caring Cells Characteristics Clinical Clinical Research Cohort Studies Collection Data Development Diagnosis Disease Educational Status Elderly Enrollment Environmental Risk Factor Extramural Activities Faculty Functional disorder Funding Goals Head and Neck Surgery Healthcare Heterogeneity IL4 gene Immune Immunologics Inflammation Inflammation Mediators Inflammatory Institution Interferons Interleukin-13 Interleukin-5 Interleukin-6 Intervention Knowledge Link Measurement Mediator Medical Students Mentors Mentorship Midcareer Investigator Award in Patient-Oriented Research Mucous body substance Natural Immunity Nature Operative Surgical Procedures Otolaryngology Outcome Measure Paranasal Sinus Diseases Pathogenesis Pathway interactions Patient Outcomes Assessments Patient-Focused Outcomes Patients Pattern Physicians Population Postdoctoral Fellow Prevalence Productivity Publications Quality of life Recording of previous events Research Research Personnel Research Project Grants Resources Sampling Scientific Advances and Accomplishments Scientist Seasons Sinus Specimen Structure Surgeon Time Tissue Banks Tissues Translational Research United States National Institutes of Health Work airway inflammation aspirin-exacerbated respiratory disease career chronic respiratory disease chronic rhinosinusitis clinical practice experience immunoregulation improved improved outcome individual patient interest member microbial colonization microbial community mid-career faculty minimally invasive multiple omics next generation novel novel therapeutics patient oriented patient oriented research patient population personalized approach personalized care physical conditioning programs prospective skills targeted treatment transcriptomics translational research program translational scientist translational study undergraduate student

展开

项目摘要

PROJECT SUMMARY Chronic rhinosinusitis (CRS) is a common inflammatory disease that affects a large portion of the U.S. population, resulting in poor quality of life for those affected and utilizing billions of dollars of health care resources. Efforts in my lab have focused on understanding patterns of inflammatory heterogeneity in large CRS populations with a goal of improving disease endotyping and developing personalized care pathways. I am devoted to mentoring the next generation of clinician-scientists in the field of rhinology and chronic rhinosinusitis research. The number of physicians and other surgeons pursuing clinical or translational research is declining, and this is particularly true in the fields of rhinology and otolaryngology. Maintaining a strong pipeline of trainees on research-related career paths is crucial for the development of the subspecialty and scientific advancement of the field. This will be a prospective translational cohort study to identify the clinical implications and longitudinal stability of chronic rhinosinusitis endotypes. We will enroll CRS patients through our well-established biospecimen repository and determine the stability of inflammatory mediator levels and associated endotype assignment over multiple seasons and determine whether these changes are associated with sinonasal microbial community structure. We will also confirm the longitudinal effects of two commonly used immune-modifying interventions (endoscopic sinus surgery and anti-IL4/13R biologic therapy) on inflammatory mediator levels and endotypic assignment. Collectively, these translational studies will substantially advance basic knowledge of a common airway disease that impacts millions of patients, while providing a range of investigative opportunities for mentees interested in CRS and mechanisms of upper airway inflammation. My research program is centered around a patient-oriented approach that incorporates patient-derived specimens, patient-reported outcome measures, and personalized approaches to care. I anticipate that mentee participation in this research program will lead to new and exciting avenues for patient-oriented research to further characterize CRS endotypes and evaluate the effects of targeted therapies; thus, this project will provide a conducive setting for developing the next generation of clinician-scientists in the field. I have a history of continual extramural funding, more than a decade of experience as a mentor to trainees at all levels, and institutional support to enhance my own skills that will augment the support proposed through the K24 mechanism.

项目摘要慢性鼻塞炎（CRS）是一种常见的炎症性疾病，影响美国大部分地区人口，导致受影响和利用数十亿美元医疗保健的人的生活质量差资源。我实验室的努力专注于理解大型CRS的炎症异质性的模式人群的目标是改善疾病内型和发展个性化护理途径。我是致力于指导下一代临床医生在转纹和慢性鼻孔炎领域研究。从事临床或转化研究的医师和其他外科医生的数量正在下降，在转管和耳鼻喉科领域尤其如此。保持强大的学员管道关于研究相关的职业道路对于发展和科学进步的发展至关重要田地。这将是一项前瞻性翻译队列研究，以确定临床意义和纵向慢性鼻孔炎内型的稳定性。我们将通过我们建立的良好的CRS患者注册生物循环库并确定炎症介质水平和相关内型的稳定性多个季节的分配，并确定这些变化是否与鼻纳纳纳斯微生物有关社区结构。我们还将确认两种常用免疫修饰的纵向效应炎症介质水平和内型分配。总的来说，这些转化研究将大大提高有关影响数百万患者的常见气道疾病，同时提供一系列调查机会对于对CRS感兴趣的受训者和上呼吸道发炎的机制。我的研究计划以中心为中心周围以患者为导向的方法结合了患者衍生的标本，患者报告的结果措施和个性化护理方法。我预计受训者参与该研究计划将为以患者为导向的研究带来新的令人兴奋的途径，以进一步表征CRS内型和评估目标疗法的影响；因此，该项目将为开发该领域的下一代临床医生。我有持续的壁外资金历史，不仅仅是作为各个级别的学员的导师的十年经验，以及提高我自己的技能的机构支持将增加通过K24机制提出的支持。