Meditation for High Blood Pressure

冥想治疗高血压

• 批准号: 6662494
• 负责人: James D. Lane
• 金额: $ 30.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6662494
• 关键词: alternative medicine; behavior therapy; behavioral /social science research tag; cardiovascular disorder therapy; clinical trials; human subject; human therapy evaluation; hypertension; meditation; patient oriented research; relaxation; stress management

DESCRIPTION (provided by applicant): High blood pressure is a major public health problem that affects nearly 25 percent of adults in the United States and contributes to increased risks of morbidity and mortality via cardiovascular and renal diseases. Although anti-hypertensive medications are often effective in the treatment of hypertension, non-pharmacological therapies are recognized as important first-line or adjunctive treatments for blood pressure management. A variety of relaxation and stress management techniques have been tested for their potential contributions to blood pressure control through stress reduction. Among these interventions, meditation training has shown the greatest promise as an adjunctive behavioral treatment for lowering blood pressure. This project investigates the effectiveness of a meditation-training program for the reduction of blood pressure. The 3-year study is a randomized, controlled clinical trial involving 120 adult men and women with hypertension or high-normal blood pressure recruited from the community. After extended screening and baseline testing, participants will be assigned at random to receive the experimental meditation training program (N= 60), to receive a progressive muscle relaxation training program that serves as a placebo control (N = 30), or to continue with usual care (N= 30). Post-treatment testing will be conducted 1, 2, and 3 months after training begins. Treatment outcome will be assessed by changes in laboratory-based and 24-hour ambulatory measures of blood pressure from baseline to follow-up. In addition, the study will test whether stress-reduction is a plausible mechanism that can account for clinical outcomes, using measurements of treatment-related changes in neuroendocrine and subjective measures of stress. Finally, the study will investigate the characteristics of those who respond best to this treatment and determine whether those individuals who begin training with higher levels of stress and anxiety show greater improvements in blood pressure and measures of stress than those who begin with lower levels. Meditation training may be a cost-effective non-pharmacological treatment for the management of high blood pressure. The results of this trial will advance our understanding of the potential benefits of this behavioral intervention, the mechanisms through which it works, and the kind of person who will benefit most from it.

描述（由申请人提供）：高血压是主要的公众 影响美国近25％的成年人的健康问题 并通过 心血管和肾脏疾病。虽然抗高血压药是 通常在治疗高血压，非药物疗法方面有效 被认为是血液的重要一线或辅助治疗 压力管理。多种放松和压力管理技术 已经对其对血压控制的潜在贡献进行了测试 通过减轻压力。在这些干预措施中，冥想培训有 作为降低的辅助行为待遇，表现出最大的希望 血压。 该项目调查了冥想训练计划的有效性 用于降低血压。这项为期三年的研究是一个随机的 对照临床试验涉及120名成年男女高血压 或从社区招募的高正常血压。延长后 筛查和基线测试，将随机分配参与者 接受实验冥想训练计划（n = 60），以接收 作为安慰剂控制的渐进肌肉放松训练计划 （n = 30），或继续进行常规护理（n = 30）。治疗后测试将 训练开始后1、2和3个月进行。治疗结果会 通过基于实验室和24小时的门诊措施的变化来评估 从基线到随访的血压。此外，该研究将测试 减少压力是否是可以解释临床的合理机制 结果，使用与治疗相关的神经内分泌和治疗相关变化的测量 压力的主观度量。最后，研究将研究 那些对这种治疗方法做出最佳反应并确定的人的特征 那些开始以更高水平的压力和 焦虑表明血压和压力度量的改善比 那些以较低水平开头的人。 冥想训练可能是一种具有成本效益的非药物治疗 高血压的管理。该试验的结果将进步 我们对这种行为干预的潜在好处的理解， 它运作的机制以及将受益的人 大多数。