Visceral Fat and Autonomic-Circulatory Control in Humans

人类内脏脂肪和自主循环控制

• 批准号: 6726830
• 负责人: KEVIN P DAVY
• 金额: $ 9.92万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6726830
• 关键词: adipose tissue; baroreflex; blood flow measurement; body composition; cardiovascular function; clinical research; genetic susceptibility; human subject; obesity; vagus nerve; vascular smooth muscle nervous control

DESCRIPTION (provided by applicant) This K02 Award proposal requests salary support to protect the applicants time to focus on the proposed studies and associated career development plan. The principal investigator's long-term career goal is to develop a nationally recognized, extramurally funded laboratory focused on determining the mechanisms and consequences of autonomic-circulatory dysfunction in obesity, particularly in those with elevated abdominal visceral fat. Toward this end, the aims of the present proposal are to determine the influence of elevated abdominal visceral fat on: 1) cardiac vagal modulation of heart rate and muscle sympathetic nerve activity (MSNA) in humans; 2) arterial baroreflex stimulation cardiac vagal outflow and inhibition of MSNA, and 3) vascular responsiveness to sympathetic stimulation in humans. The applicant also proposes to obtain preliminary data regarding the influence of DNA sequence variations in specific candidate genes alone and in combination with elevated abdominal visceral fat on autonomic-circulatory phenotypes. The research proposed in this K02 Award will allow the candidate to expand the scope of his current R01 award and enhance his research skills in a number -of areas related to obesity and autonomic-circulatory control in humans namely, 1) to expand the use and application of neurophysiological and vascular imaging techniques; 2) to obtain additional training in the assessment of body composition and regional body fat distribution; and 3) to obtain experience and skills in physiological genomics to study the influence of DNA sequence variations in specific candidate genes on autonomic-circulatory phenotypes alone and in combination with elevated abdominal visceral fat. The protected time and enhancement of research skills provided by this award will equip the candidate to conduct biomedical research well into the future. The results of this investigation will provide new physiologically and clinically important information regarding the contribution of visceral fat and genetics alone and in combination to human variation in autonomic-circulatory control. This information is crucial considering the growing recognition that autonomic dysfunction may be causal factor in a number of CVD states (e.g., essential hypertension) all of which become more prevalent with increasing levels of total body and abdominal visceral fat, particularly in susceptible individuals. (End of Abstract)

描述（由申请人提供） 此 K02 奖项提案要求工资支持以保护申请人的时间 专注于拟议的研究和相关的职业发展计划。 这 首席研究员的长期职业目标是在全国范围内发展 公认的、校外资助的实验室，专注于确定 肥胖症自主循环功能障碍的机制和后果， 尤其是那些腹部内脏脂肪升高的人。 为了这个目的， 本提案的目的是确定升高的影响 腹部内脏脂肪对：1）心脏迷走神经对心率的调节和 人类肌肉交感神经活动（MSNA）； 2) 动脉压力反射 刺激心脏迷走神经流出和抑制 MSNA，以及 3) 血管 人类对交感神经刺激的反应。 申请人还 提议获得有关 DNA 序列影响的初步数据 单独或与升高结合的特定候选基因的变异 腹部内脏脂肪对自主循环表型的影响。 研究 K02 奖中提出的建议将使候选人能够扩大其研究范围 目前的 R01 奖项并增强他在多个领域的研究技能 与人类肥胖和自主循环控制有关，即，1) 扩大神经生理学和血管成像的用途和应用 技术； 2）获得身体评估方面的额外培训 身体脂肪的成分和区域分布； 3）获得经验 和生理基因组学技能来研究 DNA 序列的影响 特定候选基因对自主循环表型的变异 单独使用或与腹部内脏脂肪升高结合使用。 受保护的 该奖项提供的时间和研究技能的提高将使 未来进行生物医学研究的候选人。 结果 这项研究将提供新的生理学和临床上重要的信息 有关内脏脂肪和遗传因素的单独贡献的信息，以及 与人类自主循环控制的差异相结合。 这 考虑到人们越来越认识到自主性 功能障碍可能是许多 CVD 状态的致病因素（例如，必需的 高血压），所有这些随着高血压水平的增加而变得更加普遍 全身和腹部内脏脂肪，特别是易感人群 个人。 （摘要完）