Identifying mechanisms of maternal-infant obesity risk transmission: The role of appetite, sleep, and circadian rhythms

确定母婴肥胖风险传播的机制：食欲、睡眠和昼夜节律的作用

基本信息

批准号：
10711067
负责人：
Rachel P. Kolko Conlon
金额：
$ 72.45万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10711067
关键词：
Address Adult Affect Applications Grants Behavior Therapy Behavioral Biological Clocks Birth Body Weight Body mass index Child Childhood Circadian Rhythms Darkness Data Desire for food Development Early identification Eating Ensure Family Feeding Patterns Female Food Health Hour Individual Infant Infant Food Interruption Intervention Life Light Link Longevity Measures Methodology Methods Modeling Mothers National Heart, Lung, and Blood Institute Obesity Outcome Parents Patient Self-Report Pattern Persons Physiological Population Postpartum Period Postpartum Women Pregnancy Pregnant Women Reporting Research Research Personnel Research Priority Research Project Grants Rest Risk Factors Role Running Satiation Science Sleep Sleep disturbances Solid Standardization Strategic Planning Strategic vision System Third Pregnancy Trimester Time United States National Institutes of Health Weight Weight Gain Woman actigraphy approach behavior avoidance behavior behavior change cardiometabolism circadian critical period design effective intervention feeding food avoidance infancy infant adiposity innovation intergenerational modifiable risk novel novel strategies obesity risk obesity treatment pregnant prepregnancy pressure prevent programs prospective rapid infant weight gain rapid weight gain recruit sucking therapeutic target therapy development trait transmission process

项目摘要

Project Summary/Abstract Weight gain patterns during the first year of life are a critical risk factor for long-term cardiometabolic health from infancy through adulthood. Infant obesity risk is influenced by appetitive traits in the first 3 months. These appetitive traits, food responsiveness (FR) and satiety responsiveness (SR), reflect food approach and avoidance behaviors, respectively. However, little is known about factors that affect FR and SR development during infancy, which may inform novel, effective behavioral interventions for obesity risk. Emerging data indicate that sleep and circadian rhythms are related to appetite in children and adults, although little is known about how sleep and circadian rhythms are associated with appetite development in infants. We posit the novel hypothesis that infant sleep/circadian rhythm patterns affect infants’ appetite, and together, they impact infants’ obesity risk. We also posit that the degree of synchronization between maternal and infant circadian rhythms further affects infant appetite development and obesity risk. In the proposed study, pregnant individuals (N=230, body mass index ≥18.5 kg/m2) will be recruited in their third trimester. We acknowledge that not all who give birth identify as women or females. We use the terms "pregnant women," "postpartum women," “maternal,” and "mothers" to refer to all birthing people throughout this application. Maternal-infant sleep and circadian rhythms (focused on rest-activity rhythms and nighttime feeding), along with infant appetite and weight, will be assessed via objective and subjective methods at 1-, 3-, 6-, and 12-months after birth. Thus, to identify potentially modifiable influences on infant weight trajectory, the specific aims are to: (1) determine the concurrent and predictive effects of infant sleep/circadian rhythms on infant appetite development in the first 6 months of life; (2) identify the combined effects of early infant appetite and disrupted sleep/circadian rhythms on rapid infant weight gain in the first 6 months and infant weight outcomes at 12-months; and (3) explore the role of maternal-infant synchronization of rest-activity rhythms in the models of infant sleep/circadian rhythms and appetite predicting infant weight. This proposal addresses compelling questions about sleep, circadian rhythms, and obesity identified in the NHLBI Strategic Vision and NIH Strategic Plan. Notably, in alignment with the Katz Early Stage Investigator Research Grant Program, this proposal involves innovative changes in the PI’s research direction: (1) new population (moving from mothers to infants); (2) new methods (moving from self-report to objective assessment and dyadic metrics); and (3) new potential therapeutic targets (moving from eating-related targets to sleep/circadian rhythms & maternal-infant synchronization). The PI and investigative team have the content and methodological expertise that will ensure successful conduct of the proposed research. In line with the NIH Science of Behavior Change intervention development pipeline, data from this study will inform the targets and timing of maternal-infant behavioral interventions guided by circadian rhythms and infant appetite development to reduce obesity risk and promote intergenerational cardiometabolic health.

项目摘要/摘要生命第一年的体重增加模式是长期心脏代谢健康的关键危险因素从婴儿期到成年。婴儿肥胖风险在头三个月内受到食欲特征的影响。这些食欲的特征，食物反应能力（FR）和饱腹感反应能力（SR），反映食物方法和避免行为。但是，对影响FR和SR发展的因素知之甚少在婴儿期，这可能会为肥胖风险提供新颖的有效行为干预措施。新兴数据表明睡眠和昼夜节律与儿童和成人的食欲有关，尽管知之甚少关于睡眠和昼夜节律如何与婴儿的食欲发展有关。我们定位小说假设婴儿睡眠/昼夜节律模式会影响婴儿的食欲，并且会影响婴儿的食欲。肥胖风险。我们还认为，母亲和婴儿昼夜节律之间的同步程度进一步影响婴儿食欲发展和肥胖风险。在拟议的研究中，怀孕的个体（n = 230，体重指数≥18.5kg/m2）将在其三个月中招募。我们承认并非所有给出妇女或女性的诞生鉴定。我们使用“孕妇”，“产后妇女”一词在整个申请中，“母亲”和“母亲”指的是所有生日的人。孕产妇的睡眠和昼夜节律（专注于静息节奏和夜间喂养），婴儿的胃口和体重将在出生后1-，3-，6，6和12个月的客观和主观方法进行评估。那是确定对婴儿体重轨迹的潜在可修改影响，具体目的是：（1）确定婴儿睡眠/昼夜节律对婴儿食欲发育的同时和预测作用生命的月份；（2）确定早期婴儿食欲和破坏睡眠/昼夜节律的综合作用在最初6个月内婴儿体重快速增加，婴儿体重结局在12个月时的体重预后；（3）探索在婴儿睡眠/昼夜节律模型中，母体侵入性节奏同步的作用和胃口可预测婴儿体重。该提议解决了有关睡眠的令人信服的问题，昼夜节律 NHLBI战略愿景和NIH战略计划中确定的节奏和肥胖。值得注意的是，与卡茨早期研究员研究赠款计划，该提案涉及创新的变化 PI的研究方向：（1）新人群（从母亲转移到婴儿）；（2）新方法（从对客观评估和二元指标的自我报告）；（3）新的潜在治疗靶标（从与饮食相关的目标，用于睡眠/昼夜节律和孕产妇同步）。 PI和调查团队具有内容和方法论专业知识，可以确保成功的行为研究。与NIH的行为变化干预开发管道一致，从此数据研究将告知昼夜节律指导的产妇行为干预的目标和时间和婴儿的食欲发展，以降低观察风险并促进代代代谢健康。