Instrument development & fabrication for vision research

仪器开发

• 批准号: 6795629
• 负责人: MICHAEL E. GOLDBERG
• 金额: $ 36.73万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6795629
• 关键词: biomedical equipment; biomedical resource; clinical research; computers; neurosciences; vision

DESCRIPTION (provided by applicant): The objective of this proposal is to enhance the research capabilities and collaborative efforts of the vision researchers at the Columbia University Medical Center. State-of-the-art vision research often requires the custom fabrication of mechanical instruments to support the research. Support is requested for a single module to renovate and support the machine shop in the Harkness Eye Institute at Columbia University, to be shared primarily between the Department of Ophthalmology and the Mahoney Center for Brain and Behavior. The module will have 10 users, 7 of whom have NEI-funded RO1 grants, and 3 of whom perform research in the area of visual systems neuroscience on grants funded by the NIMH. All of the investigators are also mentors on an NEI-funded training grant. The current systems projects include studies of the neurophysiology and psychophysics of spatial vision, visual attention, early cortical processing, visual emotional association, and visual motion; the cellular and molecular projects include studies of fluid transport across corneal epithelium, retinal axon guidance, ocular wound healing, and the impact of the lipofuscin fluorophores on retinal pigmented epithelial cell function and viability. All of these projects require the development and fabrication of devices primarily designed for a given project. A great number of these can, when perfected, be shared among a number of projects. Examples of such devices include custom-made nanoliter injection devices, recording chambers, multiple-microdrive platforms, dual recording-iontophoretic devices, illumination devices, and recording gdds. The PI has extensive experience collaborating with machinists, and several of the devices in whose development he participated have been marketed commercially. Currently the Department of Ophthalmology has a fully-equipped machine shop the machines of which are all fine old Bridgeport and Hardinge manual machines. This proposal is to upgrade the machine shop, with a computer-controlled lathe and a computer-controlled milling machine, and to support the salary of the machinist who was hired in June, 2003, using university startup funds. The availability of an in-house professionally certified machinist will significantly speed the process of design and fabrication of custom instruments. The use of computer controlled machine tools will facilitate duplication of instruments usable in multiple laboratories.

描述（由申请人提供）：该提案的目的是增强哥伦比亚大学医学中心远见研究人员的研究能力和协作努力。 最先进的视觉研究通常需要定制的机械仪器来支持研究。要求提供一个单个模块，以翻新和支持哥伦比亚大学Harkness Eye Institute的机械车间，主要在眼科系和Mahoney大脑与行为中心之间进行分享。 该模块将有10个用户，其中7个具有NEI资助的RO1赠款，其中3个用户在NIMH资助的赠款方面进行了视觉系统神经科学领域的研究。所有调查人员也是由Nei资助的培训补助金获得的导师。当前的系统项目包括神经生理学的研究 以及空间视觉，视觉注意力，早期皮质处理，视觉情感关联和视觉运动的心理物理学；细胞和分子项目包括研究跨角膜上皮的液体转运，视网膜轴突引导，眼伤愈合以及脂肪霉素荧光团对视网膜色素上皮细胞功能和生存能力的影响。所有这些项目都需要开发和制造主要是为给定项目设计的设备。其中很多可以在许多项目之间共享。此类设备的示例包括定制的纳米仪注入设备，录制室，多种微型平台，双记录 - 离子电图设备，照明设备和记录GDD。 PI具有与机械师合作的丰富经验，并且他参与其开发的一些设备已在商业上销售。 目前，眼科部门设有一家设备齐全的机器，其机器都是旧的旧布里奇波特和哈丁手动机器。该建议是通过计算机控制的车床和计算机控制的铣床来升级机械车间，并支持2003年6月使用大学初创企业基金雇用的机械师的工资。内部专业认证的机械师的可用性将大大加快定制仪器的设计和制造过程。 使用计算机控制的机床将有助于在多个实验室中使用的仪器的复制。