Defining Diabetes in Youth

青年糖尿病的定义

• 批准号: 7501599
• 负责人: RICHARD F HAMMAN
• 金额: $ 12.45万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7501599
• 关键词: Address; Adult; African American; Age; American Indians; Ancillary Study; Apolipoproteins B; Area; Behavioral; Birth Weight; Blood Pressure; Body Size; Breast Feeding; C-reactive protein; Cardiovascular Diseases; Case-Control Studies; Centers for Disease Control and Prevention (U.S.); Central obesity; Cholesterol; Clinical; Colorado; Control Groups; Data; Data Analyses; Diabetes Mellitus; Diagnosis; Diet; Dietary intake; Education; Epidemiologic Studies; Epidemiology; Ethnic group; Exposure to; Family; Family history of; Fathers; Fibrinogen; Frequencies; Functional disorder; Funding; Gender; Height; High Density Lipoprotein Cholesterol; High Prevalence; Hispanics; Hypertension; Hypertriglyceridemia; Immunologics; Income; Insulin Resistance; Interleukin-6; Laboratories; Low Birth Weight Infant; Low Prevalence; Low-Density Lipoproteins; Matched Group; Measurement; Measures; Medical Records; Metabolic; Metabolic syndrome; Minority; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Parents; Pattern; Physical activity; Plasminogen Inactivators; Population; Pregnancy; Prevalence; Primary Health Care; Protein C; Protocols documentation; Psychosocial Factor; Recording of previous events; Recruitment Activity; Registries; Relative (related person); Research; Research Personnel; Risk; Risk Factors; Source; South Carolina; Syndrome; Testing; Thinking; Triglycerides; Weight; Youth; aged; cardiovascular risk factor; case control; data management; depressive symptoms; design; disorder risk; experience; insulin secretion; macrovascular disease; maternal diabetes; non-diabetic; prenatal; programs; saturated fat

There is very limited information about the epidemiology of Type 2 diabetes mellitus in youth, though it is believed that the prevalence is increasing rapidly. Risk factors similar to those in adults with Type 2 are thought to be important, (e.g.obesity, insulin resistance, diet, physical activity, positive family history), however, there are no reliable epidemiologic studies of these risk factors in youth with type 2 diabetes using appropriate controls. In addition, risk factors such as low birth weight, lack of breast-feeding, maternal diabetes during pregnancy and family dysfunction and depressive symptoms have received little epidemiologic study in populations other than American Indians. This proposal addresses the lack of such studies. The Defining Diabetes in Youth (DDY) project will focus on type 2 diabetes in youth aged 10-19, drawing upon the CDC funded SEARCH diabetes registry project in Colorado and South Carolina. The SEARCH project will ascertain all cases of diabetes in youth, collect immunologic, clinical, and metabolic information, and classify cases as Type 1 or 2 diabetes. DDY will only have to recruit appropriate controls aged 10-19 from three ethnic backgrounds including African Americans (AA), Hispanics (H), and non-Hispanic whites (NHW) to test specific etiologic hypotheses in the cases classified by SEARCH as Type 2 diabetes. It will also explore cardiovascular risk factor differences in youth with Type 2 diabetes and controls, and will evaluate insulin resistance and secretion differences among controls by level of obesity and other factors. The primary design is a case-control study, through which risk factors for diabetes, selected complications and CVD risk factors will be evaluated. The current proposal is an approved SEARCH ancillary study. Collaborating investigators bring expertise in multiple areas relevant to diabetes in youth, and experience in large _pidemiologic studies of diabetes (both type 1 and 2) in minority populations. Given the low prevalence of Type 2 in Youth, DDY is an efficient design, since case ascertainment and typing will be conducted by SEARCH, and only control recruitment, addition of new measures, and analysis are requested. The biostatistical analysis, data management and "entral laboratory will be the same as used in SEARCH.

关于年轻人中2型糖尿病的流行病学的信息非常有限，尽管人们认为 患病率正在迅速增加。与2型成年人相似的风险因素被认为很重要， （例如，肥胖，胰岛素抵抗，饮食，体育锻炼，积极的家族史），但是，没有可靠的 使用适当的对照组对2型糖尿病青年中这些危险因素的流行病学研究。另外，风险 诸如低出生体重，缺乏母乳喂养，怀孕期间母亲糖尿病等因素以及家庭功能障碍 除美国印第安人以外的人群中，抑郁症状几乎没有得到流行病学研究。这 提案解决了缺乏此类研究的问题。 青年定义糖尿病（DDY）项目将重点关注10-19岁青年的2型糖尿病 CDC资助的搜索糖尿病注册表项目在科罗拉多州和南卡罗来纳州。搜索项目将确定全部 青年糖尿病病例，收集免疫学，临床和代谢信息，并将病例分类为1或2 糖尿病。 DDY只需要从包括非洲在内的三个族裔背景中招募10-19岁的适当控制 美国人（AA），西班牙裔（H）和非西班牙裔白人（NHW）在案例中检验特定的病因学假设 通过搜索分类为2型糖尿病。它还将探索2型青年的心血管风险因素差异 糖尿病和对照，并将评估肥胖水平对照组之间的胰岛素抵抗和分泌差异 和其他因素。主要设计是一项病例对照研究，通过该研究选择了糖尿病的危险因素 将评估并发症和CVD风险因素。当前的提案是一项认可的搜索辅助研究。 合作调查人员在与青年糖尿病有关的多个领域中带来了专业知识，并在庞大的方面经验 _在少数群体中的糖尿病（1型和2型）的培养基研究。鉴于2型的患病率较低 青年，DDY是一种有效的设计，因为案例确定和键入将通过搜索进行，只有控制 请求招聘，增加新措施和分析。生物统计分析，数据管理和 “ Entral实验室将与搜索中使用的实验室相同。

项目成果

Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study.

• DOI: 10.2337/dc07-2417
• 发表时间: 2008-07
• 期刊: DIABETES CARE
• 影响因子: 16.2
• 作者: Dabelea, Dana;Mayer-Davis, Elizabeth J.;Lamichhane, Archana P.;D'Agostino, Ralph B.;Liese, Angela D.;Vehik, Kendra S.;Narayan, K. M. Venkat;Zeitler, Phillip;Hamman, Richard F.
• 通讯作者: Hamman, Richard F.

Cardiovascular risk factors among youth with and without type 2 diabetes: differences and possible mechanisms.

• DOI: 10.2337/dc08-1442
• 发表时间: 2009-01
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: West NA;Hamman RF;Mayer-Davis EJ;D'Agostino RB Jr;Marcovina SM;Liese AD;Zeitler PS;Daniels SR;Dabelea D
• 通讯作者: Dabelea D