INFLUENCE OF BENZO(A)PYRENE ON OVARIAN FUNCTION

苯并(A)芘对卵巢功能的影响

• 批准号: 7561523
• 负责人: Anthony E. Archibong
• 金额: $ 14.5万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561523
• 关键词: Acute; Adverse effects; Animals; Anodes; Area; Aromatic Polycyclic Hydrocarbons; Automobile Exhaust; Benzo(a)pyrene; Biological Availability; Carbon; Coal; Coke; Computer Retrieval of Information on Scientific Projects Database; Condition; Consumption; Corpus Luteum Maintenance; Data Set; Development; Electrodes; Environment; Estrous Cycle; Exposure to; Family; Female; Fertilization; Food; Funding; Gonadal Steroid Hormones; Grant; Hazardous Waste Sites; Heating; High temperature of physical object; Home environment; In Vitro; Individual; Industry; Ingestion; Institution; Investigation; Life; Natural graphite; Numbers; Occupational Exposure; Ovarian; Pituitary Hormones; Plasma; Probability; Process; Rattus; Relative (related person); Research; Research Personnel; Resources; Risk; Risk Assessment; Soil; Source; Steroids; Toxic effect; Toxicokinetics; Treatment Protocols; United States National Institutes of Health; Water; Wood material; cigarette smoking; cooking; exposed human population; implantation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NOTE: Tables and Figures were uploaded with the Overall Research Summary file. BACKGROUND The polycyclic aromatic hydrocarbon (PAH) family includes 100 different compounds. These compounds are formed from natural and synthetic sources that involve high-temperature pyrolytic processes, but PAHs originating from synthetic sources is quantitatively the most important in terms of environmental distribution. Human exposure to PAHs has been attributed to home heating and cooking using coal or wood, cigarette smoking, automobile exhaust emissions, consumption of contaminated foods, occupational exposure in coke, graphite-electrode and carbon-anode manufacturing industries. PAHs has also been found at a large number of National Priorities List (NPL) or Superfund hazardous waste sites. The toxicity of PAHs has been studied by a number of investigators under in vitro conditions and there have been no attempts to study FLA toxicity in a subchronic regimen. For risk estimation, long-term animal exposure to commonly occurring PAHs is essential. Quantitative risk assessment of PAHs has been hampered by the lack of sufficient data sets from animal studies. Information relative to acute and subchronic exposures through ingestion of water, food, or soil contaminated with PAH is vital in assessing the risk to individuals living in areas surrounding hazardous waste sites. Because of the widespread availability of PAH in the environment and the considerable probability of human exposure, the potential adverse effects of this compound merit investigation SPECIFIC AIMS 1) To determine the bioavailability and toxicokinetics of benzo(a)pyrene in female rats. 2) To determine the effect of BaP treatment on plasma concentrations of gonadal steroids and the pituitary hormones that regulate these steroids during the rat estrous cycle. 3) To determine the effect of BaP on ovarian exocrine function and luteal maintenance. 4) To determine the effect of BaP on fertilization and pre-implantation development.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 注意：将表和数字上传到了总体研究摘要文件中。 背景 多环芳烃（PAH）家族包括100种不同的化合物。这些化合物是由涉及高温热解过程的自然和合成来源形成的，但是源自合成来源的PAH在环境分布方面是数量上最重要的。人类接触PAH的归因于使用煤炭或木材，吸烟，汽车排气排放，污染食品的消费，可口可乐的职业曝光，石墨 - 电极和碳 - 氧化管制造工业的职业曝光。在大量国家优先级列表（NPL）或超级基金危险废物场所也发现了PAHS。 在体外条件下，许多研究人员已经对PAH的毒性进行了研究，并且没有尝试研究亚基疗法中的FLA毒性。为了估计风险，长期动物暴露于常见发生的PAH是必不可少的。 由于缺乏动物研究的足够数据集，对PAH的定量风险评估受到了阻碍。通过摄入水，食物或PAH污染的土壤与急性和亚基暴露有关的信息对于评估生活在危险废物地点周围地区的人的风险至关重要。 由于PAH在环境中的广泛可用性以及人类暴露的可能性很大，因此该化合物优点研究的潜在不利影响 具体目标 1）确定雌性大鼠苯并（a）pyrene的生物利用度和毒性。 2）确定BAP处理对在大鼠发情循环中调节这些类固醇的性腺类固醇血浆浓度和垂体激素的影响。 3）确定BAP对卵巢外分泌功能和黄体维持的影响。 4）确定BAP对受精和植入前发育的影响。