Training Grant in Circadian and Sleep Research

昼夜节律和睡眠研究培训补助金

• 批准号: 9251844
• 负责人: FRED W TUREK
• 金额: $ 45.33万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9251844
• 关键词: Circadian Rhythms; Grant; Research; Sleep; Training

DESCRIPTION (provided by applicant): This is a resubmission of a renewal application for continued support of an established T32 Training Grant in Circadian and Sleep Research to train and support predoctoral and postdoctoral students at Northwestern University (NU) and the University of Chicago (U of C). The integration of circadian biology and sleep research in both animal models and humans has been the cornerstone of the relationship between the preceptors on this Training Grant at the U of C and NU for over 20 years, and we have added the term "circadian" to the title of our Training Program in recognition of the importance of combining these fields in the training of the next generation of young investigators. This Training Program will be led by two established senior investigators under the Multiple Leadership Plan and will involve 13 Primary Training Faculty who have their primary appointments in either basic science or clinical departments. The proposed Training Program will offer predoctoral and postdoctoral students interdisciplinary and multidisciplinary training in a wide range of scientifi disciplines that are highly relevant to understanding the function, regulation and health implications of sleep and circadian rhythmicity. Central to this Program is the training of student in modern basic science, translational research as well as patient oriented research. Multiple research perspectives have fueled for more than a decade the productive interactions and cross-fertilization that have developed between the preceptors in this Program. During the current grant period, the scope of the research activities of the Training Faculty has expanded to include bench to bedside investigations of the impact of sleep-disordered breathing on metabolism and cardiovascular function and we propose to further broaden the program in our renewed program with the addition of six outstanding physician-scientists to the training faculty. As our nation is facing unprecedented epidemics of obesity, diabetes and their cardiovascular consequences, the Training Program proposed in the present application is uniquely positioned to train an interdisciplinary workforce of academic and industry investigators as well as government decision makers to address the roles of sleep disturbances and circadian dysfunction in these public health challenges. A key feature of our Training Program is the inclusion of 10 Collaborating Faculty with additional clinical, scientific and/or educational expertise that greatly enhances our training environment, and conversely, they will benefit from their participation in the program by developing mentoring skills. Our Program will enable trainees to integrate cutting edge approaches and techniques in the areas of genetics, genomics, endocrinology, metabolism, pharmacology, neurobiology, pulmonology, cognitive neuroscience, gerontology and chronobiology into their training in sleep and circadian research. Because the preceptors in this Training Program are actively involved in research at the molecular, cellular, systems, behavioral and epidemiological levels, trainees will be trained in a rich environment of activities that are integrated together for the study of the basic mechanisms of sleep and circadian function at all levels of biological organization.

描述（由申请人提供）：这是重新提交续签申请，以继续支持已建立的昼夜节律和睡眠研究 T32 培训补助金，以培训和支持西北大学 (NU) 和芝加哥大学 (U) 的博士前和博士后学生。 C）。 20多年来，昼夜节律生物学和睡眠研究在动物模型和人类中的整合一直是加州大学和NU的培训资助导师之间关系的基石，我们在其中添加了“昼夜节律”一词我们的培训计划的标题是为了认识到将这些领域结合起来培训下一代年轻研究人员的重要性。本次培训 该计划将由两名资深研究人员根据多重领导计划领导，并将涉及 13 名初级培训教员，他们的主要任命要么是基础科学要么是临床部门。拟议的培训计划将为博士前和博士后学生提供广泛的科学学科的跨学科和多学科培训，这些培训与理解睡眠和昼夜节律的功能、调节和健康影响高度相关。该项目的核心是对学生进行现代基础科学、转化研究以及以患者为导向的研究方面的培训。十多年来，多种研究视角推动了该计划导师之间富有成效的互动和交叉授精。在当前资助期内，培训学院的研究活动范围已扩大到包括睡眠呼吸障碍对新陈代谢和心血管功能影响的实验室到临床研究，我们建议在我们的新计划中进一步扩大该计划培训师队伍中增加了六名杰出的医师科学家。由于我国正面临前所未有的肥胖、糖尿病及其心血管后果的流行，本申请中提出的培训计划具有独特的定位，可以培训由学术和行业研究人员以及政府决策者组成的跨学科劳动力，以解决睡眠障碍的作用这些公共卫生挑战中的昼夜节律失调。我们培训计划的一个关键特点是纳入了 10 名具有额外临床、科学和/或教育专业知识的合作教师，这极大地改善了我们的培训环境，相反，他们将通过发展指导技能从参与该计划中受益。我们的计划将使学员能够将遗传学、基因组学、内分泌学、新陈代谢、药理学、神经生物学、肺病学、认知神经科学、老年学和时间生物学领域的前沿方法和技术融入到他们的睡眠和昼夜节律研究培训中。由于本次培训项目的导师积极参与分子、细胞、系统、行为和流行病学层面的研究，学员将在丰富的活动环境中接受培训，这些活动整合在一起，研究睡眠和昼夜节律的基本机制在生物组织的各个层次上发挥作用。