NSABP Biological Specimen Banks

NSABP 生物样本库

• 批准号: 7610987
• 负责人: NORMAN WOLMARK
• 金额: $ 122.52万
• 依托单位: NSABP FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-27 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610987
• 关键词: Arts; Back; Biological Specimen Banks; Breast; Cancer Patient; Clinical; Clinical Treatment; Clinical Trials; Collaborations; Colon Carcinoma; Colorectal Cancer; Communities; Confidentiality of Patient Information; Controlled Clinical Trials; Custom; Data; Development; Enrollment; Funding; Goals; Human; Improve Access; Laboratory Finding; Life; Link; Malignant Neoplasms; Methodology; Mission; Modality; Molecular Profiling; National Surgical Adjuvant Breast and Bowel Project; Organ; Outcome; Paraffin; Patients; Personal Satisfaction; Phase III Clinical Trials; Policies; Process; Qualifying; Recurrence; Research Personnel; Resource Development; Resources; Science; Specimen; Specimen Handling; System; Therapeutic; Tissue Banking; Tissue Banks; Tissue Microarray; Translational Research; Work; base; improved; laboratory facility; prognostic; response; success; therapeutic target

DESCRIPTION (provided by applicant): The National Surgical Adjuvant Breast and Bowel Project (NSABP) is an NCI-funded, organ-specific multicenter cooperative trials group whose main goal is to conduct Phase III clinical trials in patients with primary breast and colorectal cancer. The NSABP Human Specimen Bank collects, processes, stores and provides access to high quality specimens obtained from patients entered into NSABP trials. These specimens are carefully linked to the patient's clinical, treatment, recurrence, and outcome data while fully protecting the confidentiality of patients. The scientific aim of the NSABP Human Specimen Bank is to support translational research by providing open access to these well-used annotated specimens in order to facilitate the development of prognostic and predictive markers that can be used to custom-tailor treatment of breast and cotorectal cancer. Specimens from the Bank may also aid in the development of molecular signatures, identification of therapeutic targets, and other important transitional studies. With a Tissue Bank of paraffin blocks from more than 40,000 cases, some dating back to 1971, with the addition of 3,500 cases or more each year, along with a new initiative to collect specimens in RNAlater(r) to support RNA-based studies, the NSABP is certainly able to deliver on that promise. In an effort to further improve access to the NSABP Human Specimen Bank, tissue microarrays (TMAs) from key trials in both breast and colon cancers are being offered to the general scientific community in collaboration with the Resources Development Branch (RDB) of the NCI. The NSABP will also work with the Group Banking Committee to develop policies relating to human specimen banking in NCI-supported cancer clinical trials. Continued support of these relevant, important activities is essential for the well-being of cancer patients and is critical to the success of both the NSABP's and the NCI's missions.

描述（由申请人提供）： 国家手术辅助乳房和肠道项目（NSABP）是NCI资助的，特定器官特定的多中心合作试验组，其主要目标是对原发性乳腺癌和结肠癌患者进行III期临床试验。 NSABP人类标本库收集，工艺，商店并提供从进入NSABP试验的患者获得的高质量标本的访问权限。这些标本仔细地与患者的临床，治疗，复发和结果数据相关联，同时充分保护患者的机密性。 NSABP人类标本库的科学目的是通过提供对这些良好的注释标本的开放访问来支持翻译研究，以促进可用于乳腺癌和乳腺直肠癌的预后和预测标记的发展。银行的标本还可以有助于发展分子特征，治疗靶标的识别以及其他重要的过渡研究。有40,000多个病例的石蜡块组织库，其中一些可以追溯到1971年，每年增加3500例或更多病例，以及一项新的计划，以在Rnalater（R）中收集标本（R）以支持基于RNA的研究，NSABP肯定能够兑现这一承诺。 为了进一步改善对NSABP人类标本库的访问，正在向乳腺癌和结肠癌的主要试验进行组织微阵列（TMA），并与NCI的资源开发分支（RDB）合作，向一般科学界提供了。 NSABP还将与小组银行委员会合作，制定与NCI支持的癌症临床试验中的人类标本银行有关的政策。 持续支持这些相关的重要活动对于癌症患者的福祉至关重要，对于NSABP和NCI任务的成功至关重要。