Phase 1 - Integrated Cancer Data Management System

第一阶段 - 综合癌症数据管理系统

• 批准号: 6790787
• 负责人: Antony Chiang
• 金额: $ 10万
• 依托单位: ALTRUE.COM, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-19 至 2005-10-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6790787
• 关键词: Internet; automated data processing; cancer information system; cancer registry /resource; computer graphics /printing; computer human interaction; computer program /software; computer system design /evaluation; data management; library; molecular biology information system

DESCRIPTION (provided by applicant): This proposal intends to test the use of open source software technologies to fulfill the critical need of academic and small- to medium sized private research laboratories for a robust yet cost effective solution to their ever-growing data management, distribution, integration and analysis problems. In collaboration with researchers at the University of California, San Francisco (UCSF) Comprehensive Cancer Center, the PI would analyze workflows, develop a prototype specification for an Integrated Cancer Data Management System (ICDMS), design and develop the prototype, and have collaborating users test the prototype to determine its efficacy at achieving program objectives. A successful ICDMS would address the growing need of researchers to integrate distributed cross-disciplinary data sources into coherent knowledge bases for biomedical research. Researchers' prevalent practice of manually referencing related information in federated data sources is error-prone, time consuming and tedious, and must be repeatedly updated. In addition, researchers' source data comes from multiple runs on multiple instruments performed by multiple people. The ICDMS would address these issues with a graphical web-based workspace that allows researchers to organize and manipulate data from different sources, apply visualization and other analytics, query analytical results across distributed data sources for related valuable information, and easily access and share that workspace. Researchers at UCSF will test the ICDMS in a real-life environment. The PI will prove viability of the ICDMS by focusing on genomic and cytometric data utilized in breast cancer research in a representative active research program that generates high volume data sets and requires related queries across federated databases for effective research results. Establishing the viability and subsequent use of an online system such as the ICDMS has profound implications by creating enabling technology with the following impacts: 1. Increasing the progress rate of a research study or patient analysis, by allowing researchers to more effectively focus their efforts on the most promising data sets; 2. Increasing the progress rate by allowing researchers to save time and increase accuracy by automatically relating the significant data sets with other large data sources; 3. Increasing the continuity of research efforts as personnel in laboratories change; 4. Increasing the ability of researchers at different sites or in different disciplines to collaborate.

描述（由申请人提供）： 该建议旨在测试开源软件技术的使用，以满足学术和中小型私人研究实验室的关键需求，以实现强大而具有成本效益的解决方案，以解决其不断增长的数据管理，分发，集成和分析问题。与加利福尼亚大学旧金山大学（UCSF）综合癌症中心的研究人员合作，PI将分析工作流程，为综合癌症数据管理系统（ICDMS）开发原型规范，设计和开发原型，并使其协作用户测试其原型以确定其在成熟的计划目标上的效率。 成功的ICDM将解决研究人员日益增长的需求，将分布式跨学科数据源整合到生物医学研究的连贯知识库中。研究人员在联合数据源中手动参考相关信息的普遍做法是错误的，耗时且乏味的，必须反复更新。此外，研究人员的源数据来自多个由多个人执行的工具的多次运行。 ICDM将通过基于图形的Web工作空间解决这些问题，该工作空间使研究人员可以组织和操纵来自不同来源的数据，应用可视化和其他分析，在分布式数据源之间查询分析结果，以获取相关的有价值信息，并轻松访问和共享工作区。 UCSF的研究人员将在现实生活环境中测试ICDM。 PI将通过在代表性的主动研究计划中专注于乳腺癌研究中使用的基因组和细胞学数据来证明ICDM的生存能力，该计划生成大量数据集，并需要在联邦数据库中进行相关查询以进行有效的研究结果。通过创建具有以下影响的启用技术来建立在线系统（例如ICDMS）的生存能力和后续使用具有深远的影响： 1。提高研究研究或患者分析的进度率，使研究人员能够更有效地将精力集中在最有希望的数据集上； 2。通过允许研究人员通过自动将重要数据集与其他大型数据源联系起来来节省时间并提高准确性来提高进度率； 3。随着实验室人员的变化，增加研究工作的连续性； 4。提高研究人员在不同站点或不同学科的协作能力。