Expanding WNPRC Resources for AIDS-Related Research

扩大 WNPRC 艾滋病相关研究的资源

基本信息

批准号：
7249563
负责人：
Joseph W. Kemnitz
金额：
$ 63.91万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-15 至 2009-10-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7249563
关键词：
AIDS Vaccines Acquired Immunodeficiency Syndrome Affect Age Aging Alleles Animal Housing Animal Model Animal Viruses Animals Applications Grants Area Biological Biology Callithrix jacchus jacchus Caloric Restriction Cell Line Cercopithecus pygerythrus Culture Media Degenerative polyarthritis Development Diabetes Mellitus ES Cell Line Fertility Study Funding Gene Expression Genetic Genome Goals Grant HIV Head Health Health Benefit Home environment Housing Human IACUC Immune response Immunogenetics Immunologic Deficiency Syndromes Incidence Lipids Macaca Macaca fascicularis Macaca mulatta Major Histocompatibility Complex Mauritius Metabolic Diseases Mission Modeling Nerve Degeneration Numbers Obesity Osteoporosis Ovarian Parkinson Disease Plasma Primates Protocols documentation Quality of life Reagent Regulation Reproduction Research Research Personnel Resources SIV Safety Scientist Span 20 Specimen Stem cells Syndrome System Testing Transplantation Virus Water Wisconsin animal resource base cardiovascular disorder risk design embryonic stem cell endometriosis experience improved nonhuman primate novel programs reproductive neuroendocrinology vaccine evaluation virology virus pathogenesis

项目摘要

DESCRIPTION (provided by applicant): The primary objectives of the SIV program at the Wisconsin National Primate Research Center (WNPRC) are to understand the attributes of effective anti-immunodeficiency virus immune responses, develop novel AIDS vaccines, and expand the HIV animal model to include the unique genetic attributes of cynomolgus macaques (Macaca fasicularis) from Mauritius. The WNPRC is experiencing a critical shortage of animal housing which will directly affect continued advances in AIDS research. Our current SIV housing facility is near capacity and will be insufficient for our long-term housing needs. Inadequate housing will soon become a limiting factor when designing new studies. We currently have space for 120 SIV-infected macaques, and animals on active studies occupy 82 of those spaces. A conservative estimate of the number of additional animals needed in 2008 using funding already in place is 142. This estimate does not include large studies where pending funding could push this number well beyond 250 animals. The primary goal of this G20 grant proposal is to renovate an existing specimen storage area, which is adjacent to the existing SIV housing area, into three new animal housing rooms. Funding is also requested for sufficient caging and an automatic watering system to equip these new animal rooms. Completing this renovation will provide the critical space necessary for the SIV program to expand at the WNPRC and for the investigators to continue their ground-breaking research.

DESCRIPTION (provided by applicant): The primary objectives of the SIV program at the Wisconsin National Primate Research Center (WNPRC) are to understand the attributes of effective anti-immunodeficiency virus immune responses, develop novel AIDS vaccines, and expand the HIV animal model to include the unique genetic attributes of cynomolgus macaques (Macaca fasicularis) from Mauritius. WNPRC严重缺乏动物住房，这将直接影响艾滋病研究的持续进展。我们目前的SIV住房设施接近容量，不足以满足我们的长期住房需求。在设计新研究时，住房不足将很快成为一个限制因素。目前，我们有120个SIV感染猕猴的空间，而活跃研究的动物占据了其中82个空间。对2008年使用资金所需的其他动物数量的保守估计为142。此估计不包括大型研究，即待筹资金可能会将这一数量推高超过250只动物。该G20赠款提案的主要目的是将现有的标本存储区域翻新，该标本存储区与现有的SIV住房区相邻，为三个新的动物住房室。还要求资金提供足够的笼子和一个自动浇水系统，以配备这些新的动物室。完成这项翻新将为SIV计划在WNPRC扩展和调查人员继续开创性研究所需的关键空间。