Phase 2 SBIR - Research Data Management System

第 2 阶段 SBIR - 研究数据管理系统

• 批准号: 7036005
• 负责人: Antony Chiang
• 金额: $ 37.15万
• 依托单位: BIOTRUE, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-06 至 2005-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7036005
• 关键词: Internet; computer program /software; computer system design /evaluation; confocal scanning microscopy; data collection; data management; digital imaging; flow cytometry; online computer

DESCRIPTION (provided by applicant): Researchers must deal with increasingly vast quantities of data produced over multiple projects, by multiple instruments, and by multiple people. Current ad hoc methods of managing internal research data are prone to error and time consuming. The Phase I prototype Research Data Management System (RDMS) proved the viability of utilizing the Pl's commercially successful content management system (created with the open source web based database platform technology of Linux/PHP/MySQL/Java) to successfully develop a scalable, affordable, and commercially viable solution which will provide the ability to (a) easily collect data directly from laboratory instruments, (b) easily and automatically couple the data with annotation information that describes and explains it, (c) easily store, retrieve, share, and analyze the data and associated documents in a secure environment accessible via the Internet. Phase 1 results achieved each its Specific Aims and exceeded the expectations of the alpha testers at UCSF Cancer Center and Gladstone Institute. The Pl's goal for this Phase II proposal is to develop a scalable, commercially viable version of the RDMS to fulfill the needs of academic and small to medium commercial laboratories in a user-friendly and affordable manner. Phase II will scale the software to a broad range of instrumentation data types, a greater set of annotation and retrieval tools, and different biomedical research end points. Phase II will utilize the expertise of the Gladstone Institute Flow Cytometry Core and the UCSF Laboratory for Cell Analysis for specification design and testing. In addition, core labs at the Fox Chase Cancer Center, Carnegie-Mellon, and Lawrence Berkeley National Laboratory will participate in beta testing. Development of such an online system has profound implications by creating enabling technology with the following impact: 1) increase the progress rate of a research study or patient analysis, 2) Increase the continuity of research efforts as personnel in laboratories change, 3) Increase the ability to collaborate between researchers at different sites, 4) Increase the ability to verify or utilize past research study and patient analysis results, and 5) Increase the security of perhaps irreproducible data and analyses. PI has an extensive track record of successfully commercializing data management solutions for the public sector market.

描述（由申请人提供）：研究人员必须处理越来越多的数据，由多个项目，多个工具和多人处理。当前管理内部研究数据的临时方法容易出错。第一阶段原型研究数据管理系统（RDMS）证明了利用PL的商业成功内容管理系统（使用基于开源Web的开源Web数据库平台技术创建的可行性（使用Linux/php/php/mysql/java的数据库平台技术）成功地开发可扩展，负担得起的，可负担的和商业可用的解决方案，该解决方案可以轻松地提供（可轻松地）数据，该数据可以轻松地（A）（A）（A）（A）（A A）（A）（A A），A（a），a（a），b）（a a），b描述和解释它，（c）在可以通过Internet访问的安全环境中轻松存储，检索，共享和分析数据和相关文档。 第1阶段的结果达到了每个特定目标，并超过了UCSF癌症中心和Gladstone Institute的Alpha测试人员的预期。 PL的II阶段提案的目标是开发可扩展的，商业上可行的RDMS版本，以以用户友好且负担得起的方式满足学术和中小型商业实验室的需求。第二阶段将将软件扩展到广泛的仪器数据类型，更大的注释和检索工具以及不同的生物医学研究终点。第二阶段将利用Gladstone Institute流式细胞仪核心和UCSF实验室的专业知识进行细胞分析进行规范设计和测试。此外，Fox Chase Cancer Center，Carnegie-Mellon和Lawrence Berkeley国家实验室的核心实验室将参加Beta测试。通过创建启用技术的影响：1）提高研究或患者分析的进度率，2）随着实验室人员的变化，增加研究工作的连续性，3）增加研究人员在不同站点之间的协作的能力，4）增加了过去的研究和患者分析的能力，以及5）可以分析的能力和5），则可以提高研究和5）的能力，并增加了IRRER的能力。 PI在公共部门市场上成功将数据管理解决方案商业化的广泛记录。