Evaluation of radon progeny and air pollution effects in asthma

评估氡子体和空气污染对哮喘的影响

基本信息

批准号：
10723709
负责人：
Tina Banzon
金额：
$ 20.75万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-11 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10723709
关键词：
Absenteeism Affect Air Pollutants Air Pollution Allergens Allergic Disease Asthma Award Biological Biological Markers Child Child Health Childhood Childhood Asthma Chronic Disease Chronic Obstructive Pulmonary Disease Clinical Investigator Clinical Trials Collaborations Data Data Reporting Development Diagnosis Educational Activities Enrollment Environment Environmental Epidemiology Environmental Exposure Environmental Risk Factor Epidemiology Evaluation Exhalation Exposure to FGF2 gene Funding Gases Goals Health Hospitalization IL8 gene Indoor Air Pollution Inflammation Inflammatory Infrastructure Inhalation Institution Interleukin-6 Intervention Intervention Studies Intervention Trial Learning Link Longitudinal Studies Lung Malignant neoplasm of lung Measures Mentors Modeling Morbidity - disease rate Nitric Oxide Obstructive Lung Diseases Outcome Outcomes Research Oxidative Stress Participant Particulate Matter Patients Peer Review Persons Phenotype Physical assessment Physical environment Planet Earth Policies Population Protocols documentation Public Health Schools Public Policy Publications Radiation Radioactive Radioactivity Radioisotopes Radon Regulation Research Research Personnel Research Project Grants Resources Respiratory System Risk Risk Factors Role Sampling School-Age Population Schools Serum Shapes Students Symptoms Testing Time Training United States United States National Institutes of Health Universities Uranium air cleaner airway inflammation asthma exacerbation biomarker identification carcinogenicity career career development catalyst cell injury clinical investigation cohort design disability elementary school fine particles health care service utilization high efficiency particulate air filter improved indoor allergen indoor exposure indoor pollutant inner city modifiable risk mortality novel parent grant particle particle exposure pollutant predictive modeling programs public health intervention pulmonary function remediation response skills spatiotemporal

项目摘要

PROJECT SUMMARY/ABSTRACT Research: Children exposed to indoor air pollution are known to more likely develop asthma, and in those with asthma, indoor air pollution can worsen asthma symptoms. Radon (Rn), a radioactive gas known for its lung cancer effects, decays into radiation-emitting progeny which has potential to induce cellular damage once inhaled. While residential Rn exposure is common, less is known about the non-cancer health effects of Rn decay products. Current health regulations and priorities are based solely on its carcinogenic effects in the lung. Indoor exposure to radon has been recently associated with COPD morbidity and mortality and an increased risk for hospital admissions. Given the association linking residential Rn exposure to COPD morbidity, in this exploratory application, we propose adverse health effects associated with Rn decay products via particle radioactivity in asthma morbidity, a common condition of obstructive lung disease in the pediatric population. Candidate: Dr. Banzon’s long-term goal is to become an independent NIH-funded investigator focused on the role of assessing the physical environment with a specific focus on air pollution and asthma morbidity in inner- city children. This proposal details a five-year project to provide Dr. Banzon the training and expertise necessary to study the effects of radon progeny and particle radioactivity in asthma by measuring its health effects in an established cohort of inner-city children with asthma enrolled in the School Inner-City Asthma Study (PI: Phipatanakul). Her aim is to identify a novel and modifiable environmental exposure that contributes to asthma morbidity in children. The findings have potential to aid in the design of public health intervention trials, directly inform activities regarding radon mitigation as an intervention to alleviate disability from asthma, and identify biomarkers associated with particle radioactivity which may help phenotype patients and help predict those who may have a more favorable response to personalized asthma treatment based on biomarkers. Environment: Dr. Banzon will be mentored by Dr. Phipatanakul, an expert in epidemiology, clinical trials, and clinical investigation in asthma and allergic diseases. She has assembled an extraordinary team of advisors, including Drs. Petros Koutrakis, Jonathan Gaffin, and Brett Coull, who have committed their time, resources, and expertise to facilitate Dr. Banzon’s career development and successful completion of the proposed project. During this award period, Dr. Banzon will complete complementary coursework through the Harvard School of Public Health and Harvard Catalyst Program, with a focus to hone on her skills in environmental epidemiology targeted toward air pollution and childhood asthma. The academic environment created by the mentor, institution, Harvard University, and its affiliates provides fertile ground for learning and collaborating specific to her research. Dr. Banzon will emerge an expert in the field of environmental epidemiology, with a unique understanding of the physical environmental that will shape her into a successful independent investigator.

项目概要/摘要研究：众所周知，暴露于室内空气污染的儿童更容易患哮喘，并且患有哮喘的儿童哮喘，室内空气污染会加重哮喘症状，氡气（Rn）是一种以肺部闻名的放射性气体。癌症效应，衰变成辐射发射子代，一旦发生就有可能诱发细胞损伤虽然吸入氖气很常见，但人们对氖气的非癌症健康影响知之甚少。目前的卫生法规和优先事项仅基于其对肺部的致癌作用。最近发现室内暴露于氡气与慢性阻塞性肺病（COPD）发病率和死亡率有关，并且增加考虑到居住场所接触氖气与慢性阻塞性肺病（COPD）发病率之间存在关联。探索性应用，我们通过粒子提出与 Rn 衰变产物相关的不良健康影响放射性对哮喘发病率的影响，哮喘是儿科人群阻塞性肺病的常见病症。候选人：Banzon 博士的长期目标是成为一名由 NIH 资助的独立研究者，专注于评估物理环境的作用，特别关注空气污染和哮喘发病率该提案详细介绍了一个为期五年的项目，旨在为班宗博士提供必要的培训和专业知识。通过测量氡子体和粒子放射性对健康的影响来研究氡子体和粒子放射性对哮喘的影响建立了参加学校内城区哮喘研究的内城区哮喘儿童队列（PI：她的目标是确定一种导致哮喘的新型且可改变的环境暴露研究结果有可能直接帮助设计公共卫生干预试验。为有关减少氡气的活动提供信息，作为减轻哮喘致残的干预措施，并确定与粒子放射性相关的生物标志物可能有助于对患者进行表型分析并帮助预测患者的病情可能对基于生物标志物的个性化哮喘治疗有更有利的反应。环境：Banzon 博士将得到流行病学、临床试验和流行病学专家 Phipatanakul 博士的指导。她组建了一支出色的顾问团队，致力于哮喘和过敏性疾病的临床研究，包括 Petros Koutrakis 博士、Jonathan Gaffin 和 Brett Coull 博士，他们投入了时间、资源，和专业知识，以促进 Banzon 博士的职业发展和成功完成拟议项目。在此奖励期间，班宗博士将通过哈佛大学完成补充课程公共卫生和哈佛催化剂计划，重点是磨练她在环境流行病学方面的技能针对空气污染和儿童哮喘的学术环境由导师、机构、哈佛大学及其附属机构为她的研究提供了学习和合作的肥沃土壤。班宗博士将成为环境流行病学领域的专家，对环境流行病学有着独特的理解。物理环境将使她成为一名成功的独立调查员。