Comunidades Positivas and Enhanced Partner Therapy in Peru

秘鲁的 Comunidades Positivas 和强化伴侣治疗

• 批准号: 7163930
• 负责人: Thomas J. Coates
• 金额: $ 57万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-28 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7163930
• 关键词: AIDS education /prevention; HIV infections; Peru; antiinfective agents; behavior therapy; behavioral /social science research tag; clinical research; combination therapy; communicable disease transmission; community; condoms; high risk behavior /lifestyle; homosexuals; human subject; human therapy evaluation; locus of control; longitudinal human study; male; microorganism disease chemotherapy; self help; sex partner; sexually transmitted diseases

DESCRIPTION (provided by applicant): We propose a factorial-design trial that simultaneously tests two interventions-one behavioral and one biomedical-to prevent HIV and STI (sexually transmitted infection) transmission in HSH ("hombres que tiene sexo con hombres"? Spanish for "men who have sex with men") in Peru. The behavioral intervention, entitled "Comunidades Positives," is based on a combination of social-action theory and diffusion of innovation, and is designed to reduce the frequency of unprotected sex with non-primary partners. The biomedical intervention will test the effectiveness of enhanced partner therapy for incident STIs, which involves providing presumptive therapy for certain bacterial and viral STIs to sexual partners. This intervention is designed to reduce the rate of re-infection and therefore, incident STIs. A total of 24 barrios with approximately 27 HIV-positive and/or STI-positive HSH in each barrio will be randomized to one of four cells, each cell corresponding to a combination of each of the two interventions, for a total of 648 subjects. The intervention will last 18 months and will be conducted in three coastal cities in Peru: Trujillo and Chiclayo in the north, and Lima, the capital. Outcomes will include incident STIs (HIV, HSV-2, syphilis, gonorrhea and Chlamydia) as well as unprotected intercourse. We will also model HIV infections averted based on sexual risk reduction and STIs treated and prevented. An expert, multidisciplinary team will conduct this trial, taking advantage of seven years of productive collaborative experience working on STI and HIV prevention in Peru. A substantial knowledge base, human resources, a collaborative network, and infrastructure are available for the trial. In addition, potential field sites and study participants are already involved in existing field trials.

描述（由申请人提供）：我们提出了一项阶乘设计试验，同时测试了两种干预措施 - 一项行为和一种生物医学预防HSH中的HIV和STI和STI（性传播感染）在HSH中的传播（“ Hombres que tiene que tiene que tiene sexo con hombres”？西班牙人？行为干预措施为“共同的阳性”，是基于社会行动理论和创新扩散的结合，旨在减少与非主要伙伴的无保护性别的频率。生物医学干预措施将测试增强伴侣治疗的事件性传播感染的有效性，该疗法涉及为性伴侣提供某些细菌和病毒性传播疾病的推定治疗。该干预措施旨在降低重新感染的速度，因此是事件性传播感染。在每个Barrio中，总共有24个HIV阳性和/或STI阳性HSH的24个Barrios将随机分为四个细胞之一，每个细胞对应于两种干预措施中的每个细胞，总共648位受试者。干预措施将持续18个月，并将在秘鲁的三个沿海城市进行：Trujillo和Chiclayo北部以及首都利马。结果将包括事件性传播感染（HIV，HSV-2，梅毒，淋病和衣原体）以及未受保护的性交。我们还将根据减少性风险和受到治疗和预防的性传播感染对HIV感染进行建模。专家，多学科团队将利用七年的生产性协作经验，从事秘鲁的STI和HIV预防。可供试用的实质性知识库，人力资源，协作网络和基础架构。此外，潜在的现场站点和研究参与者已经参与了现有的现场试验。