Defining Diabetes in Youth

青年糖尿病的定义

• 批准号: 6573180
• 负责人: RICHARD F HAMMAN
• 金额: $ 74.5万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6573180
• 关键词: African American; Hispanic Americans; adolescence (12-20); age difference; body physical characteristic; breast feeding; cardiovascular disorder risk; caucasian American; clinical research; depression; disease /disorder proneness /risk; epidemiology; family genetics; family structure /dynamics; gender difference; gestational diabetes mellitus; human birth weight; human subject; insulin; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; obesity; pancreatic islet function; racial /ethnic difference; socioeconomics

DESCRIPTION (provided by applicant): There is very limited information about the epidemiology of Type 2 diabetes mellitus in youth, though it is believed that the prevalence is increasing rapidly. Risk factors similar to those in adults with Type 2 are thought to be important, (e.g., obesity, insulin resistance, diet, physical activity, positive family history), however, there are no reliable epidemiological studies of these risk factors in youth with type 2 diabetes using appropriate controls. In addition, risk factors such as low birth weight lack of breast-feeding, maternal diabetes during pregnancy and family dysfunction and depressive symptoms have received little epidemiological study in populations other than American Indians. This application addresses the lack of such studies. The Defining Diabetes in Youth (DDY) project will focus on type 2 diabetes in youth aged 10-19, drawing upon the CDC funded SEARCH diabetes registry project in Colorado and South Carolina. The SEARCH project will ascertain all cases of diabetes in youth, collect immunologic, clinical, and metabolic information, and classify cases as Type 1 or 2 diabetes. DDY will only have to recruit appropriate controls aged 10-19 from three ethnic backgrounds including African Americans (AA), Hispanics (H), and non-Hispanic whites (NHW) to test specific etiologic hypotheses in the cases classified by SEARCH as Type 2 diabetes. It will also explore cardiovascular risk factor differences in youth with Type 2 diabetes and controls, and will evaluate insulin resistance and secretion differences among controls by level of obesity and other factors. The primary design is a case-control study, through which risk factors for diabetes, selected complications and CVD risk factors will be evaluated. The current application is an approved SEARCH ancillary study. Collaborating investigators bring expertise in multiple areas relevant to diabetes in youth, and experience in large epidemiological studies of diabetes (both type 1 and 2) in minority populations. Given the low prevalence of Type 2 in Youth, DDY is an efficient design, since case ascertainment and typing will be conducted by SEARCH, and only control recruitment, addition of new measures, and analysis are requested. The biostatistical analysis, data management and central laboratory will be the same as used in SEARCH.

描述（由申请人提供）：关于年轻人中2型糖尿病的流行病学的信息非常有限，尽管人们认为患病率正在迅速增加。危险因素与2型成年人相似的危险因素被认为很重要（例如，肥胖，胰岛素抵抗，饮食，体育锻炼，积极的家族史），但是，在类型的年轻人中，这些危险因素没有可靠的流行病学研究使用适当的控件使用2个糖尿病。此外，诸如低出生体重缺乏母乳喂养，怀孕期间的母亲糖尿病以及家庭功能障碍和抑郁症状等危险因素几乎没有接受美国印第安人以外的其他人群。该应用程序解决了缺乏此类研究。 年轻人（DDY）项目定义的糖尿病将集中在10-19岁青年的2型糖尿病上，借鉴了科罗拉多州和南卡罗来纳州的CDC资助的搜索糖尿病注册机构项目。搜索项目将确定青年中的所有糖尿病病例，收集免疫，临床和代谢信息，并将病例归类为1型或2型糖尿病。 DDY只需要从包括非洲裔美国人（AA），西班牙裔（H）和非西班牙裔白人（NHW）在内的三个种族背景中招募适当的10-19岁的对照，以测试通过搜索2型分类为2类的病因学假设糖尿病。它还将探索2型糖尿病和控制的青年中的心血管危险因素差异，并将评估对控制之间胰岛素抵抗和分泌差异，按肥胖和其他因素水平来评估。主要设计是一项病例对照研究，通过该研究，将评估糖尿病，选定并发症和CVD风险因素的风险因素。当前的应用程序是一项批准的辅助研究。 合作研究人员在与糖尿病有关的多个领域中提供了专业知识，并在少数民族人群中对糖尿病的大型流行病学研究（均为1型和2型）的经验。鉴于年轻人2型的患病率较低，DDY是一种有效的设计，因为案例确定和键入将通过搜索进行，并且只要求控制招聘，增加新措施和分析。生物统计分析，数据管理和中央实验室将与搜索中的使用相同。