Improving Physical Activity and Fitness in Comorbidity

改善合并症的体力活动和健康

• 批准号: 6794013
• 负责人: ELIZABETH Ann SCHLENK
• 金额: $ 8.15万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794013
• 关键词: aerobic exercise; behavioral /social science research tag; breath tests; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular function; clinical research; comorbidity; glucose tolerance; human middle age (35-64); human old age (65+); human subject; knee; longitudinal human study; muscle strength; osteoarthritis; personal log /diary; physical fitness; physical therapy; statistics /biometry; telecommunications; therapy compliance; videotape /videodisc

DESCRIPTION (provided by applicant): The long-term goal of the candidate in this KO1 application is to launch a focused and sustained program of research in the barriers that inhibit and the potential strategies that facilitate physical activity and improved cardiorespiratory fitness among persons with cardiovascular (CV) risk. Despite the health benefits of physical activity, 51 percent of persons age 65 to 74 engage in no physical activity. A primary national health goal, identified in Healthy People 2010, is to increase the proportion of adults who engage regularly, preferably daily, in moderate physical activity for at least 30 minutes. In no population is this more important than in those with CV risk. A prevalent and significant CV risk factor is impaired fasting glucose (IFG). About 13.6 million Americans have IFG. A significant barrier to physical activity in this population is imposed by osteoarthritis (OA) of the knee, a condition found in at least 2.5 million persons with IFG. Only 15 percent of persons with OA participate in regular physical activity. The underlying pathology can be managed through a program of quadriceps strengthening and graduated walking, yet only half engage in these exercises. A first step in the development of a regular physical activity program of potential benefit to CV disease prevention among older adults may be to address the barrier of OA of the knee. No work has been done in this area. Using a randomized controlled design, we propose to determine whether a self-efficacy based intervention designed to promote adherence to quadriceps strengthening and subsequent walking results in adherence to knee exercise, adoption (6 months) and maintenance (12 months) of regular physical activity (walking), and improvements in cardiorespiratory fitness in a convenience sample of 48 persons age 50 or older with IFG and OA of the knee. Subjects will be randomized to the 24-week intervention or to usual care and assessed at the baseline period, end of the intervention period, and 6 months after the intervention period ends using self-report and electronic pedometer measures of exercise, maximal graded cycle ergometer exercise tests, and an exercise self-efficacy measure. The intervention will incorporate strategies based on self-efficacy theory and consist of six individualized weekly sessions with a physical therapist followed by nine biweekly telephone delivered counseling sessions with a nurse. Data will be analyzed using repeated measures regression techniques.

描述（由申请人提供）：本 KO1 申请中候选人的长期目标是针对心血管疾病患者的抑制障碍和促进体力活动和改善心肺健康的潜在策略启动一项有重点和持续的研究计划（CV）风险。尽管体力活动对健康有益，但 65 岁至 74 岁之间的人中有 51% 不参加体力活动。 《2010 年健康人口》中确定的一项主要国家健康目标是增加定期（最好是每天）进行至少 30 分钟适度体力活动的成年人比例。对于有心血管风险的人群来说，这一点最为重要。空腹血糖受损 (IFG) 是一个普遍且重要的心血管危险因素。大约有 1360 万美国人患有 IFG。膝骨关节炎 (OA) 是该人群身体活动的一个重大障碍，至少有 250 万 IFG 患者患有这种疾病。只有 15% 的 OA 患者定期参加体育活动。潜在的病理可以通过股四头肌强化和渐进步行计划来控制，但只有一半人参与这些练习。制定对老年人预防心血管疾病有潜在益处的定期体育活动计划的第一步可能是解决膝关节骨关节炎的障碍。该领域尚未开展任何工作。使用随机对照设计，我们建议确定旨在促进股四头肌强化和随后步行的坚持的基于自我效能的干预措施是否会导致坚持膝盖锻炼、采用（6个月）和维持（12个月）定期体育活动（步行），以及 48 名 50 岁或以上患有 IFG 和膝关节 OA 的方便样本的心肺健康的改​​善。受试者将被随机分配接受 24 周干预或常规护理，并在基线期、干预期结束时以及干预期结束后 6 个月使用自我报告和电子计步器测量运动、最大分级自行车测力计进行评估运动测试和运动自我效能感测量。该干预措施将结合基于自我效能理论的策略，包括每周与物理治疗师进行六次个性化会议，随后与护士进行九次每两周一次的电话咨询会议。将使用重复测量回归技术来分析数据。