Multimodal characterization of affective visual processing in the early aftermath of trauma

创伤后早期情感视觉处理的多模态特征

基本信息

批准号：
10590116
负责人：
Nathaniel G Harnett
金额：
$ 17.97万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-12-15 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10590116
关键词：
Acute Acute Post Traumatic Stress Disorder Affect Affective Architecture Arousal Association Learning Attention Behavior Behavioral Model Big Data Big Data Methods Boston Brain Chronic Chronic Phase Chronic Post Traumatic Stress Disorder Clinical Clinical assessments Cognitive Complement Computer Models Coupling Data Data Analyses Data Collection Development Diffusion Magnetic Resonance Imaging Dimensions Discrimination Early-life trauma Emotional Environment Exposure to Family Functional Magnetic Resonance Imaging Functional disorder Future Generations Goals Hospitals Image Imaging Techniques Individual Institution Investigation K-Series Research Career Programs Magnetic Resonance Imaging Maps Mediating Memory Mentors Methods Modeling National Institute of Mental Health Negative Valence Neurobiology Neurosciences Neurosciences Research Pathway interactions Perception Population Post-Traumatic Stress Disorders Predisposition Prevention Prevention strategy Procedures Process Psychiatry Public Health Reaction Time Reproducibility Research Research Design Research Domain Criteria Research Personnel Research Project Grants Research Training Resources Rest Risk Risk Factors Sensory Site Standardization Statistical Data Interpretation Stimulus Stream Symptoms System Training Training Programs Trauma United States National Institutes of Health Visual Visual Pathways Visual Perception Visual System Visual attention Work acute stress adverse outcome career clinical training clinical translation cognitive neuroscience cohort conditioning data fusion data management improved individual variation innovation insight large datasets medical schools multimodal data multimodality negative affect neural neural circuit neurobiological mechanism neuroimaging neurophysiology novel predictive modeling preventive intervention programs response skills social stress reactivity stress related disorder stress symptom trauma exposure traumatic event traumatic stress visual processing visual search visual stimulus

项目摘要

PROJECT SUMMARY/ABSTRACT Understanding the neurobiology mediating susceptibility to trauma and stress-related disorders is necessary for future translational efforts to improve treatment and prevention. This Mentored Career Development Award proposal is tailored to facilitate the candidate’s training in multimodal assessment of brain and behavior, in addition to clinical assessment and computational psychiatry approaches, to elucidate the neurobiology of susceptibility to posttraumatic dysfunction. The proposed research training plan will build the candidate’s skills in multidimensional assessment of perceptual (i.e., visual) processing in the early aftermath of trauma, advanced computational modeling of behavioral processes, and ‘big-data’ modeling approaches for fusion of multimodal magnetic resonance imaging (MRI) data. This training is complemented by mentored training in clinical assessment of trauma-related dysfunction and research program management necessary for transition to an independent career as a translational neuroscientist. The completion of the K01 will facilitate the candidate’s transition to an independent investigator capable of developing new neuroscience-based predictive models and preventative strategies to lessen the burden of trauma and stress-related disorders. PTSD is typically conceptualized as a dysfunction of arousal and negative valence systems with the NIH Research Domain Criteria framework. However, new research demonstrates that neural circuitry of affective visual perceptual processing, in particular affective visual processing, may be a significant risk factor for PTSD. Limited work to date has probed affective visual circuitry in the early aftermath of trauma. The proposed research will leverage state-of-the-art MRI data collection and analysis with computational cognitive neuroscience approaches to elucidate impacts of trauma on affective visual processing. The project will thus better characterize an understudied aspect of the RDoC perceptual framework in trauma to integrate visual circuitry variability in both threat-related processes and PTSD-related dysfunction. Previous research in recently traumatized individuals has also not leveraged multimodal data approaches to establish generalizable markers of PTSD susceptibility. This project will address these limitations by focusing on perceptual circuits and by integrating pre-existing large datasets of trauma and PTSD with multimodal data fusion analytics to assess the robustness of observed neurobiological signatures of trauma-related dysfunction vulnerability. Further, the proposal seeks to use standardized, open processing pipelines to enhance reproducibility and replicability of observed findings to promote generalizability. The research training plan will occur at McLean Hospital, the leading psychiatric research hospital of Harvard Medical School. The institution, and academic culture in greater Boston provides an outstanding environment and access to resources for successful competition of this proposed Mentored Career Development Award.

项目概要/摘要了解神经生物学介导对创伤和压力相关疾病的易感性是对于未来改善治疗和预防的转化努力是必要的。发展奖提案是专门为促进候选人的大脑多模式评估培训而量身定制的除了临床评估和计算精神病学方法之外，还通过研究和行为来阐明拟议的研究培训计划将建立创伤后功能障碍易感性的神经生物学。候选人在事后早期对感知（即视觉）处理进行多维评估的技能创伤、行为过程的高级计算模型以及“大数据”建模方法多模态磁共振成像 (MRI) 数据的融合由指导进行补充。创伤相关功能障碍的临床评估和研究项目管理方面的培训 K01 的完成将促进向独立职业转化神经科学家的转变。候选人转变为能够开发新的基于神经科学的预测的独立研究者减轻创伤和压力相关疾病负担的模型和预防策略。 NIH 通常将 PTSD 概念化为唤醒和负价系统功能障碍研究领域标准框架然而，新的研究表明情感的神经回路。视觉感知处理，特别是情感视觉处理，可能是 PTSD 的一个重要危险因素。迄今为止，有限的工作探索了创伤后早期的情感视觉回路。将利用最先进的 MRI 数据收集和分析以及计算认知神经科学因此，该项目将更好地阐明创伤对情感视觉处理的影响。表征创伤中 RDoC 感知框架的一个未充分研究的方面，以整合视觉电路威胁相关过程和 PTSD 相关功能障碍的变异性。先前针对最近遭受创伤的个体的研究也没有利用多模式数据方法建立 PTSD 易感性的通用标记该项目将通过关注来解决这些局限性。感知回路并将现有的创伤和创伤后应激障碍 (PTSD) 大型数据集与多模态数据集成融合分析来评估观察到的创伤相关功能障碍的神经生物学特征的稳健性此外，该提案还寻求使用标准化、开放的处理管道来增强脆弱性。观察结果的可重复性和可复制性，以促进研究培训计划的普遍性。发生在哈佛医学院领先的精神病学研究医院麦克莱恩医院。大波士顿地区的学术文化为学生提供了卓越的环境和资源本次拟议的指导职业发展奖的成功竞争。