Caffeine and Glucose Regulation

咖啡因和血糖调节

• 批准号: 6768965
• 负责人: James D. Lane
• 金额: $ 36.19万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6768965
• 关键词: blood glucose; body physical activity; caffeine; carbohydrates; cardiovascular disorder risk; clinical research; diabetes risk; drug related diabetes mellitus; glucose metabolism; glucose tolerance; human subject; hyperglycemia; hyperinsulinism; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; patient monitoring device; phlebotomy

DESCRIPTION (provided by applicant): Caffeine has widespread effects in the 90 percent of US adults who consume it daily. Recent research in our laboratory indicates that caffeine has disruptive effects on glucose metabolism that may seriously impair glycemic control in type 2 diabetes and aggravate insulin resistance in pre-diabetic individuals. We propose 4 studies to determine the nature and extent of caffeine's effects and their potential importance to diabetes. A replication and extension of our preliminary study will examine the effects of a controlled dose of caffeine on fasting glucose and insulin and responses to the oral glucose tolerance test (OGTT) to determine whether caffeine aggravates hyperglycemic and hyperinsulinemic responses in type 2 diabetes patients. We will test a variety of clinical and physiological factors that could account for individual differences in caffeine's effects, to identify patients at greatest risk of impairment and to elucidate potential mechanisms of action. A similar study will determine caffeine's effects on glucose metabolism in subjects who are currently "pre-diabetic," but at risk of developing clinical diabetes. Confirming that caffeine increases insulin resistance and may elicit hyperglycemia in this group would establish caffeine as a factor that could aggravate and contribute to the metabolic processes that lead to the development of diabetes in this high-risk group. A third study will extend our laboratory findings into the natural environment and explore the use of continuous glucose monitoring system (CGMS) methodologies to determine the effects of caffeine consumption on blood glucose during normal daily activities. These ambulatory measurements will complement the controlled laboratory studies and establish the ecological importance of these effects. Together these studies will establish a foundation of evidence regarding caffeine's effects on glucose metabolism and their importance to clinical glucose management in type 2 diabetes. This foundation will support later studies of mechanism as well as clinical intervention trials.

描述（由申请人提供）：咖啡因在每天消费的90％的成年人中具有广泛的影响。我们实验室的最新研究表明，咖啡因对葡萄糖代谢具有破坏性作用，可能会严重损害2型糖尿病中血糖控制，并在糖尿病前个体中加剧胰岛素抵抗。我们提出了4项研究，以确定咖啡因作用的性质和程度及其对糖尿病的潜在重要性。我们初步研究的复制和扩展将检查咖啡因剂量对空腹葡萄糖和胰岛素的影响以及对2型糖尿病患者中高葡萄糖和高胰岛素治疗的高糖症和高胰岛素反应是否加重咖啡因的口服葡萄糖耐受性测试（OGTT）的反应。我们将测试各种临床和生理因素，这些因素可以解释咖啡因作用的个体差异，以识别患有最大损害风险并阐明潜在作用机制的患者。 一项类似的研究将确定咖啡因对当前“糖尿病前”但有患临床糖尿病的风险的受试者中葡萄糖代谢的影响。确认咖啡因会增加胰岛素耐药性，并可能引起该组中的高血糖症，这将确立咖啡因是一种可能加重并有助于导致这一高风险群体糖尿病发展的代谢过程的因素。 第三项研究将将我们的实验室发现扩展到自然环境，并探索连续的葡萄糖监测系统（CGMS）方法的使用，以确定咖啡因消耗对正常日常活动中血糖的影响。这些门诊测量将补充受控实验室研究，并确定这些影响的生态重要性。 这些研究将共同​​建立有关咖啡因对葡萄糖代谢的影响及其对2型糖尿病临床葡萄糖管理的重要性的基础。该基础将支持以后的机制研究以及临床干预试验。