Howard University Clinical Research Network for Health Equity

霍华德大学健康公平临床研究网络

• 批准号: 10710201
• 负责人: Mark S. Johnson
• 金额: $ 98.4万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-26 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10710201
• 关键词: Address; Adoption; Affect; African American; African American population; Agreement; Chronic Disease; Clinical Data; Clinical Investigator; Clinical Management; Clinical Practice Guideline; Clinical Research; Clinical Trials; Collaborations; Complex; Data Analytics; Data Science; Development; Disease; Disease Management; Disparity; District of Columbia; Epidemiology; Etiology; Faculty; Funding; Generations; Health Disparities Research; Health Professional; Information Technology; Infrastructure; Institution; Investigation; Knowledge; Low income; Methods; Minority Groups; Mission; Morbidity - disease rate; Outcome; Participant; Patient Care; Patient Recruitments; Patients; Physicians; Pilot Projects; Policies; Population; Preventive care; Preventive service; Principal Investigator; Process; Productivity; Protocols documentation; Recommendation; Research; Research Activity; Research Personnel; Scientific Inquiry; Systems Analysis; Underrepresented Minority; United States Preventative Services Task Force; Universities; University Hospitals; clinical data repository; clinical development; combat; design; effectiveness evaluation; electronic medical record system; evidence base; experience; graduate medical education; health data; health disparity; health disparity populations; health equity; health information technology; improve minority health; improved; informatics infrastructure; inner city; innovation; knowledge translation; mHealth; minority health; minority health disparity; mortality; new technology; predictive modeling; research study; undergraduate medical education

Research Abstract African Americans experience significant disparities in chronic disease morbidity and mortality. Of note, eliminating health disparities requires significant improvement in chronic disease management, which is dependent on the provision and utilization of evidence-based preventive care. The provision of high-quality preventive services to the African Americans is hindered by several things including insufficient evidence which is a consequence of underrepresentation of minority populations in clinical research trials. In fact, United States Preventive Services Task Force (USPSTF) recommendation statements often cite underrepresentation of minorities in clinical trials as a research gap and limitation. This affects the development of clinical practice guidelines that meet the needs of minority populations when the epidemiology of a particular disease is different in minority populations. Not only is there an underrepresentation of minorities as study participants but there is equally severe underrepresentation of African Americans as clinical investigators, which is due in part to underrepresentation of African Americans in the clinical research workforce. Addressing these disparities requires complex systems analysis, development of innovative approaches, generation of scientific evidence, and effective knowledge dissemination. For over 150 years, Howard University has contributed significantly to the African American physician workforce through undergraduate and graduate medical education. In addition, Howard University has advanced minority health through robust research activities and comprehensive patient care to the residents of the District of Columbia and beyond. The adoption of Electronic Medical Record Systems by Howard University Hospital and Howard University Faculty Practice Plan has led to the generation of vast amounts of clinical data about this inner-city urban low-income African American population. To address the challenges, we propose the formation of the Howard University Clinical Research Network (HUCRN) as an addition to the consortium of the RCMI Clinical Research Network for Health Equity (RCMI-CRNHE). This effort will lead to an innovative, productive, and impactful research network for investigation of studies of high importance in minority health and health disparities. The significance of this project is derived from the necessity to study a health disparity affected population, burden of chronic disease, prevalent health disparities, engagement of an underrepresented clinical research workforce. Further we intend to introduce a new application of innovative data science called mHealth. We will develop a mHealth information technology infrastructure, clinical research informatics infrastructure including a clinical data repository, and we will conduct 2 pilot studies to assess the effectiveness of the infrastructure, policies, and processes that have been implemented.

研究摘要 非裔美国人在慢性病发病率和死亡率方面存在显着差异。值得注意的是， 消除健康差距需要显着改善慢性病管理，这 依赖于循证预防性护理的提供和利用。提供高质量的 对非裔美国人的预防服务受到多种因素的阻碍，包括证据不足 是临床研究试验中少数群体代表性不足的结果。事实上，美国 预防服务工作组 (USPSTF) 的建议声明经常提到代表性不足 临床试验中的少数群体是研究的差距和局限性。这影响了临床实践的发展 当特定疾病的流行病学发生变化时满足少数群体需求的指南 少数民族人口则不同。不仅少数族裔作为研究参与者的代表性不足，而且 作为临床研究人员，非洲裔美国人的代表性同样严重不足，部分原因是 临床研究队伍中非裔美国人的代表性不足。解决这些差异 需要复杂的系统分析、创新方法的开发、科学证据的生成， 和有效的知识传播。 150 多年来，霍华德大学为以下领域做出了重大贡献： 通过本科和研究生医学教育培养非裔美国医生队伍。此外， 霍华德大学通过强有力的研究活动和全面的患者研究促进了少数族裔的健康 照顾哥伦比亚特区及其他地区的居民。采用电子病历 霍华德大学医院和霍华德大学教员实践计划的系统导致了这一代 有关内城区低收入非裔美国人群体的大量临床数据。 为了应对挑战，我们建议成立霍华德大学临床研究中心 网络 (HUCRN) 作为 RCMI 健康公平临床研究网络联盟的补充 （RCMI-CRNHE）。这项努力将为以下领域带来一个创新、富有成效和有影响力的研究网络 对少数民族健康和健康差异方面非常重要的研究进行调查。此举的意义 该项目源于研究受健康差距影响的人群、慢性病负担的必要性， 普遍存在的健康差异、代表性不足的临床研究人员的参与。进一步我们打算 介绍一种称为移动医疗的创新数据科学的新应用。我们将开发移动医疗 信息技术基础设施、临床研究信息学基础设施，包括临床数据 存储库，我们将进行两项试点研究，以评估基础设施、政策和 已实施的流程。