Mapping links between real-world diversity, positive emotion, and neural dynamics in anhedonia

映射现实世界多样性、积极情绪和快感缺失的神经动力学之间的联系

• 批准号: 10716446
• 负责人: AARON S HELLER
• 金额: $ 62.52万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10716446
• 关键词: Address; Affect; Affective; Age; Anhedonia; Antidepressive Agents; Automobile Driving; Behavior; Biological; Brain; Businesses; Censuses; Chronic stress; Clinical; Clinical Trials; Complex; Data; Depressed mood; Dimensions; Disease; Emotions; Ethnic Origin; Exercise; Exploratory Behavior; Female; Functional Magnetic Resonance Imaging; Gender; Geography; Green space; Hippocampus; Human; Incidence; Individual; Injections; Intervention; Link; Location; Maps; Measures; Mental Depression; Mental Health; Mental disorders; Methods; Neighborhoods; Nucleus Accumbens; Oceans; Pathway interactions; Patients; Population Density; Post-Traumatic Stress Disorders; Predisposition; Property; Race; Recording of previous events; Recovery; Recreation; Rest; Restaurants; Rewards; Role; Sampling; Science; Severities; Social Interaction; Stress; Suicide; Symptoms; Testing; Travel; Treatment Efficacy; Treatment Failure; Unemployment; Variant; Visit; Work; avoidance behavior; depressive symptoms; design; disability; effective intervention; experience; improved; mortality risk; negative affect; neural; neural circuit; neural network; neuroimaging; neuromechanism; positive emotional state; pre-clinical; preclinical study; recruit; sociodemographics; stress symptom; therapy development

PROJECT SUMMARY Reduced positive affect is a core symptom of many stress-related psychiatric disorders, including depression and PTSD. Critically, positive affect is not simply the inverse of negative affect, and clinicians struggle to increase positive affect: Antidepressant and psychotherapeutic interventions often reduce depressed mood but are ineffective at increasing positive affect. And yet, qualitative studies of patients themselves indicate that a ‘full recovery’ requires increasing positive emotion, even when other depressive symptoms have subsided. Despite the critical role of positive emotion, very limited work has identified effective interventions to increase real-world positive affect to improve mental health. Guided by preclinical work, we recently discovered that positive affect is increased when going to a greater number of varied locations (“experiential diversity”). Moreover, the association between experiential diversity and positive affect appears to be supported specifically by functional connectivity between the hippocampus and nucleus accumbens–a stress susceptible circuit responsible for assigning reward value to novelty. This finding suggests that increasing experiential diversity may be a plausible real-world intervention to increase positive affect by strengthening specific neural circuits. Leveraging a strong team with complimentary expertise in mobile tracking, resting state fMRI, treatment development, and affective science, this R01 application will expand these initial findings in a large, demographically representative sample encompassing a range of anhedonia severity (from asymptomatic to severe) collecting geolocation (GPS), experience sampling of emotion, and functional MRI to, (1) precisely delineate the specific geospatial features of experiential diversity most strongly linked to increases in momentary (EMA measured) positive affect (e.g., neighborhoods one has never visited, green spaces, beach/ocean); (2) determine whether individuals with higher levels of anhedonia have similar affective benefits from these types of experiential diversity as individuals with lower experiential diversity; (3) determine the neural network circuit mechanisms supporting associations between experiential diversity and affect as a function of anhedonia; and (4) in an independent sample, experimentally induce experiential diversity to determine if it causes increased positive affect. Results from this application will help to define the neural mechanisms by which exploration and experiential diversity predict increases in positive affect and will yield actionable real-world interventions for a clinical trial to improve positive affect in those with heightened anhedonia.

项目摘要 降低积极影响是许多与压力有关的精神疾病的核心症状，包括抑郁症 和PTSD。至关重要的是，积极影响不仅是负面影响的倒数，临床医生难以增加 积极影响：抗抑郁药和心理治疗干预措施通常会减轻情绪抑郁，但是 在增加积极影响方面无效。然而，对患者本身的定性研究表明， 即使其他抑郁症状消退，恢复也需要增加积极的情绪。 尽管积极情绪的重要作用至关重要，但工作非常有限，已经确定了有效的干预措施以增加 现实世界的积极影响，以改善心理健康。在临床前工作的指导下，我们最近发现 当进入更多不同的位置时，积极影响会增加（“体验式多样性”）。 此外，经验丰富的多样性和积极影响之间的关联似乎得到了特别的支持 通过海马和核核之间的功能连通性 - 应力易感电路 负责将奖励价值分配给新颖性。这一发现表明，增加经验多样性 可能是一种合理的现实干预措施，可以通过增强特定的神经回路来增加积极影响。 利用一支具有免费专业知识的强大团队在移动跟踪，休息状态fMRI，治疗 发展和情感科学，此R01应用程序将在大型， 在人口统计学上表示样本，包括一系列的抗抗激症（从无症状到 严重）收集地理位置（GPS），经验情绪抽样以及功能性MRI，（1）精确 描述经验丰富的多样性的特定地理空间特征，最有很强的联系，以增加瞬间 （EMA测量）积极影响（例如，一个从未参观过的社区，绿色空间，海滩/海洋）； （2） 确定Anhedonia水平较高的人是否从这些类型的 经验多样性的个人的体验多样性； （3）确定神经网络电路 支持经历的多样性和影响与阿尼多尼亚的函数之间关联的机制；和 （4）在独立样本中，在实验中引起经验多样性，以确定它是否导致增加 积极影响。该应用的结果将有助于定义探索和探索的神经机制 体验式多样性预测积极影响的增加，并将对A产生可行的现实世界干预措施 临床试验可改善抗议激增的人的积极影响。