Pharmacology of Lifespan Extension

延长寿命的药理学

基本信息

批准号：
9521330
负责人：
Julie Kay Andersen
金额：
$ 19.4万
依托单位：
BUCK INSTITUTE FOR RESEARCH ON AGING
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-15 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9521330
关键词：
Age of Onset Aging Animal Model Biochemical Caenorhabditis Caenorhabditis elegans Cell Line Chemicals Cholecalciferol Chronic Disease Clinical Research Clinical Trials Communities Development Disease Dose Drug Modelings Elderly Endoplasmic Reticulum Exhibits Functional disorder Future Genetic Health Homeostasis Incidence Intervention Lead Link Longevity Longevity Pathway Mammalian Cell Mammals Modeling Natural Products Nematoda Neurodegenerative Disorders Pathology Pathway interactions Pharmaceutical Preparations Pharmacology Phenotype Play Population Prevention Preventive therapy Proteins Public Health Research Role Secosteroids Series Structure Technology Testing Vitamin D Vitamin D Deficiency Work age related amyloid formation compound 30 drug discovery high throughput screening improved novel pre-clinical pre-clinical research prevent protein structure proteostasis public health relevance response small molecule small molecule libraries successful intervention therapy outcome translational study

项目摘要

DESCRIPTION (provided by applicant): We have discovered a series of chemical compounds that delay the onset of age-related pathology and extend lifespan. These compounds were identified in focused chemical screens and high throughput screens of both synthetic compounds and natural products. Here we propose to identify the mechanism of lifespan extension with a focus on vitamin D which we have shown maintains protein homeostasis and extends lifespan in C. elegans. This will uncover novel mechanisms for interventions in aging and age-related disease.

描述（由申请人提供）：我们发现了一系列化合物，可以延缓与年龄相关的病理的发生并延长寿命。这些化合物是在合成化合物和天然产物的重点化学筛选和高通量筛选中鉴定的。在这里，我们建议重点关注维生素 D 来确定延长寿命的机制，我们已证明维生素 D 可以维持秀丽隐杆线虫的蛋白质稳态并延长寿命。这将揭示干预衰老和年龄相关疾病的新机制。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

锌水平通过多种长寿途径调节秀丽隐杆线虫的寿命。

DOI：
发表时间：
2016
期刊：
影响因子：
3.7
作者：
Kumar, Jitendra;Barhydt, Tracy;Awasthi, Anjali;Lithgow, Gordon J;Killilea, David W;Kapahi, Pankaj
通讯作者：
Kapahi, Pankaj

Kavain suppresses human Aβ-induced paralysis in C. elegans.

Kavain 抑制人 Aβ 诱导的线虫麻痹。

DOI：
发表时间：
2020-05-21
期刊：
影响因子：
0
作者：
Chamoli, Manish;Chinta, Shankar J;Andersen, Julie K;Lithgow, Gordon J
通讯作者：
Lithgow, Gordon J

Iron promotes protein insolubility and aging in C. elegans.

铁会促进秀丽隐杆线虫的蛋白质不溶和衰老。

DOI：
发表时间：
2014-11
期刊：
影响因子：
0
作者：
Klang, Ida M;Schilling, Birgit;Sorensen, Dylan J;Sahu, Alexandria K;Kapahi, Pankaj;Andersen, Julie K;Swoboda, Peter;Killilea, David W;Gibson, Bradford W;Lithgow, Gordon J
通讯作者：
Lithgow, Gordon J

Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans.

铝暴露破坏了秀丽隐杆线虫的元素稳态。