Affecting the epidemiology of HIV in Uganda through older adolescents

通过老年青少年影响乌干达艾滋病毒的流行病学

基本信息

批准号：
9267536
负责人：
Michele L. Ybarra
金额：
$ 21.07万
依托单位：
CENTER FOR INNOVATIVE PUBLIC HEALTH RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-17 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9267536
关键词：
17 year old 19 year old AIDS prevention Adolescence Adolescent Affect Africa South of the Sahara Age Age-Years Behavior Control Groups Country Data Developing Countries Development Eligibility Determination Ensure Epidemic Epidemiology Feedback Focus Groups HIV HIV Infections HIV Seropositivity HIV risk Hand Health Services Accessibility Heterosexuals Human immunodeficiency virus test Intervention Length Measures Outcome Measure Participant Population Prevalence Prevention program Preventive Public Health Randomized Reaction Recruitment Activity Research Research Personnel Resources Risk Services Sexual Abstinence Technology Testing Text Translating Uganda Visit Voice Woman Youth adolescent HIV prevention arm base condoms control trial cost design experience healthy sexuality high risk improved interest male multidisciplinary online resource post intervention programs public health relevance research study retention rate scale up sex sexually active skills tool transmission process web site young woman

项目摘要

DESCRIPTION (provided by applicant): Heterosexual sex is the primary mode of HIV transmission in Uganda, which is likely why prevalence increases dramatically from middle to late adolescence as young people become sexually active. Indeed, the percent of women with HIV jumps from 1.6% among 15- to 17-year-olds to 5.1% among 18- to 19-year-olds, and increases further to 7.1% among 20- to 22-year-olds. For males, rates also rise from 1.8% to 2.3% as they age from 15-17 years to 20-22 years of age. Clearly, curbing the HIV epidemic in Uganda requires culturally salient and theoretically-driven HIV prevention programming that is easily accessible to adolescents as they age through this period of risk. Given the epidemiology of the HIV epidemic in Uganda, intervention during late adolescence (i.e., 18-22 years of age) is key. We propose to develop the first-of-its-kind comprehensive HIV prevention program for Ugandan adolescents, timed to arm them with the skills necessary to reduce their HIV risk precisely as they move through a high-risk period. Being text messaging-based will ensure that the program is low-cost and easily scalable. By harnessing Facebook and other online resources, this proposal will be one of the first to develop and test an intervention nationally in Sub-Saharan Africa. Specifically, we aim to: Specific Aim 1: Design a 6-week text messaging-based HIV prevention and healthy sexuality program for adolescents 18-22 years old. Older adolescents will be recruited as focus group participants (n = 40) to explore acceptability of proposed program components (e.g., program length) and identify vernacular and "voice" that can be integrated into program messages. Once a draft of the messaging has been written, we will recruit a Content Advisory Council (CAC; n = 15) that will provide reactions to the content, scope, style, and tone of the messages. After integrating feedback, a second CAC (n = 15) will be conducted to confirm the suggested improvements have been translated effectively. Specific Aim 2: Pilot test the intervention for feasibility and acceptability among 18- to 22-year-old Ugandans (n = 200). Participants will be randomly assigned to the intervention or inactive control group. Our main outcome measures will focus on feasibility (e.g., recruitment and retention rates) and acceptability (e.g., Text Buddy, message content). Participants will be recruited online, mainly through Facebook. Specific Aim 3: Obtain preliminary data needed for a larger-scale controlled trial services study to examine program efficacy.

描述（由申请人提供）：异性性行为是乌干达艾滋病毒传播的主要方式，这可能就是为什么随着年轻人性行为活跃，艾滋病毒感染率从青春期中后期急剧增加的原因。事实上，女性感染艾滋病毒的比例从 1.6% 跃升。 15 至 17 岁人群中，18 至 19 岁人群中这一比例上升至 5.1%，20 至 19 岁人群中这一比例进一步上升至 7.1%。对于 22 岁的男性，随着年龄从 15-17 岁上升到 20-22 岁，感染率也从 1.8% 上升到 2.3%。鉴于乌干达艾滋病毒流行的流行病学，青春期后期（即 18-22 岁）的青少年很容易获得预防规划。我们建议为乌干达青少年制定首个全面的艾滋病毒预防计划，适时为他们提供必要的技能，以在他们度过高危期时降低他们的艾滋病毒风险。基于短信的计划将确保该计划成本低廉且易于扩展，通过利用 Facebook 和其他在线资源，该提案将是第一个在全国范围内开发和测试干预措施的提案。具体来说，我们的目标是：具体目标 1：为 18-22 岁的青少年设计为期 6 周的基于短信的艾滋病毒预防和健康性计划（n =）。 40) 探索拟议节目组成部分（例如节目长度）的可接受性，并确定可以融入节目信息的白话和“声音”。一旦编写了信息草案，我们将招募一个内容咨询委员会。（CAC；n = 15）将对消息的内容、范围、风格和语气做出反应。在整合反馈后，将进行第二次 CAC（n = 15）以确认建议的改进已得到有效落实。具体目标 2：在 18 至 22 岁的乌干达人（n = 200）中试点测试干预措施的可行性和可接受性，我们的主要结果指标将集中于参与者。可行性（例如，招募和保留率）和可接受性（例如，短信好友、消息内容）。具体目标 3：获取更大规模对照试验服务研究所需的初步数据，以检查项目。功效。