Vascular Consequences of Ultra-Processed Foods in Middle-Aged Adults

超加工食品对中年人血管的影响

基本信息

批准号：
10683369
负责人：
KEVIN P DAVY
金额：
$ 24.53万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10683369
关键词：
Address Adult Age Aging American diet Behavior Bile Acids Blood Vessels Body Weight Changes Carbohydrates Cardiovascular Diseases Chemicals Clinical Coronary Arteriosclerosis Cross-Over Trials Diagnostic Diet Dietary Factors Dietary Fiber Dietary Intervention Disease Endotoxins Fatty acid glycerol esters Food Future Health Heart Individual Industrialization Inflammation Inflammatory Intake Intervention Studies Intestinal permeability Lead Link Measurement Mediating Micronutrients Observational Study Outcome Study Participant Physiological Probiotics Process Production Proteins Public Health Randomized Risk Risk Factors Role Serum Sodium Vascular Diseases Volatile Fatty Acids Vulnerable Populations age related arterial stiffness cardiovascular disorder risk cardiovascular risk factor cytokine design dietary dietary guidelines experience food consumption gut inflammation gut microbiota improved innovation insight microbial microbiota middle age novel nutrition polyunsaturated fat saturated fat success sugar translational potential treatment duration

项目摘要

Project Summary Age is the primary risk factor for cardiovascular disease (CVD) and age-related vascular dysfunction is considered the key process linking the two. Middle age is particularly vulnerable period when risk factors exceed diagnostic thresholds and clinical expression of CVD first becomes evident. Ultra-processed foods (UPF) comprise almost 60% of total energy in the standard American diet (SAD). The results of observational studies suggest that UPF consumption increases CVD risk, independent of overall diet quality (i.e., saturated fat, sodium, sugar, and dietary fiber intake). The “industrialized microbiota” may link diet, particularly UPF, to increased inflammation and CVD in middle-aged adults. High intake of UPF increases the likelihood of an excess heart age >10years and doubles the risk of subclinical coronary atherosclerosis in middle-aged adults. However, the impact of reducing UPF consumption on vascular function in middle-aged adults is unknown. The overall objective of this R21 proposal is to establish proof-of-concept for an improvement in vascular function following reductions in UPF consumption in middle-aged adults, in order to conduct a larger, more comprehensive and mechanistic trial in the future. To this end, following a 2-week eucaloric lead-in diet (SAD with 60% UPF), 34 healthy middle-aged adults (45-64 yrs) will complete a 4-week randomized crossover trial of both a SAD and an un/minimally processed foods (0% UPF). A 2-week washout period (same SAD lead-in diet) will separate the treatments. Participants will be fed a eucaloric diet (50% carbohydrate, 35% fat, 15% protein) matched for dietary fiber, added sugars, saturated fat, mono- and poly-unsaturated fat, sodium, pre- and probiotics, micronutrients, and overall diet quality, for the duration of the study to avoid potential confounds of weight change and other dietary factors which may influence study outcomes. Commercial additive content of study diets will be quantified, and study diet composition will be verified by chemical analysis. Measurements of flow- mediated dilation, arterial stiffness, gut microbiota composition/function, fecal short chain fatty acids (SCFA), intestinal inflammation, intestinal permeability, serum endotoxin, and inflammatory cytokines will be made before and following each 4-week treatment period. This innovative study will be conducted by an established investigative team with extensive experience and a strong record of success performing well-controlled dietary intervention studies targeting aging and CVD risk.

项目概要年龄是心血管疾病（CVD）的主要危险因素，年龄相关的血管功能障碍被认为连接两者的关键过程是中年时期，此时风险因素超出了诊断范围。 CVD 的阈值和临床表现首先变得明显，超加工食品 (UPF) 占近 60%。标准美国饮食 (SAD) 中的总能量观察研究的结果表明 UPF。摄入量会增加 CVD 风险，与整体饮食质量（即饱和脂肪、钠、糖和饮食）无关。 “工业化微生物群”可能将饮食（尤其是 UPF）与炎症和 CVD 的增加联系起来。中年成年人摄入大量 UPF 会增加心脏年龄超过 10 岁的可能性，并使心脏年龄增加一倍。然而，减少 UPF 摄入量的影响。 R21 提案的总体目标是建立。中年人减少 UPF 摄入量后血管功能得到改善的概念验证成人，以便今后进行更大规模、更全面、更机械化的试验。为期 2 周的真热量摄入饮食（SAD，60% UPF），34 名健康中年人（45-64 岁）将完成为期 4 周的饮食 SAD 和未/最低加工食品（0% UPF）的随机交叉试验 2 周的清除期。（相同的 SAD 导入饮食）将分开治疗。参与者将接受无热量饮食（50% 碳水化合物，35%）。脂肪，15% 蛋白质）与膳食纤维、添加糖、饱和脂肪、单不饱和脂肪和多不饱和脂肪、钠、预以及益生菌、微量营养素和整体饮食质量，在研究期间避免潜在的混淆体重变化和其他可能影响研究结果的饮食因素。饮食将被量化，并且研究饮食成分将通过化学分析测量来验证。介导的扩张、动脉僵硬度、肠道微生物群组成/功能、粪便短链脂肪酸 (SCFA)、肠道前后进行炎症、肠道通透性、血清内毒素、炎性细胞因子的检测这项创新研究将由一个已建立的调查小组进行，每 4 周为一个治疗周期。丰富的经验和良好的成功记录，针对目标进行良好控制的饮食干预研究衰老和心血管疾病风险。