Advanced Fabrication and Testing Core (AFT)

先进制造和测试核心 (AFT)

基本信息

批准号：
10714165
负责人：
Hai Xiao
金额：
$ 28.96万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10714165
关键词：
3-Dimensional 3D Print Applications Grants Area Automation Award Biocompatible Materials Biological Biomedical Engineering Centers of Research Excellence Ceramics Client Clinical Complex Diagnosis Discipline Engineering Equipment Event Funding Generations Glass Goals Grant Hand Harvest Health Image Imaging technology In Situ Industrialization Lasers Light Measurement Mechanics Mentors Metals Mind Molecular Musculoskeletal Musculoskeletal Diseases Optics Patients Phase Physical environment Pilot Projects Procedures Process Program Sustainability Publications Research Research Personnel Research Project Grants Research Proposals Research Support Resources Secure Services Source South Carolina Standardization Strategic Planning System Technology Testing Time Tissues Training Training Activity Translating Translations United States National Institutes of Health Universities Validation Work data acquisition design engineering design experience fabrication graphical user interface human model improved innovation instrument instrumentation manufacture manufacturing systems meetings member models and simulation multidisciplinary operation programs prototype second harmonic sensor signal processing success technological innovation tool virtual human

项目摘要

SUMMARY The Advanced Fabrication and Testing (AFT) Core is the enabling technological engine of the SC-TRIMH. It harvests the unique engineering strengths and capabilities at Clemson University to support the research projects and expedite the translation of their innovations to patient-specific diagnosis and treatments of musculoskeletal diseases at the molecular, cellular, tissue, and body levels. In Phase I, the AFT Core expanded to now cover over 4,400 sq ft when it consolidated all its services in a new building in order to provide more centralized services for electrical, mechanical, optical, and material designs, rapid prototyping, sensors and instrumentation, and advanced testing for the TRIMH investigators. The core also expanded its instrumentation (e.g. integrated additive and subtractive manufacturing, plus femtosecond laser for ultrafast micromachining) via awards from DOE and a TRIMH supplement. During this time the AFT Core provided services to all 8 TRIMH Research Project Leaders (RPL), 8 other TRIMH Pilot Project Leaders, and 12 Clemson PIs. Seven other PIs from the state of South Carolina (SC) and 6 others outside SC used this core; along with three industrial clients. This core is especially important to those who do not have primary expertise in the engineering disciplines, as we have both turnkey services and tailored “hand holding”/mentoring. The AFT core in Phase I has supported nearly 50 PIs, contributed to 30 grant applications, and generated more than 30 publications. In Phase II, we will be supporting the research projects of all 4 RPLs while we continue to expand and sustain the engineering capabilities and strive to build the AFT Core into a leading biomedical engineering resource, especially for musculoskeletal related research at Clemson University, South Carolina, and beyond. The goal will be achieved by three specific aims: Aim 1: expand and sustain the design and rapid prototyping capabilities to enable TRIMH researchers to quickly design and build simulated musculoskeletal components, systems or environments that are physical and biological replica of the human models, Aim 2: expand and sustain the sensor, instrumentation, and testing capabilities to enable the investigators to design, fabricate and install sensors onto the physical and biological replica for in situ measurement of various parameters and validation of the virtual human models, and Aim 3: promote and sustain the AFT core as a leading biomedical engineering “go-to-place” for musculoskeletal research at Clemson University, the state of South Carolina, and beyond. The AFT Core will be led by a multidisciplinary team with the combined expertise in engineering designs (mechanical, optical, electrical, and material), advanced manufacturing, rapid prototyping, sensors, instrumentation, imaging, and advanced testing. The COBRE funds will continue to support experienced staff members to operate/maintain the consolidated facilities, to train/mentor TRIMH investigators to translate their innovations into clinical successes, to further enhance the capability of the core, and to facilitate the transition of the AFT Core to a competitive and self- sustained program.

概括先进制造和测试 (AFT) 核心是 SC-TRIMH 的技术引擎。收获克莱姆森大学独特的工程优势和能力来支持研究项目并加快将其创新成果转化为针对患者的诊断和治疗方法分子、细胞、组织和身体水平的肌肉骨骼疾病在第一阶段，AFT 核心得到扩展。为了提供更多服务，将所有服务整合到一座新建筑中，现在占地超过 4,400 平方英尺电气、机械、光学和材料设计、快速原型、传感器和该核心还扩展了其仪器。（例如集成增材和减材制造，加上用于超快微加工的飞秒激光器）在此期间，AFT 核心为所有 8 个 TRIMH 提供服务。研究项目负责人 (RPL)、其他 8 名 TRIMH 试点项目负责人以及 12 名克莱姆森 PI 其他 7 名 PI。来自南卡罗来纳州 (SC) 和 SC 以外的其他 6 个国家以及三个工业客户使用了该核心。这个核心对于那些不具备工程学科主要专业知识的人来说尤其重要，因为我们拥有交钥匙服务和量身定制的“手把手”/指导，第一阶段的 AFT 核心提供了支持。在第二阶段，我们与近 50 名 PI 合作，提交了 30 份资助申请，并发表了 30 多篇出版物。将支持所有 4 个 RPL 的研究项目，同时我们继续扩展和维持工程力争将AFT核心打造成领先的生物医学工程资源，特别是南卡罗来纳州克莱姆森大学及其他地区的肌肉骨骼相关研究将实现这一目标。通过三个具体目标：目标 1：扩展和维持设计和快速原型制作能力，以实现 TRIMH 研究人员快速设计和构建模拟肌肉骨骼组件、系统或环境是人体模型的物理和生物复制品，目标 2：扩展和维持传感器、仪器、和测试能力，使研究人员能够设计、制造传感器并将其安装到物理和环境上用于原位测量各种参数和验证虚拟人体模型的生物复制品，以及目标 3：促进和维持 AFT 核心作为肌肉骨骼领域领先的生物医学工程“首选” 南卡罗来纳州克莱姆森大学及其他地区的研究将由 AFT 核心领导。多学科团队，具有工程设计（机械、光学、电气和材料）、先进制造、快速原型、传感器、仪器仪表、成像和先进测试。 COBRE 资金将继续支持经验丰富的工作人员运营/维护合并的设施，培训/指导 TRIMH 研究人员将他们的创新转化为临床成功，进一步提升核心能力，促进AFT核心向有竞争力、自主化的转型持续的计划。