Peripersonal Space Representation as a Basis for Social Deficits in Autism and Schizophrenia Spectrum Disorders

周围空间表征作为自闭症和精神分裂症谱系障碍社会缺陷的基础

• 批准号: 9236221
• 负责人: Carissa J Cascio
• 金额: $ 19.75万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-03 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9236221
• 关键词: Address; Adult; Attention; Autacoids; Autistic Disorder; Behavioral; Categories; Clinical; Cognitive; Complex; Control Groups; Development; Diagnostic; Disease; Distal; Empathy; Exhibits; Foundations; Future; Goals; Hearing; Impairment; Individual; Intervention; Intervention Studies; Investigation; Knowledge; Link; Location; Measurement; Measures; National Institute of Mental Health; Ownership; Perception; Persons; Phenotype; Plasticizers; Population; Predisposition; Proprioception; Questionnaires; Reciprocal Social Interaction; Schizophrenia; Sensory; Sensory Process; Social Behavior; Social Functioning; Social Interaction; Stress; Symptoms; Tactile; Testing; Touch sensation; Training; Vision; Visit; Visual; Weight; autism spectrum disorder; base; clinically relevant; follow-up; multisensory; novel; public health relevance; relating to nervous system; response; social; spatiotemporal; statistics; stem; translational approach; visual stimulus

 DESCRIPTION (provided by applicant): The objective of the proposed project is to compare and contrast multisensory representation of peripersonal space (PPS) in two clinical groups: adults with autism spectrum disorder (ASD) and schizophrenia (SZ). The NIMH has stressed the importance of investigations that cross diagnostic categories and identify neural substrates of symptoms that are both shared and divergent across clinical groups. This project will follow this directive and extend it by focusing on basic sensory processes, which underlie more complex behavioral phenotypes and for which the neural bases are more completely understood. The project will assess the size and gradient of PPS representation in these two groups, within the hypothetical framework that shared social deficits exhibited in both groups may arise from divergent deficits in the multisensory representation of PPS. Individuals with ASD may show smaller representations of PPS and steeper gradients between PPS and extrapersonal space (EPS), reflecting a proximal focus of attention that leads to difficulty with reciprocal social interaction. In contrast, individuals with SZ are expected to show expanded PPS representation and shallower gradients between PPS and EPS, reflecting a distal or external focus that leads to problems distinguishing ownership. Both aberrant representations are predicted to relate to the specific social deficits observed in each group. We will also explor the malleability of these representations following a period of paired visual-tactile stimulation, which has been demonstrated to alter PPS representation in adults. While this exploratory aim is not designed to assess manipulating PPS representation as a treatment, and thus does not constitute an intervention study, we will assess the relationship between changes in PPS representation and social symptoms in each group as a preliminary step in determining whether there are links between these domains in ASD and SZ.

 描述（由申请人提供）：拟议项目的目的是比较和对比临床两组中个人周围空间（PPS）的多感觉表征：患有自闭症谱系障碍（ASD）和精神分裂症（SZ）的成年人。跨诊断类别并识别跨临床群体共有和不同的症状的神经基础的研究的重要性该项目将遵循这一指令，并通过关注基本的感觉过程来扩展它，这些过程是更复杂的行为的基础。该项目将在假设框架内评估这两组人的 PPS 表征的大小和梯度，即两组人所表现出的共同社交缺陷可能源于多感官表征的不同缺陷。 PPS。患有 ASD 的个体可能表现出较小的 PPS 表征以及 PPS 和外部空间 (EPS) 之间的陡峭梯度，这反映了注意力的最近焦点，导致了相互社交互动的困难。 SZ 预计会显示出扩大的 PPS 代表性以及 PPS 和 EPS 之间较浅的梯度，这反映了导致区分所有权问题的远端或外部焦点，预计这两种异常的代表性都与每个群体中观察到的特定社会缺陷有关。经过一段时间的视觉-触觉配对刺激后，这些表征的可塑性已被证明可以改变成人的 PPS 表征，虽然这一探索性目的并不是为了评估操纵 PPS 表征作为一种治疗方法，因此不构成干预研究，我们将评估每组中 PPS 表征的变化与社会症状之间的关系，作为确定 ASD 和 SZ 中这些领域之间是否存在联系的初步步骤。