Applying Exercise Intervention to Drug Treatment

将运动干预应用于药物治疗

• 批准号: 6420700
• 负责人: RICHARD A BROWN
• 金额: $ 26.99万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420700
• 关键词: adult human (21+); aerobic exercise; behavior therapy; behavioral /social science research tag; breath tests; cardiovascular function; clinical trials; depression; drug controls; goal oriented behavior; health behavior; human subject; human therapy evaluation; interview; longitudinal human study; method development; motivation; outcomes research; patient oriented research; psychological reinforcement; questionnaires; statistics /biometry; substance abuse related behavior; substance abuse related disorder; therapy compliance; urinalysis

DESCRIPTION: (provided by applicant) Intervention to increase exercise in drug dependent patients represents a potentially useful yet unexplored strategy for preventing relapse. There are currently no established exercise interventions for use with this population. The long-term objectives of this research program are to improve treatment options for drug dependent patients by developing and establishing the efficacy of a supervised aerobic exercise intervention and to advance knowledge of the relationship between physical activity and substance use outcomes. In the present application, we propose to develop a supervised aerobic exercise (SAE) intervention for drug dependent patients and to conduct a preliminary, randomized clinical trial, examining its efficacy in comparison to a brief advice (BA) exercise intervention. In the first phase of this project (Year 1), we will develop and pilot the SAE intervention with 20 patients completing an intensive day and evening alcohol and drug treatment program. We will also develop a behavioral component to promote exercise adherence, including clinician and patient manuals. In the second phase (Years 2 & 3) we will conduct a preliminary, randomized trial with 50 sedentary drug dependent patients to examine the efficacy of the SAE intervention relative to the BA comparison condition over a six-month follow-up period. We expect that, relative to the BA condition, participants randomized to the SAE condition will demonstrate better substance use outcomes as well as improved mood, depressive symptoms, and cardiorespiratory fitness. If the efficacy of this intervention can be established in this trial and in subsequent clinical trials, drug dependent patients will be provided with a valuable adjunct or alternative to traditional substance abuse treatment.

描述：（由申请人提供） 增加药物依赖患者运动的干预措施代表了 潜在有用但尚未探索的预防复发的策略。有 目前尚无针对该人群的既定运动干预措施。 该研究计划的长期目标是改善治疗 通过开发和建立疗效为药物依赖患者提供选择 监督有氧运动干预并提高对有氧运动的了解 体力活动与物质使用结果之间的关系。 在本申请中，我们建议开发一种监督有氧运动 (SAE) 对药物依赖患者进行干预并进行初步、 随机临床试验，与简短的临床试验相比检查其功效 建议（BA）运动干预。在该项目的第一阶段（第一年）， 我们将开发并试点 SAE 干预措施，让 20 名患者完成一项研究 白天和晚上强化酒精和药物治疗计划。我们也会 制定行为组成部分以促进锻炼坚持，包括 临床医生和患者手册。在第二阶段（第 2 年和第 3 年），我们将 对 50 名久坐的药物依赖者进行初步随机试验 患者检查 SAE 干预相对于 BA 的功效 六个月随访期间的比较情况。 我们预计，相对于 BA 条件，参与者随机分配到 SAE 状况将表现出更好的物质使用结果以及 改善情绪、抑郁症状和心肺健康。如果 该干预措施的有效性可以在本试验中确定 随后的临床试验中，将为药物依赖患者提供 传统药物滥用治疗的有价值的辅助或替代方案。