IGF::OT::IGF High-plex Pharmacodynamic Biomarker Assay

IGF::OT::IGF 多重药效生物标志物测定

基本信息

批准号：
9581565
负责人：
RALPH PARCHMENT
金额：
$ 2526.66万
依托单位：
LEIDOS BIOMEDICAL RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-21 至 2022-09-20
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9581565
关键词：
Affect Algorithmic Analysis Antibodies Apoptosis Biochemical Biological Assay Biological Markers Biological Tumor Markers Biopsy Cell Death Cell Survival Clinical Clinical Trials Complex DNA Repair Detection Development Drug Evaluation Epithelial Functional Imaging Histology Human Humor Image Analysis Imaging Techniques Laboratories Link Measures Medical Imaging Meiosis Membrane Mesenchymal Mismatch Repair Modeling Necrosis Needles Oxidases Patients Pharmaceutical Preparations Pharmacodynamics Reproducibility Sampling Stress System Technology Technology Transfer Testing Tumor Immunity United States National Institutes of Health Validation biological systems cancer cell design drug development endoplasmic reticulum stress fitness molecular imaging neoplastic cell oxidative DNA damage pharmacodynamic biomarker repaired response stemness targeted cancer therapy tumor

项目摘要

Pharmacodynamics is the drug-induced response of a biological system and it can be assessed and quantitated using molecular, physiological and medical imaging techniques. As part of DCTD’s support for targeted cancer therapies, it is necessary to develop useful and reliable assays that can guide drug development and be used to understand the biochemical changes that are part of the evaluation of drug response in clinical trial patients. This project supports the design, development, validation and demonstration of fitness-for-purpose of a new multiplex assay for the analysis and quantitation of important biological markers of tumor cell death or survival. These robust assays will be created to support testing of humor tumor biopsies collected during the conduct of human clinical trials and will investigate the linkage between ER stress, oxidative DNA damage and repair, and tumor cell death.

药效学是药物诱导的生物系统反应，可以使用分子、生理和医学成像技术对其进行评估和定量，作为 DCTD 支持癌症靶向治疗的一部分，有必要开发有用且可靠的检测方法来指导药物。该项目支持设计、开发、验证和演示用于分析和定量的新型多重检测的适用性。具有重要生物意义的这些强大的检测方法将用于支持对人体临床试验期间收集的体液肿瘤活检进行测试，并将研究 ER 应激、氧化 DNA 损伤和修复以及肿瘤细胞死亡之间的联系。