A Multidimensional Neuroimaging Investigation of Posttraumatic Stress in Humans

人类创伤后应激的多维神经影像研究

基本信息

批准号：
9467954
负责人：
Nathaniel G Harnett
金额：
$ 3.86万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-28 至 2018-09-27
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9467954
关键词：
Acute Address Area Award Behavioral Biochemical Biochemistry Brain Clinical Research Collaborations Competence Data Collection Development Diagnostic Specificity Distress Drops Educational process of instructing Emotional Ensure Faculty Functional Magnetic Resonance Imaging Goals Human Individual Individual Differences Institutes Investigation Manuscripts Mediating Mentors Mentorship Methods Neurobiology Neurology Neurosciences Research Phase Post-Traumatic Stress Disorders Predisposition Prevention Privatization Procedures Program Development Psychiatry Psychology Public Health Publications Research Research Personnel Research Project Grants Research Training Self Efficacy Severities Stress Structure Students Techniques Technology Training Training Support Translating Trauma Treatment outcome Underrepresented Minority United States United States National Institutes of Health Work Writing conditioned fear effective intervention experience improved innovation insight intervention program member multimodality neuroimaging neuroregulation novel post-doctoral training post-traumatic stress pre-doctoral programs skills statistics stress disorder tractography traumatic event treatment program underrepresented minority student white matter

项目摘要

PROJECT SUMMARY/ABSTRACT Neuroscientists from underrepresents backgrounds drop out of predoctoral programs at a significantly higher rate than traditional students. This attrition has a detrimental impact on the scientific field as decreases in diversity diminish the range of techniques, perspectives, and potential for innovative collaborations necessary for scientific discovery. Therefore, the objective of the current proposal is to institute a robust individual research training plan to increase the diversity of the neuroscientific workforce. Specifically, a structured and formal training plan will supplement the applicant’s intensive dissertation research on the neurobiology of post-traumatic stress. Each year 25 million people in the United States suffer a traumatic event, however only about 30% of these individuals develop Post-Traumatic Stress Disorder (PTSD). Thus, there is individual variability in stress susceptibility, which may be due to variability in the neurobiology of post- traumatic stress. Currently, the acute effect (i.e. within a month) of post-traumatic stress on the brain is not well understood. Determining the impact of trauma-induced distress on brain structure, function, and biochemistry is critical for a thorough understanding of stress disorder that can then be translated into effective intervention and treatment programs. The applicant’s research during the F99 phase will utilize human neuroimaging technology with healthy and traumatized individuals to investigate how brain function, structure, and biochemistry vary with post-traumatic stress severity. The proposed research project will be completed in conjunction with a formal training plan. Specifically, training during the F99 phase will focus on developing competency in 1) MR methods/techniques, 2) scientific writing/presentation, and 3) mentorship skills. The applicant’s mentorship team includes established faculty members to provide formal training in these areas, as well as direct mentorship regarding particularly sensitive issues (e.g., self-efficacy, navigating professional interactions, etc.) for underrepresented minority scholars. The mentorship team is scientifically diverse drawing from faculty within the Departments of Psychology (Dr. David C. Knight – Primary Mentor), Neurology (Dr. Jerzy Szaflarski), Psychiatry and Behavioral Neurobiology (Dr. Adrienne Lahti), and Neurobiology (Dr. Farah Lubin). As part of the K00 phase, the applicant intends to translate the findings from the F99 phase into clinical research using novel neuroimaging and neuromodulatory techniques. The research direction is intended to focus on 1) prediction of stress disorder following trauma via advanced/integrated neuroimaging techniques and 2) prevention of stress disorder development through neuromodulatory techniques. Training during the K00 phase will focus on developing competency in 1) novel research approaches, 2) research program development and management, and 3) teaching skills. The current application will guide the applicant through the academic pipeline and allow him to achieve his goal of becoming an independent neuroscientist.

项目概要/摘要来自代表性不足背景的神经科学家从博士前课程中退出的比例显着这种流失率比传统学生更高，因为这种流失对科学领域产生了不利影响。多样性减少了技术、观点和创新合作潜力的范围因此，当前提案的目标是建立一个强有力的机制。个人研究培训计划，以增加神经科学劳动力的多样性。结构化和正式的培训计划将补充申请人的深入论文研究创伤后应激的神经生物学。美国每年有 2500 万人遭受创伤。然而，这些人中只有约 30% 患有创伤后应激障碍 (PTSD)。应激敏感性存在个体差异，这可能是由于应激后神经生物学的差异所致。目前，创伤后应激对大脑的急性影响（即一个月内）并不明显。了解创伤引起的痛苦对大脑结构、功能和生物化学的影响。对于彻底了解应激障碍至关重要，然后将其转化为有效的干预措施申请人在 F99 阶段的研究将利用人类神经影像学。技术与健康和受创伤的个体一起研究大脑的功能、结构和生物化学随创伤后应激的严重程度而变化。拟议的研究项目将于年内完成。具体而言，F99 阶段的培训将侧重于发展。 1) MR 方法/技术，2) 科学写作/演示，以及 3) 指导技能的能力。申请人的导师团队包括已建立的教职人员，在这些领域提供正式培训，例如以及针对特别敏感问题的直接指导（例如自我效能感、专业指导）互动等），为代表性不足的少数学者提供科学多样化的指导。来自心理学系（David C. Knight 博士 - 主要导师）、神经学系（Dr. David C. Knight）的教师。 Jerzy Szaflarski）、精神病学和行为神经生物学（Adrienne Lahti 博士）和神经生物学（Farah 博士） Lubin）作为K00阶段的一部分，申请人打算将F99阶段的研究结果转化为临床。使用新型神经影像和神经调节技术的研究。重点关注 1) 通过先进/综合神经影像技术预测创伤后应激障碍 2）通过训练期间的神经调节技术预防应激障碍的发展。 K00 阶段将侧重于培养 1) 新颖研究方法、2) 研究项目的能力开发和管理，以及 3) 教学技能当前的申请将指导申请人完成整个过程。学术管道并让他实现成为一名独立神经科学家的目标。