Identifying mechanisms of maternal-infant obesity risk transmission: The role of appetite, sleep, and circadian rhythms

确定母婴肥胖风险传播的机制：食欲、睡眠和昼夜节律的作用

• 批准号: 10711067
• 负责人: Rachel P. Kolko Conlon
• 金额: $ 72.45万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711067
• 关键词: Address; Adult; Affect; Applications Grants; Behavior Therapy; Behavioral; Biological Clocks; Birth; Body Weight; Body mass index; Child; Childhood; Circadian Rhythms; Darkness; Data; Desire for food; Development; Early identification; Eating; Ensure; Family; Feeding Patterns; Female; Food; Health; Hour; Individual; Infant; Infant Food; Interruption; Intervention; Life; Light; Link; Longevity; Measures; Methodology; Methods; Modeling; Mothers; National Heart, Lung, and Blood Institute; Obesity; Outcome; Parents; Patient Self-Report; Pattern; Persons; Physiological; Population; Postpartum Period; Postpartum Women; Pregnancy; Pregnant Women; Reporting; Research; Research Personnel; Research Priority; Research Project Grants; Rest; Risk Factors; Role; Running; Satiation; Science; Sleep; Sleep disturbances; Solid; Standardization; Strategic Planning; Strategic vision; System; Third Pregnancy Trimester; Time; United States National Institutes of Health; Weight; Weight Gain; Woman; actigraphy; approach behavior; avoidance behavior; behavior change; cardiometabolism; circadian; critical period; design; effective intervention; feeding; food avoidance; infancy; infant adiposity; innovation; intergenerational; modifiable risk; novel; novel strategies; obesity risk; obesity treatment; pregnant; prepregnancy; pressure; prevent; programs; prospective; rapid infant weight gain; rapid weight gain; recruit; sucking; therapeutic target; therapy development; trait; transmission process

Project Summary/Abstract Weight gain patterns during the first year of life are a critical risk factor for long-term cardiometabolic health from infancy through adulthood. Infant obesity risk is influenced by appetitive traits in the first 3 months. These appetitive traits, food responsiveness (FR) and satiety responsiveness (SR), reflect food approach and avoidance behaviors, respectively. However, little is known about factors that affect FR and SR development during infancy, which may inform novel, effective behavioral interventions for obesity risk. Emerging data indicate that sleep and circadian rhythms are related to appetite in children and adults, although little is known about how sleep and circadian rhythms are associated with appetite development in infants. We posit the novel hypothesis that infant sleep/circadian rhythm patterns affect infants’ appetite, and together, they impact infants’ obesity risk. We also posit that the degree of synchronization between maternal and infant circadian rhythms further affects infant appetite development and obesity risk. In the proposed study, pregnant individuals (N=230, body mass index ≥18.5 kg/m2) will be recruited in their third trimester. We acknowledge that not all who give birth identify as women or females. We use the terms "pregnant women," "postpartum women," “maternal,” and "mothers" to refer to all birthing people throughout this application. Maternal-infant sleep and circadian rhythms (focused on rest-activity rhythms and nighttime feeding), along with infant appetite and weight, will be assessed via objective and subjective methods at 1-, 3-, 6-, and 12-months after birth. Thus, to identify potentially modifiable influences on infant weight trajectory, the specific aims are to: (1) determine the concurrent and predictive effects of infant sleep/circadian rhythms on infant appetite development in the first 6 months of life; (2) identify the combined effects of early infant appetite and disrupted sleep/circadian rhythms on rapid infant weight gain in the first 6 months and infant weight outcomes at 12-months; and (3) explore the role of maternal-infant synchronization of rest-activity rhythms in the models of infant sleep/circadian rhythms and appetite predicting infant weight. This proposal addresses compelling questions about sleep, circadian rhythms, and obesity identified in the NHLBI Strategic Vision and NIH Strategic Plan. Notably, in alignment with the Katz Early Stage Investigator Research Grant Program, this proposal involves innovative changes in the PI’s research direction: (1) new population (moving from mothers to infants); (2) new methods (moving from self-report to objective assessment and dyadic metrics); and (3) new potential therapeutic targets (moving from eating-related targets to sleep/circadian rhythms & maternal-infant synchronization). The PI and investigative team have the content and methodological expertise that will ensure successful conduct of the proposed research. In line with the NIH Science of Behavior Change intervention development pipeline, data from this study will inform the targets and timing of maternal-infant behavioral interventions guided by circadian rhythms and infant appetite development to reduce obesity risk and promote intergenerational cardiometabolic health.

项目摘要/摘要 生命第一年的体重增加模式是长期心脏代谢健康的关键危险因素 从婴儿期到婴儿肥胖风险。 食欲特征，食物球（FR）和饱腹感（SR），反映食物方法和 避免行为，尊重者。 在婴儿期，这可能会为新颖的行为干预风险提供信息。 表明睡眠和昼夜节律与在cildren和成人的食欲中胃口有关 关于睡眠和昼夜节律如何与婴儿的食欲发展有关。 假设婴儿睡眠/昼夜节律模式会影响“食欲，并且会影响婴儿” 肥胖风险。 进一步影响婴儿的食欲发展和肥胖风险。 （n = 230，体重指数≥18.5kg/m2）将在他们的第三个月中招募。 分娩是妇女或女性的人。 “母亲”和“母亲”在整个申请中指代所有分娩的人 昼夜节律（专注于休息性的节奏和夜间喂养），婴儿的食欲和 重量将通过客观和主观方法进行评估，以便在出生后，3个月和12个月 确定对婴儿体重轨迹的潜在可修改影响，具体目的是：（1）确定您 婴儿睡眠/昼夜节律对婴儿食欲发展的同时和预测作用6 生命（2）确定婴儿早期食欲和昼夜节律的综合作用 在最初的6个月中，婴儿体重快速增加，婴儿体重的结局在12个月时；（3）探索您 在婴儿睡眠/昼夜节律模型中，母体侵入性节奏同步的作用 预测婴儿体重的食欲。 在NHLBI战略愿景和NIH战略计划中确定的节奏和肥胖。 Katz早期研究员研究赠款计划，该提案的参与创新的变化 PI的研究方向：（1）新人群（从母亲到婴儿）； 对客观评估和二元指标的自我报告；（3） 与饮食相关的靶标/昼夜节律和孕妇同步的目标。 团队具有内容和方法论专业知识，可以确保拟议的成功行为 与Nihvior变更变更变更变更变更变更变更变更变更的研究 研究将告知由昼夜节律指导的产妇干扰的目标和时间 和婴儿的食欲发展，以降低肥胖肥胖风险并促进国际心脏代谢健康。