Vascular Consequences of Ultra-Processed Foods in Middle-Aged Adults

超加工食品对中年人血管的影响

• 批准号: 10683369
• 负责人: KEVIN P DAVY
• 金额: $ 24.53万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683369
• 关键词: Address; Adult; Age; Aging; American diet; Behavior; Bile Acids; Blood Vessels; Body Weight Changes; Carbohydrates; Cardiovascular Diseases; Chemicals; Clinical; Coronary Arteriosclerosis; Cross-Over Trials; Diagnostic; Diet; Dietary Factors; Dietary Fiber; Dietary Intervention; Disease; Endotoxins; Fatty acid glycerol esters; Food; Future; Health; Heart; Individual; Industrialization; Inflammation; Inflammatory; Intake; Intervention Studies; Intestinal permeability; Lead; Link; Measurement; Mediating; Micronutrients; Observational Study; Outcome Study; Participant; Physiological; Probiotics; Process; Production; Proteins; Public Health; Randomized; Risk; Risk Factors; Role; Serum; Sodium; Vascular Diseases; Volatile Fatty Acids; Vulnerable Populations; age related; arterial stiffness; cardiovascular disorder risk; cardiovascular risk factor; cytokine; design; dietary; dietary guidelines; experience; food consumption; gut inflammation; gut microbiota; improved; innovation; insight; microbial; microbiota; middle age; novel; nutrition; polyunsaturated fat; saturated fat; success; sugar; translational potential; treatment duration

Project Summary Age is the primary risk factor for cardiovascular disease (CVD) and age-related vascular dysfunction is considered the key process linking the two. Middle age is particularly vulnerable period when risk factors exceed diagnostic thresholds and clinical expression of CVD first becomes evident. Ultra-processed foods (UPF) comprise almost 60% of total energy in the standard American diet (SAD). The results of observational studies suggest that UPF consumption increases CVD risk, independent of overall diet quality (i.e., saturated fat, sodium, sugar, and dietary fiber intake). The “industrialized microbiota” may link diet, particularly UPF, to increased inflammation and CVD in middle-aged adults. High intake of UPF increases the likelihood of an excess heart age >10years and doubles the risk of subclinical coronary atherosclerosis in middle-aged adults. However, the impact of reducing UPF consumption on vascular function in middle-aged adults is unknown. The overall objective of this R21 proposal is to establish proof-of-concept for an improvement in vascular function following reductions in UPF consumption in middle-aged adults, in order to conduct a larger, more comprehensive and mechanistic trial in the future. To this end, following a 2-week eucaloric lead-in diet (SAD with 60% UPF), 34 healthy middle-aged adults (45-64 yrs) will complete a 4-week randomized crossover trial of both a SAD and an un/minimally processed foods (0% UPF). A 2-week washout period (same SAD lead-in diet) will separate the treatments. Participants will be fed a eucaloric diet (50% carbohydrate, 35% fat, 15% protein) matched for dietary fiber, added sugars, saturated fat, mono- and poly-unsaturated fat, sodium, pre- and probiotics, micronutrients, and overall diet quality, for the duration of the study to avoid potential confounds of weight change and other dietary factors which may influence study outcomes. Commercial additive content of study diets will be quantified, and study diet composition will be verified by chemical analysis. Measurements of flow- mediated dilation, arterial stiffness, gut microbiota composition/function, fecal short chain fatty acids (SCFA), intestinal inflammation, intestinal permeability, serum endotoxin, and inflammatory cytokines will be made before and following each 4-week treatment period. This innovative study will be conducted by an established investigative team with extensive experience and a strong record of success performing well-controlled dietary intervention studies targeting aging and CVD risk.

项目摘要 年龄是心血管疾病（CVD）的主要危险因素，并且与年龄有关的血管功能障碍被认为是 链接两者的关键过程。当风险因素超过诊断时，中年特别脆弱的时期 CVD的阈值和临床表达首先成为证据。超级加工食品（UPF）占几乎60％ 美国标准饮食中的总能量（SAD）。观察性研究的结果表明UPF 消费增加了CVD风险，与整体饮食质量无关（即饱和脂肪，钠，糖和饮食 纤维摄入）。 “工业化的微生物群”可能会将饮食，尤其是UPF与注射量增加和CVD联系起来 中年成年人。 UPF的高摄入量增加了超过心脏年龄> 10岁的可能性，并使 中年成年人中亚临床冠状动脉粥样硬化的风险。但是，减少UPF消费的影响 中年成年人的血管功能尚不清楚。该R21提案的总体目标是建立 减少中年UPF消耗后，概念概念证明是提高血管功能的概念 成年人将来要进行更大，更全面和机械的试验。为此，遵循 2周的欧卡罗式铅饮食（与60％UPF SAD），34位健康的中年成年人（45 - 64年）将完成为期4周 对SAD和未加工食品的随机分频试验（0％UPF）。 2周的冲洗期 （相同的悲伤饮食饮食）将分开治疗方法。参与者将获得欧加利亚饮食（50％碳水合物，35％ 脂肪，15％蛋白质）匹配饮食纤维，添加糖，饱和脂肪，一单脂肪和多饱和脂肪，钠，钠，前脂肪 在研究期间，益生菌，微量营养素和整体饮食质量，以避免潜在的混杂 体重变化和其他可能影响研究结果的饮食因素。商业添加剂的学习内容 饮食将进行量化，研究饮食组成将通过化学分析验证。流量的测量 介导的词典，动脉刚度，肠道菌群组成/功能，粪便短链脂肪酸（SCFA），肠道 将在炎症，肠道通透性，血清内毒素和炎症细胞因子之前和关注之前进行 每个4周的治疗期。这项创新研究将由一个既定的调查团队进行 丰富的经验和成功执行良好控制饮食干预研究的成功记录 衰老和CVD风险。